复杂性先天性心脏病（英文）

Eur Radiol DOI 10.1007/s00330-010-1822-7 PEDIATRIC Zhaoping Cheng Ximing Wang Yanhua Duan Lebin Wu Dawei Wu Baoting Chao Cheng Liu Zhuodong Xu Hongxin Li Fei Liang Jian Xu Jiuhong Chen Received: 28 December 2009 Revised: 15 March 2010 Accepted: 12 April 2010 # European Society of Radiology 2010 Low-dose prospective ECG-triggering dual-source CT angiography in infants and children with complex congenital heart disease: first experience Abstract Objective: To explore the clinical value of low-dose prospec- tive ECG-triggering dual-source CT (DSCT) angiography in infants and children with complex congenital heart disease (CHD) compared with transthoracic echocardiography (TTE). Methods: Thirty-five patients (mean age: 16months, range: 2months to 6years; male 15; mean weight: 12kg) underwent low-dose prospec- tive ECG-triggering DSCT angiogra- phy and TTE. Surgeries were performed in 29 patients, and con- ventional cardiac angiography (CCA) was performed in 8 patients. The accuracy was calculated based on the surgical and/or CCA findings. The overall imaging quality was evaluated on a five-point scale. Results: A total of 146 separate cardiovascular deformities were confirmed. DSCT missed three atrial septal defects and a patent ductus arteriosus. The accuracy of DSCT angiography and TTE was 97.3% (142/146) and 92.5% (135/146), respectively. Overall test parameters for DSCT angiography and TTE were similar (sensitivity, 97.3% vs 92.5%; specificity, 99.8% vs 99.8%). The average subjective image quality score was 4.3±0.7. The mean effective dose was 0.38±0.09mSv. Conclusions: Prospective ECG- triggering DSCT angiography with a very low effective radiation dose allows the accurate diagnosis of anomalies in infants and children with complex CHD compared with TTE. It has great promise to become a commonly used second-line technique for complex CHD. Keywords Congenital heart disease . Prospective ECG-triggering . Dual-source CTangiography . Transthoracic echocardiography . Radiation exposure Introduction Conventional cardiac angiography (CCA) is the recognised gold standard method for assessment of complex congen- ital heart disease (CHD) in infants and children, but it is an invasive procedure with a potential procedure-related mortality of around 1% [1] and has the potential to impart high radiation doses [2]. Because of the risk, several non- invasive examination methods have been proposed as the major techniques for investigating complex CHD in children with the aim of decreasing the use of CCA. Although transthoracic echocardiography (TTE) is usually the initial choice because of the availability and the logistic simplicity, it may not be the perfect diagnostic tool because it is limited by the acoustic window, spatial resolution and the subjective interpretation of the operator [3]. Recently, multi-detector CT with improved spatial and temporal resolution has been used more frequently in children with CHD [4–8]. Non-ECG-gated imaging is usually used for the evaluation of extracardiac structural abnormalities [5, 9]. Retrospectively ECG-gated CT was performed when morphological evaluation of rapidly moving intracardiac or paracardiac structures, including the ascending aorta, cardiac valves and coronary artery, Z. Cheng :X. Wang ()) :Y. Duan : L. Wu :D. Wu :B. Chao :C. Liu : Z. Xu Shandong Medical Imaging Research Institute, Shandong University, No.324, Jingwu Road, Jinan, Shandong 250021, China e-mail: wxming369@163.com Tel.: +86-531-86760780 Fax: +86-531-85186707 H. Li : F. Liang Department of Cardiovascular Surgery, Shandong Provincial Hospital, Jinan, Shandong, China J. Xu : J. Chen CT Research Collaboration, Siemens. Ltd. China, Beijing, China was required [6, 10]. However, the use of a low pitch or overlapping spiral CT acquisition results in the relatively high radiation dose of a retrospective ECG-gated exami- nation [7, 8]. Although the combined use of dose-saving methods including a body-size-adaptive CT