中西医结合治疗消化性溃疡研究进展

2 0 0 9 ? ? 23?　? 3? ? ? ? ? ? ? ? ? JOURNAL OF PRACT ICAL TRAD IT IONAL CH IN ESE INTERNAL MED ICINE ?????? ,????????????? ,?? ?????????????。??? [ 16 ]???? ?????辨???????????????? ???? :????? IR?? ,???????? ?、??????。 ????????????????? ,??? ???????、??、??、???????? ,? ????????。???????? ,????? ????????????????? ,????? ?????????????? ,???????? ?????????。???? ,???????? ????????????????。????? ??????????? ,??????????? ??????? ,??????????????? ????????。 ???? [ 1 ]??? .????????? [M ]. ??? . ????????? ? ,????????????? ,????? (?? ) , 2005 [ 2 ]??? .?????????????? [ J ]. ???? , 2005 , 17 (2 ) : 1 - 6 [ 3 ]??? .????????????? [ J ].????????? ?? , 2005, 14 ( 1) : 59 - 63 [ 4 ]Burn sMA , HeW,W u CL, et al. Quantitative p atho logy in tissue MR spectroscopy based human p rostate metabolom ics[ J ]. Technol Cancer Res Treat, 2004 , 3 (6) : 591 [ 5 ]Verhoeckx KC, Bijl sma S, Jespersen S, et al. Characterization of an ti - inflammato ry compound s u sing tran scrip tom ics, p ro teom ics, and metabolom ics in combination wi th mul tivariate data analysis [ J ]. In t Immunopharmcol, 2004, 4 (12 ) : 1499 - 514 [ 6 ]??? ,??? ,???. ?????????????? [ J ].? ????? , 2003, 19 (11) : 1315 - 1317 [ 7 ]Brind le JT, A ntti H, Ho lmes E, et al. Rap id and noninvasive d iagno2 sis of the p resence and severity of co ronary heart d isease u sing 1H - NMR - based metabonom ics[ J ]. NatMed, 2002 , 8 ( 12) : 1439 - 1444 [ 8 ]???.?????? [M ].?? :???????? , 2002: 215 - 216 [ 9 ]??? ,?? ,??? ,?. ???????????????? ???????? [ J ].???? , 2004 , 17 ( 9) : 1 [ 10 ]??? ,?? ,??? ,? .?????????????? [ J ]. ??????? , 2007, 5 ( 3) : 307 [ 11 ]??? ,??? ,??? .????? S447X? H ind????? ??????????????????? [ J ].?????? ?? , 2005, 22 (2 ) : 151 - 157 [ 12 ]Akira, ImachiM , Hash imoto T. Invest igations into biochem ical chan2 ges of genetic hypertensive rats using 1H Nuclear magnetic resonance - based metabonom ics[ J ]. Hypertens Res, 2005, 28 (5 ) : 525 - 530 [ 13 ]Brid le JT, N icholson JK, Schofield PM , et al. App lication of chemo2 metrics to NMR sp ectroscop ic data to investigate a relation sh ip be2 tween human serum metabol ic p rofiles and hyp ertension [ J ]. Analyst, 2003, 128 (1 ) : 32 - 36 [ 14 ]??? ,??? ,??? .????辨???????????? ???? [ J ].???? , 1999 , 40 ( 1) : 45 [ 15 ]??? ,??? ,??? ,? .??????????? , C -?? ????辨?????? [ J ]. ????????? , 2000 , 20 (3) : 190 - 191 [ 16 ]?? ,??? ,??? ,? .??????辨????????? ?????? [ J ].?????? (??? ) , 2005, 43 (2 ) : 142 - 144 (???? : 2008 - 12 - 10) 中 西 医 结 合 治 疗 消 化 性 溃 疡 研 究 进 展 ? ? ? ?? :??? (?????? ,???? 430061) ? 　　　? :????? ,? :??辨????辨???? 、???????????、?????????????、? ???????????????、???????????????????????????。?? :????? ????????????????? ,???????? ,???????。 ? 　? 　? :????? ; ??????? ; ?? ; ?? ????? : R573. 1　????? : A　do i: 10. 3969 / j. issn. 1671 - 7813. 2009. 03. 