直肠癌所有化疗药物-2011

Adrucil(fluorouracil,5-FU)Adrucilisachemotherapydrugthatinterfereswiththegrowthofcancercells.Itcanbeusedtotreatmanytypesofcancers,includingcancerofthecolon,rectum,breast,stomach,head,andneck.FLUOROURACIL,5-FUisachemotherapydrug.Itslowsthegrowthofcancercells.Thismedicineisusedtotreatmanytypesofcancerlikebreastcancer,colonorrectalcancer,pancreaticcancer,andstomachcancer.Thismedicinemaybeusedforotherpurposes;askyourhealthcareproviderorpharmacistifyouhavequestions.Yourhealthcareproviderneedstoknowifyouhaveanyoftheseconditions:•blooddisorders•dihydropyrimidinedehydrogenase(DPD)deficiency•infection(especiallyavirusinfectionsuchaschickenpox,coldsores,orherpes)•kidneydisease•liverdisease•malnourished,poornutrition•recentorongoingradiationtherapy•anunusualorallergicreactiontofluorouracil,otherchemotherapy,othermedicines,foods,dyes,orpreservatives•pregnantortryingtogetpregnant•breast-feedingSideeffectsthatyoushouldreporttoyourdoctororhealthcareprofessionalassoonaspossible:•allergicreactionslikeskinrash,itchingorhives,swellingoftheface,lips,ortongue•lowbloodcounts-thismedicinemaydecreasethenumberofwhitebloodcells,redbloodcellsandplatelets.Youmaybeatincreasedriskforinfectionsandbleeding.•signsofinfection-feverorchills,cough,sorethroat,painordifficultypassingurine•signsofdecreasedplateletsorbleeding-bruising,pinpointredspotsontheskin,black,tarrystools,bloodintheurine•signsofdecreasedredbloodcells-unusuallyweakortired,faintingspells,lightheadedness•breathingproblems•changesinvision•chestpain•mouthsores•nauseaandvomiting•pain,swelling,rednessatsitewhereinjected•pain,tingling,numbnessinthehandsorfeet•redness,swelling,orsoresonhandsorfeet•stomachpain•unusualbleedingSideeffectsthatusuallydonotrequiremedicalattention(reporttoyourdoctororhealthcareprofessionaliftheycontinueorarebothersome):•changesinfingerortoenails•diarrhea•dryoritchyskin•hairloss•headache•lossofappetite•sensitivityofeyestothelight•stomachupset•unusuallytearyeyesSideEffectThislistmaynotdescribeallpossiblesideeffects.Callyourdoctorformedicaladviceaboutsideeffects.YoumayreportsideeffectstoFDAat1-800-FDA-1088.Visityourdoctorforchecksonyourprogress.Thisdrugmaymakeyoufeelgenerallyunwell.Thisisnotuncommon,aschemotherapycanaffecthealthycellsaswellascancercells.Reportanysideeffects.Continueyourcourseoftreatmenteventhoughyoufeelillunlessyourdoctortellsyoutostop.Insomecases,youmaybegivenadditionalmedicinestohelpwithsideeffects.Followalldirectionsfortheiruse.Callyourdoctororhealthcareprofessionalforadviceifyougetafever,chillsorsorethroat,orothersymptomsofacoldorflu.Donottreatyourself.Thisdrugdecreasesyourbody'sabilitytofightinfections.Trytoavoidbeingaroundpeoplewhoaresick.Thismedicinemayincreaseyourrisktobruiseorbleed.Callyourdoctororhealthcareprofessionalifyounoticeanyunusualbleeding.Becarefulbrushingandflossingyourteethorusingatoothpickbecauseyoumaygetaninfectionorbleedmoreeasily.Ifyouhaveanydentalworkdone,tellyourdentistyouarereceivingthismedicine.Avoidtakingproductsthatcontainaspirin,acetaminophen,ibuprofen,naproxen,orketoprofenunlessinstructedbyyourdoctor.Thesemedicinesmayhideafever.Donotbecomepregnantwhiletakingthismedicine.Womenshouldinformtheirdoctoriftheywishtobecomepregnantorthinktheymightbepregnant.Thereisapotentialforserioussideeffectstoanunbornchild.Talktoyourhealthcareprofessionalorpharmacistformoreinformation.Donotbreast-feedaninfantwhiletakingthismedicine.Menshouldinformtheirdoctoriftheywishtofatherachild.Thismedicinemaylowerspermcounts.Donottreatdiarrheawithoverthecounterproducts.Contactyourdoctorifyouhavediarrheathatlastsmorethan2daysorifitissevereandwatery.Thismedicinecanmakeyoumoresensitivetothesun.Keepoutofthesun.Ifyoucannotavoidbeinginthesun,wearprotectiveclothingandusesunscreen.Donotusesunlampsortanningbeds/booths.HowshouldIusethismedicine?Thisdrugisgivenasaninfusionorinjectionintoavein.Itisadministeredinahospitalorclinicbyaspeciallytrainedhealthcareprofessional.Talktoyourpediatricianregardingtheuseofthismedicineinchildren.Specialcaremaybeneeded.Overdosage:Ifyouthinkyouhavetakentoomuchofthismedicinecontactapoisoncontrolcenteroremergencyroomatonce.NOTE:Thismedicineisonlyforyou.Donotsharethismedicinewithothers.WhatifImissadose?Itisimportantnottomissyourdose.Callyourdoctororhealthcareprofessionalifyouareunabletokeepanappointment.Eloxatin(oxaliplatin)Eloxatinisalsoachemotherapydrugthatkillscancercells.It'susedtotreatcolorectalcancerandcanbeadministeredbyitselforwithotherchemotherapydrugs.OXALIPLATINisachemotherapydrug.Ittargetsfastdividingcells,likecancercells,andcausesthesecellstodie.Thismedicineisusedtotreatcancersofthecolonandrectum,andmanyothercancers.Thismedicinemaybeusedforotherpurposes;askyourhealthcareproviderorpharmacistifyouhavequestions.Yourhealthcareproviderneedstoknowifyouhaveanyoftheseconditions:•kidneydisease•anunusualorallergicreactiontooxaliplatin,otherchemotherapy,othermedicines,foods,dyes,orpreservatives•pregnantortryingtogetpregnant•breast-feedingSideeffectsthatyoushouldreporttoyourdoctororhealthcareprofessionalassoonaspossible:•allergicreactionslikeskinrash,itchingorhives,swellingoftheface,lips,ortongue•lowbloodcounts-Thisdrugmaydecreasethenumberofwhitebloodcells,redbloodcellsandplatelets.Youmaybeatincreasedriskforinfectionsandbleeding.•signsofinfection-feverorchills,cough,sorethroat,painordifficultypassingurine•signsofdecreasedplateletsorbleeding-bruising,pinpointredspotsontheskin,black,tarrystools,nosebleeds•signsofdecreasedredbloodcells-unusuallyweakortired,faintingspells,lightheadedness•breathingproblems•chestpain,pressure•cough•diarrhea•jawtightness•mouthsores•nauseaandvomiting•pain,swelling,rednessorirritationattheinjectionsite•pain,tingling,numbnessinthehandsorfeet•problemswithbalance,talking,walking•redness,blistering,peelingorlooseningoftheskin,includinginsidethemouth•troublepassingurineorchangeintheamountofurineSideeffectsthatusuallydonotrequiremedicalattention(reporttoyourdoctororhealthcareprofessionaliftheycontinueorarebothersome):•changesinvision•constipation•hairloss•lossofappetite•metallictasteinthemouthorchangesintaste•stomachpainSideEffectThislistmaynotdescribeallpossiblesideeffects.Callyourdoctorformedicaladviceaboutsideeffects.YoumayreportsideeffectstoFDAat1-800-FDA-1088.Yourconditionwillbemonitoredcarefullywhileyouarereceivingthismedicine.Youwillneedimportantbloodworkdonewhileyouaretakingthismedicine.Thismedicinecanmakeyoumoresensitivetocold.Donotdrinkcolddrinksoruseice.Coverexposedskinbeforecomingincontactwithcoldtemperaturesorcoldobjects.Whenoutincoldweatherwearwarmclothingandcoveryourmouthandnosetowarmtheairthatgoesintoyourlungs.Tellyourdoctorifyougetsensitivetothecold.Thisdrugmaymakeyoufeelgenerallyunwell.Thisisnotuncommon,aschemotherapycanaffecthealthycellsaswellascancercells.Reportanysideeffects.Continueyourcourseoftreatmenteventhoughyoufeelillunlessyourdoctortellsyoutostop.Insomecases,youmaybegivenadditionalmedicinestohelpwithsideeffects.Followalldirectionsfortheiruse.Callyourdoctororhealthcareprofessionalforadviceifyougetafever,chillsorsorethroat,orothersymptomsofacoldorflu.Donottreatyourself.Thisdrugdecreasesyourbody'sabilitytofightinfections.Trytoavoidbeingaroundpeoplewhoaresick.Thismedicinemayincreaseyourrisktobruiseorbleed.Callyourdoctororhealthcareprofessionalifyounoticeanyunusualbleeding.Becarefulbrushingandflossingyourteethorusingatoothpickbecauseyoumaygetaninfectionorbleedmoreeasily.Ifyouhaveanydentalworkdone,tellyourdentistyouarereceivingthismedicine.Avoidtakingproductsthatcontainaspirin,acetaminophen,ibuprofen,naproxen,orketoprofenunlessinstructedbyyourdoctor.Thesemedicinesmayhideafever.Donotbecomepregnantwhiletakingthismedicine.Womenshouldinformtheirdoctoriftheywishtobecomepregnantorthinktheymightbepregnant.Thereisapotentialforserioussideeffectstoanunbornchild.Talktoyourhealthcareprofessionalorpharmacistformoreinformation.Donotbreast-feedaninfantwhiletakingthismedicine.InteractionThefollowingdrugsmayinteractwithEloxatin®:•medicinestoincreasebloodcountslikefilgrastim,pegfilgrastim,sargramostim•probenecid•someantibioticslikeamikacin,gentamicin,neomycin,polymyxinB,streptomycin,tobramycin•zalcitabineTalktoyourdoctororhealthcareprofessionalbeforetakinganyofthesemedicines:•acetaminophen•aspirin•ibuprofen•ketoprofen•naproxenThislistmaynotdescribeallpossibleinteractions.Giveyourhealthcareprovideralistofallthemedicines,herbs,non-prescriptiondrugs,ordietarysupplementsyouuse.Alsotellthemifyousmoke,drinkalcohol,oruseillegaldrugs.Someitemsmayinteractwithyourmedicine.UsageHowshouldIusethismedicine?Thisdrugisgivenasaninfusionintoavein.Itisadministeredinahospitalorclinicbyaspeciallytrainedhealthcareprofessional.Talktoyourpediatricianregardingtheuseofthismedicineinchildren.Specialcaremaybeneeded.Overdosage:Ifyouthinkyouhavetakentoomuchofthismedicinecontactapoisoncontrolcenteroremergencyroomatonce.NOTE:Thismedicineisonlyforyou.Donotsharethismedicinewithothers.WhatifImissadose?Itisimportantnottomissadose.Callyourdoctororhealthcareprofessionalifyouareunabletokeepanappointment.Erbitux(cetuximab)Erbituxtargetsatypeofprotein(EGFR)that'spresentonthesurfaceofcolorectalcancercells.Ultimately,Erbituxinterfereswiththegrowthofthesecellsandcausesthemtodie.CETUXIMABisachemotherapydrug.Ittargetsaspecificproteinwithincancercellsandstopsthecellsfromgrowing.Itisusedtotreatcolorectalcancerandheadandneckcancer.Thismedicinemaybeusedforotherpurposes;askyourhealthcareproviderorpharmacistifyouhavequestions.Yourhealthcareproviderneedstoknowifyouhaveanyoftheseconditions:•heartdisease•heartfailure•lungdisease,especiallylungfibrosis•anunusualorallergicreactiontocetuximab,mouseproteins,othermedicines,foods,dyes,orpreservatives•pregnantortryingtogetpregnant•breast-feedingSideEffectsSideeffectsthatyoushouldreporttoyourdoctororhealthcareprofessionalassoonaspossible:•allergicreactionslikeskinrash,itchingorhives,swellingoftheface,lips,ortongue•breathingproblems•changesinvision•fast,irregularheartbeat•feelingfaintorlightheaded,falls•fever,chills•mouthsores•troublepassingurineorchangeintheamountofurine•unusuallyweakortiredSideeffectsthatusuallydonotrequiremedicalattention(reporttoyourdoctororhealthcareprofessionaliftheycontinueorarebothersome):•changesinskinlikeacne,cracks,skindryness•constipation•diarrhea•headache•nailchanges•nausea,vomiting•stomachupset•weightlossThislistmaynotdescribeallpossiblesideeffects.Callyourdoctorformedicaladviceaboutsideeffects.YoumayreportsideeffectstoFDAat1-800-FDA-1088.Visityourdoctorforchecksonyourprogress.Thisdrugmaymakeyoufeelgenerallyunwell.Thisisnotuncommon,aschemotherapycanaffecthealthycellsaswellascancercells.Reportanysideeffects.Continueyourcourseoftreatmenteventhoughyoufeelillunlessyourdoctortellsyoutostop.Thismedicinecanmakeyoumoresensitivetothesun.Keepoutofthesunwhiletakingthismedicineandfor2monthsafterthelastdose.Ifyoucannotavoidbeinginthesun,wearprotectiveclothingandusesunscreen.Donotusesunlampsortanningbeds/booths.Insomecases,youmaybegivenadditionalmedicinestohelpwithsideeffects.Followalldirectionsfortheiruse.Callyourdoctororhealthcareprofessionalforadviceifyougetafever,chillsorsorethroat,orothersymptomsofacoldorflu.Donottreatyourself.Thisdrugdecreasesyourbody'sabilitytofightinfections.Trytoavoidbeingaroundpeoplewhoaresick.Avoidtakingproductsthatcontainaspirin,acetaminophen,ibuprofen,naproxen,orketoprofenunlessinstructedbyyourdoctor.Thesemedicinesmayhideafever.Donotbecomepregnantwhiletakingthismedicine.Womenshouldinformtheirdoctoriftheywishtobecomepregnantorthinktheymightbepregnant.Thereisapotentialforserioussideeffectstoanunbornchild.Useadequatebirthcontrolmethods.Avoidpregnancyforatleast6monthsafteryourlastdose.Talktoyourhealthcareprofessionalorpharmacistformoreinformation.Donotbreast-feedaninfantwhiletakingthismedicineorduringthe2monthsafteryourlastdose.InteractionsInteractionsarenotexpected.UsagesHowshouldIusethismedicine?Thisdrugisgivenasaninfusionintoavein.Itisadministeredinahospitalorclinicbyaspeciallytrainedhealthcareprofessional.Talktoyourpediatricianregardingtheuseofthismedicineinchildren.Specialcaremaybeneeded.Overdosage:Ifyouthinkyouhavetakentoomuchofthismedicinecontactapoisoncontrolcenteroremergencyroomatonce.NOTE:Thismedicineisonlyforyou.Donotsharethismedicinewithothers.WhatifImissadose?Itisimportantnottomissyourdose.Callyourdoctororhealthcareprofessionalifyouareunabletokeepanappointment.Vectibix(panitumumab)VectibixactsinasimilarmannertoErbituxbutismadebyadifferentcompany(Amgen).VectibixtargetscellsthathaveEGFRproteinsandinterfereswiththeirabilitytosurvive.Wellcovorin(leucovorin)Wellcovorinisavitamincomplexusedtotreatadvancedcoloncancer.Byitself,Wellcovorinisn'tabletofightcanceratall.Rather,ithelpspatientsbyincreasingtheeffectivenessofanotherdrug,fluorouracil.ThinkyoualreadyknowalotaboutWellcovorin?Testyourknowledgewiththeseleucovorinquizzes.Xeloda(capecitabine)Xelodaisachemotherapydrugthatdecreasesthesizeoftumors.Itcomesintabletformandisusedtotreatbreastandcolorectalcancer.CAPECITABINEisachemotherapydrug.Itslowsthegrowthofcancercells.Thismedicineisusedtotreatbreastcancer,andalsocolonorrectalcancer.Thismedicinemaybeusedforotherpurposes;askyourhealthcareproviderorpharmacistifyouhavequestions.Yourhealthcareproviderneedstoknowifyouhaveanyoftheseconditions:•bleedingorblooddisorders•dihydropyrimidinedehydrogenase(DPD)deficiency•heartdisease•infection(especiallyavirusinfectionsuchaschickenpox,coldsores,orherpes)•kidneydisease•liverdisease•anunusualorallergicreactiontocapecitabine,5-fluorouracil,othermedicines,foods,dyes,orpreservatives•pregnantortryingtogetpregnant•breast-feedingSideeffectsthatyoushouldreporttoyourdoctororhealthcareprofessionalassoonaspossible:•allergicreactionslikeskinrash,itchingorhives,swellingoftheface,lips,ortongue•lowbloodcounts-thismedicinemaydecreasethenumberofwhitebloodcells,redbloodcellsandplatelets.Youmaybeatincreasedriskforinfectionsandbleeding.