protocol, low tube voltage and tube current modulation [11, 12] can reduce the CT dose to 3–6 mSv for the patients with CHD [13], high radiation is still the major inherent limitation for retrospective ECG-gated CT. Recently, prospective ECG-triggering or the step-and- shoot (SAS) technique, has been proposed to decrease radiation exposure in cardiac CT [14]. With this technique, radiation is only administered at predefined time points of the cardiac cycle, which is likely to be associated with a substantial reduction of the radiation dose. Recent studies have found that low-dose prospec- tive ECG-triggering CT angiography is feasible in adults with mean heart rates below 70 bpm with a low effective dose of 1–4 mSv [15, 16]. The upper mean heart rates were not evaluated in terms of the feasibility of prospective ECG-triggering CT. With the combination of 83-ms temporal resolution of dual-source CT (DSCT), potential application in patients with higher heart rates has become possible [17]. To our knowledge, so far there have been no studies demonstrating the feasibility of prospective ECG-trigger- ing DSCT angiography in infants and children. The purpose of this study is to explore the clinical value of low-dose prospective ECG-triggering DSCT angiography in infants and children with complex CHD. Materials and methods Patients Our study was approved by the local ethics board; written informed consent was obtained from all patients (their parents). In our institute, CT angiography is part of the cardiovascular evaluation in patients with complex CHD according to the clinical indications. As no precise definition exists, “complex” CHD is defined as congenital heart disease with more than one separate cardiovascular anomaly by their transthoracic echocardiography findings in this study. We prospectively enrolled 45 patients with complex CHD between January and May 2009 in our institute. General exclusion criteria for contrast-enhanced CT included nephropathy (serum creatinine level >150 mmol/l) (n=1) and known hypersensitivity to iodine-containing contrast medium (n=1). Patients with non-sinus rhythm were excluded from the study (n=1). Patients who had undergone palliative or corrective surgeries were also excluded (n=7). A total of thirty-five patients (mean age: 16 months, range: 2 months to 6 years; male 15; mean weight: 12 kg; mean heart rate: 115 bmp, range: 90–142 bmp) with complex CHD could be included in this study. All patients underwent low-dose prospective ECG-triggering DSCT angiography and TTE. Palliative or corrective surgeries were performed in 29 patients, and CCAs were performed in 8 patients. Prospective ECG-triggering DSCT angiog- raphy was performed without complications in all patients. There was no extravasation of contrast material at the injection site. There was no systemic reaction to the contrast material. Prospective dual-source CT protocol All prospective ECG-triggering DSCT angiography examinations were performed using a DSCT (Somatom Definition, Siemens, Forchheim, Germany) during free- breathing. Sedation was achieved with peroral chloral hydrate and administered according to the patient’s body weight and clinical condition. The anatomical region covered by the CT data acquisition was from the thoracic inlet level to L1–2. The following acquisition parameters were used: 2× 32×0.6 mm detector collimation, a slice collimation of 2× 64×0.6 mm enabled by Z-Sharp technology and a gantry rotation time of 0.33 s. Body weight-based adjustments of tube voltage and tube current were performed: <5 kg, tube voltage 80 kV, tube current 40–59 mAs; 5–10 kg, tube voltage 80 kV, tube current 60–79 mAs; >10 kg, tube voltage 80 kV, tube current 80–120 mAs. Prospective ECG-triggering technology necessitated a cycle time of 1.25 s for one acquisition and the subsequent table feed. The data acquisition window was 380 ms with padding technique. The centre of the data acquisition window was set at 40% of the R-R