09 Traditional Chinese andWestern Medic ine Treatment of Pep tic U lce r Research Shen L i - ping, Advisor: Tong Chang - zhen (Hubei College of Traditional ChineseMedicine,Wuhan 430061, Hubei, China) Abstract: From five aspects, namely, TCM and Western medicine disease combining p rop rietary Chinese , f j , f M B 2 , y, f y ?91? m ed ic ine w ith w e ste rn m ed ic ine com b ine d w ith w e ste rn m edic ine C h ine se m ed ic in e trea tm e nt o p a rtia l o in t tre a tm en t app lic a tio n o m ode rn m ed ic a l th eo rie s to gu ide the C h ine se e dic ine P ra c titione r s oa rd to m ed ic a tion the rap suc h a s a cup unc tu re and em be dd ing tra ditio na l C h ine se a nd w e ste rn m ed ic in e on the trea tm en t o pep tic u lce r re se a rc h. Po in te d ou t: trad ition a l C hin e se a nd w e ste rn m ed ic ine ca n k eep the o r igina l so le l ba se d ? ? ? ? ? ? ? ? JOURNAL OF PRACT ICAL TRAD IT IONAL CH IN ESE INTERNAL MED ICINE Nov . 2 0 0 9 Vo l. 2 3　No. 3 on the efficacy ofwe stern medic ine to improve the qua lity of ulcer hea ling and reduce the side effects ofwest2 ern medicine. KeyWords: peptic ulcer; traditiona l Chinese and western medicine; progress; exposition 　　????? ,???????????? ,?? ?????????、??? ,????????? ?? ,??????????。???????“? ?? ”?? ,????????????????? ??。??????????????????? ???????????。????? : 1 ??辨????辨???? ???????????舌??? ,????? ??? ,辨????? ,???????????? ??? ,????辨??????。??????? ?????、??、????????? ,????辨 ????辨????? ,???????? ,??? ??????????。???? [ 1]?????? ??? Hp???????? 49??????? ?、?????、?????、??????? ,?? ??????? ,????? ,????????? ???、????、??? ,?????????。4 ???????? ,??????? ( 96. 6% )?? ??? ( 55. 0% ) ,???????? (χ2 = 4. 47, P < 0. 05)。??? [2 ]? Hp???????? 52? ???????、?????、????????? , ????????? ,????????????、 ????、???? ,??????????。?? ????????? 1? ,??????????? ???????? ( P < 0. 01) ;???????? ????? ( P <0. 01)。?? ,???????? ? ,????????????? ,??????? ? ,???????。 ?? ,???? [3 ]?? ,?????????? , ????????? ,??????? ,????? ???????? ,?????????? ,??? ? ,?????? ,???????、?????? ?。?? ,?????? ,??????? ,???? ?? ,??????????????。 2 ??????????? ?? [4 ]????????????? (??? ? )、?????????????? ,????? ?????????。?? :????????? , ????? Hp????????????? ( P > 0. 05) ,??? 6??? ,??? 64???? 5? ,? ??? 7. 81% ,???? 32?? 7??? ,??? ? 21. 88% ,?????????? ( P <0. 01)。? ????????????????????? ,? ??????。???? [5 ]????? (??? )、 ???? (??????????????? )、? ?????? (??????? )???????? ?? ,?? ? ,???? 3?。?? ??? ???????? 26. 67% ;??? Hp???? 9. 38% ,?????? 12. 50% ;?????? Hp? ???????? 6. 25%。?????????? ?? ,???????? ( P < 0. 05)。????? ?????????????????????。 ?? [6 ]??? ,???????????? ,??? ?? (88. 2% )? 6? 9???????????? ?????????????????。 3 ????????????? ???????????? ,???????? ??? ,?????????????????? ? ,?????辨???????? ,?????? ????????。????????????? ?????????????????????? ???。????、???、?????、????、 ???、??? ,?????、???、???、??? ???。?????????、????????? ???? [7 ]。??? [8 ]???????????? ???? ,????????????????? ? ,??????????。?? :??????? ? (??? 96. 7% ,??? 80. 0% )????? (? ?? 100% ,??? ( 86. 7% )??????? ( P < 0. 05)。??? [9 ]??????????????? ????? (??、??、??、?黛、?????? , ???? , ???? ) ,???????? ,???? ??? 33? , ??? 29?。????????? ?祛? ,????????????? ,????? ??????? ,?????? ,???????? , ???????。 4 ???????????????? ????????、???、???。???? ??????辨??? ,???、?????辨?? ?。??????????、????、????? ? ,??? [ 10]?????? ,????、??、??、 ??、??、???、???、??、??、???、?? ??。?? 210???????? ,???? 86% , ????? 98%。???、?????????? , ??????? ,?????辨??? ,???辨? ???????????????。“????? , ?????? ”“????? ,?????? ”?? ?。???????????????、????? ?????? ,???????。 ???? ,????????????、? Hp、 ?????、???????????。??? [ 11 ] ??? ,????? (???、??、?? )???? ?、?????、??????????????? ?????????? ( < ) ,?????? ?02? Hp : Hp P 0. 0 1 2 0 0 9 ? ? 23?　? 