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35歲之婦女,其終生得乳癌之 機率=p, 不會得乳癌之機率=1- p 11 3. 生第一胎的<20歲之婦女,其終生得 乳癌之機率=p, 不會得乳癌之機率=1- p 22 4. 男性肺腺癌患者接受化學治療一個療程後存活時間超過3 年的機率=s, <3年的機率=1-s。 Comment: In most of the cases, the probability of a concerned event differs if the definition of that event varies with different populations, time, space, or other characteristics. For example, the probability of becoming as an incidence case of breast cancer depends on the „age? of a female individual, as well as on her lifestyle, family history, genetic susceptibility, etc. Further, a male lung-cancer patient?s 3-year survival also depends on his personal characteristics; including past history of cigarette smoking or relevant exposure, occupation, genetic factors, cancer?s stage, and many others. So, the problem is complicated, which usually necessitate a complicated analysis tool and statistical „model? to explore it. Expectation and Variance (期望值與變異數) of a Bernoulli random variable: X~Ber(p) EX =1•P(X=1)+0•P(X=0) =1•p+0•(1-p)= p 22 2Var(X)=E[(X-EX)]=E(X-2•X•EX+[EX]) 2 2= E(X)- 2•EX•EX+(EX) 22=E(X)-(EX), 222but E(X)= 1•P(X=1)+0•P(X=0)= p 2?Var(X)=p-p= p(1-p) The Binomial Distribution Notation: Bin(n,p) Question If there are n independent Bernoulli trials X, =1 (probb.=p); =0 (probb.=1-p) 1 X, =1 (probb.=p); =0 (probb.=1-p) 2 …. X =1 (probb.=p); =0 (probb.=1-p) n, +) ΣX=???? i ----------------------------------------------------------- ANS: P(ΣX=0)=(1-p)(1-p)(1-p)...(1-p) i P(ΣX=1)= p (1-p)(1-p)...(1-p)+ i (1-p) p (1-p)...(1-p)+ (1-p)(1-p) p (1-p)…(1-p)+ …….+ (1-p)(1-p)...(1-p) p 1n-1 = np(1-p) 1n-1 = nC p(1-p)1 …, it can be derived similarly for other values of ΣX i Formulae xn-xP(ΣX=x) = nC p(1-p), x=0,1,2,…,n; 0
0 In order to check that it is a probb. distribution:
-λxΣeλ/x! =1,所有的可能加起來必須等於1 x
Expectation and Variance
E(X)=λ and Var(X)=λ
Normal (Gaussian) Distribution
常態分布,高斯分布
Figure
μ
μ-σ μ+σ Table μ-2σ μ+2σ
Formulae
22
f(x)=[1/σ?(2π)]exp[(x-μ)/-2σ]
In order to check that f(x) is a p.d.f. (probability
density function), note that ? f(x)dx=1. Expectation and Variance
E(X)=? xf(x)dx=μ
2Var(X)=E[(X-EX)]
2= E[(X-μ)]
2 2=E(X)-(EX)
22 = E(X)- μ
22=? xf(x)dx- μ
222 =(μ+σ) - μ
2=σ
Characteristics
1. Bell-shaped,鐘形分布,
2. Symmetric about the mean μ (對稱性)
3. mean=median=mode
224. If X~Normal (μ, σ), or simply N(μ, σ),
P(μ,σ,X,μ,σ) ? 0.68
P(μ,2σ,X,μ,2σ) ? 0.95
Standardization:
Z=X-μ/σ
2f(z)=[1/?(2π)]exp[z/-2]
(See Figures 7.8~7.11)
P(-1,Z,1) ? 0.68 (exactly, =0.6826)
P(-2,Z,2) ? 0.95 (exactly, =0.9544)
Moreover,
P(-1.96