•signsofinfection-feverorchills,cough,sorethroat,painordifficultypassingurine•signsofdecreasedplateletsorbleeding-bruising,pinpointredspotsontheskin,black,tarrystools,bloodintheurine•signsofdecreasedredbloodcells-unusuallyweakortired,faintingspells,lightheadedness•breathingproblems•changesinvision•chestpain•diarrheaofmorethan4bowelmovementsinonedayoranydiarrheaatnight•mouthsores•nauseaandvomiting•pain,swelling,rednessatsitewhereinjected•pain,tingling,numbnessinthehandsorfeet•redness,swelling,orsoresonhandsorfeet•stomachpain•vomiting•yellowcolorofskinoreyesSideeffectsthatusuallydonotrequiremedicalattention(reporttoyourdoctororhealthcareprofessionaliftheycontinueorarebothersome):•constipation•diarrhea•dryoritchyskin•hairloss•lossofappetite•nausea•weakortiredSideEffectThislistmaynotdescribeallpossiblesideeffects.Callyourdoctorformedicaladviceaboutsideeffects.YoumayreportsideeffectstoFDAat1-800-FDA-1088.Visityourdoctorforchecksonyourprogress.Thisdrugmaymakeyoufeelgenerallyunwell.Thisisnotuncommon,aschemotherapycanaffecthealthycellsaswellascancercells.Reportanysideeffects.Continueyourcourseoftreatmenteventhoughyoufeelillunlessyourdoctortellsyoutostop.Insomecases,youmaybegivenadditionalmedicinestohelpwithsideeffects.Followalldirectionsfortheiruse.Callyourdoctororhealthcareprofessionalforadviceifyougetafever,chillsorsorethroat,orothersymptomsofacoldorflu.Donottreatyourself.Thisdrugdecreasesyourbody'sabilitytofightinfections.Trytoavoidbeingaroundpeoplewhoaresick.Thismedicinemayincreaseyourrisktobruiseorbleed.Callyourdoctororhealthcareprofessionalifyounoticeanyunusualbleeding.Becarefulbrushingandflossingyourteethorusingatoothpickbecauseyoumaygetaninfectionorbleedmoreeasily.Ifyouhaveanydentalworkdone,tellyourdentistyouarereceivingthismedicine.Avoidtakingproductsthatcontainaspirin,acetaminophen,ibuprofen,naproxen,orketoprofenunlessinstructedbyyourdoctor.Thesemedicinesmayhideafever.Donotbecomepregnantwhiletakingthismedicine.Womenshouldinformtheirdoctoriftheywishtobecomepregnantorthinktheymightbepregnant.Thereisapotentialforserioussideeffectstoanunbornchild.Talktoyourhealthcareprofessionalorpharmacistformoreinformation.Donotbreast-feedaninfantwhiletakingthismedicine.Menareadvisednottofatherachildwhiletakingthismedicine.InteractionsThefollowingdrugsmayinteractwithXeloda®:•antacidswithaluminumand/ormagnesium•folicacid•leucovorin•medicinestoincreasebloodcountslikefilgrastim,pegfilgrastim,sargramostim•phenytoin•vaccines•warfarinTalktoyourdoctororhealthcareprofessionalbeforetakinganyofthesemedicines:•acetaminophen•aspirin•ibuprofen•ketoprofen•naproxenUsagesHowshouldIusethismedicine?Takethismedicinebymouthwithaglassofwater,within30minutesoftheendofameal.Followthedirectionsontheprescriptionlabel.Takeyourmedicineatregularintervals.Donottakeitmoreoftenthandirected.Donotstoptakingexceptonyourdoctor'sadvice.Yourdoctormaywantyoutotakeacombinationof150mgand500mgtabletsforeachdose.Itisveryimportantthatyouknowhowtocorrectlytakeyourdose.Takingthewrongtabletscouldresultinanoverdose(toomuchmedication)orunderdose(toolittlemedication).Apatientinformationsheetfortheproductwillbegivenwitheachprescriptionandrefill.Readthissheetcarefullyeachtime.Thesheetmaychangefrequently.Talktoyourpediatricianregardingtheuseofthismedicineinchildren.Specialcaremaybeneeded.Overdosage:Ifyouthinkyouhavetakentoomuchofthismedicinecontactapoisoncontrolcenteroremergencyroomatonce.NOTE:Thismedicineisonlyforyou.Donotsharethismedicinewithothers.WhatifImissadose?Ifyoumissadose,donottakethemisseddoseatall.Donottakedoubleorextradoses.Instead,continuewithyournextscheduleddoseandcheckwithyourdoctor.