3? ? ? ? ? ? ? ? ? JOURNAL OF PRACT ICAL TRAD IT IONAL CH IN ESE INTERNAL MED ICINE ?????????? ( P < 0. 01)??????? ( P <0. 05) ,????????。??? [ 12 ]??? ??????????????????? Hp? ??? ,????????????????? ,? ???????? ,??????? 2. 5g/L。? ? [ 13 ]????? (??、??、??? )?????? ??? ,??????????????????? ?????????? PGE2??? ,?????? ?????????? ,???????????? ??? PG????? ,???????? ,??? ???????????。??? [14]?????? ?????????????? ,???????? ????????????????。?? [15]?? ? :????、??、???、??、???、???? ??????????????????? ,??? ???????。??? [ 16 ]??? ,?????? ??????????? ,?????? ,???? ????? ,???????? ,????。 5 ??????? ?????? :?????????????? ?????、????、?????????。?? ?? [17]????、??、??????? BD8998? ????????辨?????????? 32? , ????????? 32??????。?? : ?? ????? 96. 8% ,??????? 81. 2% ( P <0. 05)。??????????????????? ?? ,?? Hp??? ;???????????? , ??????????? ,???????。??? ? [ 18 ]???? :???、?? ,??????? ;?? ???。????? (??、??、??、???、? ???? ) ????????????? 33? ,? ???咪???? 30?????? ,?????? ??? 87. 88% ,??????? 63. 33% ( P < 0. 05)。???? [ 19 ]????????? ,?? :?? ? (? )、??、?????、??? (? )、??、?? , ????????? (????、????、???、 ???? )??????? 50? ,??????? ?? 50 ??????。?? : ??????? 94% ,??????? 80% ( P <0. 05)。?? [ 20]? ??????????????? 218? ,???? ? (?? )???? (?? )、????????? ,? 6???? ,?????? 1?7???????? , ?????? ,?????。 6 ????? ???????????? :???????? ?????????? ,???????????? ???????????? ,????????、? ????? ,???????。????????? ??????????? ,???????? ,?? ???????。?? ,???????????? ?? ,?????? ,????????? ,???? ??????。 ?????????辨??? ,???辨??? ?????。???????? ,???????? ???? ,???????。????辨????? ????????????? ,????????? ????????????? ,????????? ????????。????????????? ????????????? ,????????? ? ,??????。???? ,??????? ,?? ????? ,?????????? ,?????? ??????????????。??????? ???? ,????????? ,???????? ?。 ???? [ 1 ]??? ,???. ?????????????? [ J ]. ???? ???? , 2008, 5 (2 ) : 79 [ 2 ]???. ????????????????? [J ]. Wo rld Heath D igest, 2007 , 4 (3) :112 [ 3 ]??? ,??. ?????辨??? [ J ]. ?????????? ? , 2000, 8 ( 4) : 229 [ 4 ]??. ???????????????? 64? [ J ]. ???? ????? , 2002, 15 (11) : 14 - 18 [ 5 ]??? ,??? ,??? ,? . ??????????????? ????????????? [ J ]. ??????????? , 2001, 9 ( 1) : 23 - 25 [ 6 ]?? ,??? ,??? ,?. ???????????????? ? [ J ].????????? , 2004 , 20 ( 3) : 152 - 154 [ 7 ]??? . ???????????????? [ J ]. ???? , 1995, 12: 746 [ 8 ]???. ??????????????? 30? [ J ]. ???? ???? , 2000, 24 ( 3) : 39 [ 9 ]??? ,?. ?????????????????????? ? [ J ].????????? , 1994 , 14 ( 11 ) : 679 [ 10 ]???. ????????????????? [ J ]. ???? , 2008, 5 (9 ) : 71 [ 11 ]??? ,??? ,???. ??????????? [ J ]. ??? ??? , 2000, 11 (1 ) : 11 - 12 [ 12 ]??? ,??? ,?? ,? .???????????????? ?????? [ J ].???? , 1999, 27 (3 ) : 158 - 159 [ 13 ]?? . ??????????? [ J ]. ????????? , 2000, 9 (6 ) : 471 - 472 [ 14 ]??? ,??? ,??? ,? .??????????????? ????? [ J ].???? , 2000 , 26 ( 1) : 44 - 45 [ 15 ]?? ,??. ????????????????? [ J ]. ??? ????? , 1997, 13 (3) : 301 - 316 [ 16 ]??? ,??? ,??? .????????????????? ??? [ J ].??????????? , 2000, 8 (5 ) : 278 - 280 [ 17 ]??? ,??? ,?? ,? .?????????辨?????? ?? 32? [ J ]. ????? , 1997, 8 (3) : 7 [ 18 ]??? ,??? ,??? ,? .??????????????? ? [ J ].???? , 2001 , 21 ( 1) : 7 - 8 [ ]??? ,??? ????????????????? 5 ? [ ] ??? , , 33 ( 6) 3 3 [ ]?? ?????????????? ? [ ] ????? ? , , ( ) (???? ) ?12? 19 . 0 J . 2002 : 47 - 48 20 . 218 J . 2002 21 2 : 141 : 200 8 - 08 - 29