interval. The duration of the CT data acquisition was 5.39–9.14 s. A dual-head power injector (Stellant; Medrad, Indianola, PA) was used. The saline flush technique was applied for all injections to reduce artefacts caused by undiluted intra- vascular contrast agent. The high concentration contrast material (Schering Ultravist, Iopromide, 350 mg I/ml, Berlin, Germany) was injected via peripheral veins in the elbow or back of the hand. We used 2 ml/kg of contrast medium plus the saline flush with half volume of the total contrast medium. The delay time was set to 25 s. The contrast volume was divided by 30 (the delay time + 5 s) to produce the flow rate for both contrast medium and saline chaser. For example, a 5-kg baby with peripheral access would be injected with 10 ml of iopromide 350 and 5 ml saline flush at 0.5 ml/s [(10+5)/30]. Image post-processing and analysis Dual-source CT images were reconstructed in a mono- segment mode by using a section thickness of 0.75 mm and a medium smooth-tissue convolution kernel (B26f). Images were reconstructed from 32% to 48% of the R-R interval in 2% increments, and the best reconstruction phase was used for evaluations. All images were trans- ferred to an external workstation (Multi Modality Work- place, Siemens, Forchheim, Germany ) for further analysis. In addition to the CT axial slices, multiple planar reformation (MPR), volume rendering (VR) and maximum intensity projection (MIP) were used to visualise cardiac abnormalities. The interpretation of prospective ECG-triggering DSCT angiography was performed without knowing the result of surgical, CCA or TTE findings. Two radiologists with more than 5 years’ experience in cardiac radiology semi- quantitatively assessed the overall image quality inde- pendently on a five-point scoring system [18] as follows: 5: excellent anatomical clarity; excellent image quality. 4: good anatomical clarity; all structures are clearly interpretable. 3: fair anatomical clarity; the anatomical relationships required clinically could be defined with confidence. 2: poor image quality or anatomical detail; incomplete demonstration of anatomical structures. 1: no useful information obtained. For any disagreement in data analysis between the two observers, consensus agreement was achieved. Examina- tions graded 3, 4 or 5 were considered sufficient for complete diagnosis. Transthoracic echocardiography Two-dimensional TTE with Doppler ultrasound was per- formed from the apical, parasternal, subxiphoid and supra- sternal approaches using a SONOS 7500 ultrasound system (Philips Medical Systems, Bothell, WA). All studies were performed by an echocardographic technician with more than 7 years’ experience and were saved digitally. All echocardiographic studies were analysed by a paediatric cardiologist with more than 10 years’ experience blinded to other studies’ results. Radiation dose estimations The parameters for imaging range, dose-length product and volume CT dose index were obtained from the protocol that summarised the relevant individual radiation exposure parameters of each CT angiography examination [19]. The effective dose delivered at CT cardiac angiography was derived from the dose-length product and conversion coef- Fig. 1 A 16-month-old boy with the diagnosis of pulmonary atresia with the fistula between the proximal RCA and MPA. Prospective ECG-triggering DSCT was performed at 80 kV and 80 mAs (effective dose, 0.43 mSv). (a) Multiplanar reformatted image and (b) volume-rendered image (anterior view) show the fistula (thick arrow) between the proximal RCA and MPA. (c) Thick-section oblique sagittal MIP image shows the ventricular septal defect (VSD) and overriding aorta. (d) Volume-rendered image (posterior view) shows two MAPCAs (slim arrows) arising from the DA. AA = ascending aorta, RCA = right coronary artery, MPA = main pulmonary artery, RPA = right pulmonary artery, RV = right ventricle, LV = left ventricle, MAPCA = main aortopulmonary collateral