SVHC-06 三氧化二砷 Diarsenic Trioxide_publication(C 致癌)

SVHC SUPPORT DOCUMENT Substance name: Diarsenic Trioxide EC number: 215-481-4 CAS number: 1327-53-3 MEMBER STATE COMMITTEE SUPPORT DOCUMENT FOR IDENTIFICATION OF DIARSENIC TRIOXIDE AS A SUBSTANCE OF VERY HIGH CONCERN Adopted on 1 October 2008 SVHC SUPPORT DOCUMENT 1 CONTENTS JUSTIFICATION .........................................................................................................................................................3 1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES .................................3 1.1 Name and other identifiers of the substance ...................................................................................................3 1.2 Composition of the substance .........................................................................................................................3 1.3 Physico-chemical properties ...........................................................................................................................4 2 CLASSIFICATION AND LABELLING ...............................................................................................................4 2.1 Classification in Annex I of Directive 67/548/EEC........................................................................................4 REFERENCES .............................................................................................................................................................5 TABLES Table 1: Summary of physico- chemical properties .....................................................................................................4 SVHC SUPPORT DOCUMENT 2 Substance Name: Diarsenic Trioxide EC Number: 215-481-4 CAS number: 1327-53-3 • The substance is identified as a CMR according to Article 57 (a) of Regulation (EC) No 1907/2006 (REACH). Summary of the evaluation: According to Annex I to Directive 67/548/EEC Diarsenic Trioxide is classified as a carcinogen Cat. 1 (R 45: May cause cancer). SVHC SUPPORT DOCUMENT 3 JUSTIFICATION 1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES 1.1 Name and other identifiers of the substance Chemical Name: Diarsenic Trioxide EC Name: 215-481-4 CAS Number: 1327-53-3 IUPAC Name: dioxodiarsoxane 1.2 Composition of the substance Chemical Name: Diarsenic trioxide EC Number: 215-481-4 CAS Number: 1327-53-3 IUPAC Name: dioxodiarsoxane Molecular Formula: As2O3 Structural Formula: Molecular Weight: 197.84 Typical concentration (% w/w): >= 99% Concentration range (% w/w): See typical concentration SVHC SUPPORT DOCUMENT 4 1.3 Physico-chemical properties Table 1: Summary of physico- chemical properties 2 CLASSIFICATION AND LABELLING 2.1 Classification in Annex I of Directive 67/548/EEC Diarsenic trioxide has been classified according to the 19th ATP, updated in the 25th ATP, of Directive 67/548/EEC as: Carc. Cat. 1; R45 - T+; R28 - C; R34 - N; R50-53. It has been included in the Annex I of the Directive 67/548/EEC under index number: 033-003-00- 0. REACH ref Annex, § Property IUCLID section Value VII, 7.1 Physical state at 20°C and 101.3 kPa 4.1 Solid VII, 7.2 Melting/freezing point 4.2 315°C/193°C VII, 7.3 Boiling point 4.3 477°C VII, 7.5 Vapour pressure 4.6 850.10-12 hPa at 20°C VII, 7.7 Water solubility 4.8 VII, 7.8 Partition coefficient n- octanol/water (log value) 4.7 partition coefficient No data available XI, 7.16 Dissociation constant 4.21 SVHC SUPPORT DOCUMENT 5 REFERENCES ECB ClassLab database http://ecb.jrc.it/classification-labelling/search-classlab/ Fiche toxicologique de l’INRS FT89 : Trioxyde de diarsenic. 2006 Annex I of Directive 97/548/EEC Commission Directive 2006/139/EC of 20 December 2006 amending Council Directive 76/769/EEC as regards restrictions on the marketing and use of arsenic compounds for the purpose of adapting its Annexe I to technical progress, 2006. INERIS - Fiche de données toxicologiques et environnementales des substances chimiques : Arsenic et ses dérivés inorganiques. 2006 European Commission (2000) IUCLID Dataset, CAS 1327-53-3, 18.2.2000.