artery, DA = descending aorta ficients [20]. Infant-specific dose-length product conversion coefficients were given for a 16-cm phantom: a coefficient of 0.039 mSv/[mGy·cm] until 4 months of age, 0.026 mSv/ [mGy·cm] between 4 months and 1 year of age, and 0.018 mSv/[mGy·cm] between 1 year and 6 years of age [21]. Statistics The results of surgical or CCA findings were utilised as the reference standard. Test parameters (sensitivity, specificity, positive and negative predictive values) were calculated for separate cardiovascular anomalies, and the 95% CIs were calculated. Quantitative data were expressed as means ± standard deviations, and categorical data were given in proportions and percentages. Interobserver agreement in subjective image quality grading was assessed by using kappa statistics, and к-values of 0.61–0.80 corresponded to good agreement. The accuracy of DSCT angiography and TTE was compared by using the non-parametric chi-squared test. A p value<0.05 was considered to indicate a significant difference. Results The final diagnoses of the 35 patients were pulmonary artery atresia with ventricle septal defect (n=5, Fig. 1), tetralogy of Fallot (n=10, Figs. 2 and 3), double outlet right ventricle (n= 5), interrupted aortic arch (n=2), coarctation of the aorta (n= 3 Fig. 4), anomalous origin of one pulmonary artery (n=1), total anomalous pulmonary venous return (n=2), anomalous systemic venous return (n=1) and transposition of great arteries (n=6) by surgical and/or CCA findings as the reference standard. A total of 146 separate cardiovascular deformities were confirmed by surgical and/or CCA findings. The accuracy of low-dose prospective ECG-triggering DSCT angiogra- phy and TTE in diagnosing separate cardiovascular deformities was 97.3% (142/146) and 92.5% (135/146), respectively. DSCT was as accurate as TTE in revealing cardiovascular deformities (χ2=3.48, P<0.05). Details on separate cardiovascular deformities are given in Table 1. Out of the total 735 diagnoses made, 17(2.3%) differences between DSCT angiography and TTE were found. The overall deformity-based sensitivity, specificity, positive Fig. 2 An 8-month-old boy with tetralogy of Fallot. Prospective ECG-triggering DSCTwas performed at 80 kV and 60 mAs (effective dose, 0.29 mSv). (a) Ventricular septal defect (VSD) and overriding aorta on the reformatted images. (b) Thick- section oblique sagittal MIP image during systole shows critical stenosis of the right ventricular outflow tract (RVOT). RCA = right coronary artery, RV = right ventricle, LV = left ventricle, Ao = aorta, MPA = main pulmonary artery, LPA = right pulmonary artery Fig. 3 A 1-year-old boy with tetralogy of Fallot. Prospective ECG-triggering DSCT was performed at 80 kV and 70 mAs (effective dose, 0.38 mSv). (a) Thick-section oblique sagittal MIP image shows critical stenosis of the pulmonary valve (white arrow). (b) Oblique coronal multiplanar reformatted image shows patent ductus arteriosus (PDA) between aortic arch (Ar) and left pulmonary artery (LPA). Note stenosis of the proximal LPA (black arrow). RV = right ventricle, MPA = main pulmonary artery, RPA = right pulmonary artery predictive value and negative predictive value were 97.3%, 99.8%, 99.3% and 99.3%, respectively, by DSCT angiography, and 92.5%, 99.8%, 99.3% and 98.2%, respectively, by TTE (Table 2). In four patients, TTE missed all of the coronary artery anomalies. In one patient with tetralogy of Fallot (Fig. 5), the right coronary artery arose from the left coronary sinus of Valsalva, which distributed two larger branches crossing in front of the right ventricular outlet. In another patient with transposition of the great arteries (Fig. 6), both the right coronary artery and the left coronary artery arose from the non-coronary sinus of Valsalva with a common ostium. The left main coronary crossed between the main pulmonary artery and the left atrium. In the remaining two patients, one coronary-pulmonary fistula and one high-take off of the left coronary artery were missed by TTE. TTEmissed two major aortopulmonary collateral arteries, three distal pulmonary artery stenoses and one anomalous systemic venous return. Fig. 4 A 14-month-old girl with coarctation of the aorta. Prospective ECG-triggering DSCT was performed at 80 kV and 80 mAs (effective dose, 0.41 mSv). (a) Multiplanar reformatted image shows simultaneously the atrial septum defect (ASD) and muscular ventricular septal defect (VSD) accompanied by coarctation of the aorta. (b) Volume-rendered image (posterior view) demonstrates narrowing of the aortic isthmus (arrow). RA = right atrium, LA = left atrium, RV = right ventricle, LV = left ventricle, AA = ascending aorta, Ar = aortic arch, DA = descending aorta, LSA = left subclavian artery, RSA = right subclavian artery Table 1 Findings at prospective ECG-triggering dual-source CT (DSCT) angiography and transthoracic echocadiography (TTE) in refe- rence to surgical findings and/or conventional cardiac angiography (CCA; n=35) Cardiovascular deformities Surgeries and/or CCA DSCT findings TTE findings TP TN FP FN TP TN FP FN Atrial septal defect 16 13 18 1 3 16 19 0 0 Ventricular septal defect 28 28 7 0 0 28 7 0 0 Right ventricular outflow tract stenosis 8 8 27 0 0 8 27 0 0 Double outlet right ventricle 5 5 30 0 0 5 30 0 0 Atrioventricular discordance 1 1 34 0 0 1 34 0 0 Pulmonary valve stenosis 3 3 32 0 0 3 32 0 0 Pulmonary artery stenosis 15 15 20 0 0 12 20 0 3 Patent ductus arteriosus 10 9 25 0 1 10 25 0 0 Pulmonary artery atresia 5 5 30 0 0 5 30 0 0 Dilated pulmonary artery 6 6 29 0 0 6 29 0 0 Anomalous origin of pulmonary artery 1 1 34 0 0 1 34 0 0 Anomalous pulmonary venous return 2 2 33 0 0 2 33 0 0 Anomalous systemic venous return 1 1 34 0 0 0 34 0 1 Overriding aorta 16 16 19 0 0 16 19 0 0 Coarctation of the aorta 3 3 32 0 0 3 31 1 0 Interrupted aortic arch 2 2 33 0 0 1 33 0 1 Transposition of the great arteries 6 6 29 0 0 6 29 0 0 Major aortopulmonary collateral artery 5 5 30 0 0 3 30 0 2 Right aortic arch 5 5 30 0 0 5 30 0 0 Double superior vena cava 4 4 31 0 0 4 31 0 0 Coronary artery anomaly 4 4 31 0 0 0 31 0 4 Total 146 142 588 1 4 135 588 1 11 TP, true positive detection; TN, true negative detection; FP, false positive detection; FN, false negative detection TTE misdiagnosed one patient as having coarctation of the aorta; operative and DSCT findings confirmed the actual diagnosis of interrupted aortic arch. On the other hand, DSCT misdiagnosed one normal atrium as one atrial septal defect and missed three atrial septal defects and a very small patent ductus arteriosus. One patient without atrial septal defect was misdiagnosed because of the streak artefacts produced by high-attenuation contrast material at the right atrium. In other patients, very small atrial septal defects (<3 mm) were missed. Subjective evaluation of image quality Interobserver agreement was reached in all patients. The average subjective overall image quality score of pro- spective ECG-triggering DSCT was 4.3±0.7 (range 3–5): score 3 (n=4, 11%), score 4 (n=15, 43%) and score 5 (n= 16, 46%). Diagnostic images (images graded 3 or more) were obtained in all examinations. There was good agreement (к=0.78) for overall image quality scoring between the two reviewers. Radiation dose estimations The mean volume CT dose index was 1.39±0.40 mGy (range: 0.83–1.92). The mean dose-length product was 19.86±6.27 mGy·cm (range: 10–32), resulting in an estimated mean effective radiation dose of 0.38±0.09 mSv (range: 0.25–0.58). Radiation dose estimates for each patient in prospective ECG-triggering DSCT angiography are shown in Table 3. Discussion Our study results indicate the technical and clinical feasibility of low-dose prospective ECG-triggering DSCT angiography in infants and children with complex CHD. The accuracy of prospective ECG-triggering DSCT angiog- raphy in diagnosing cardiovascular deformities was 97.3% (142/146). Prospective ECG-triggering DSCT angiograp