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nullImmunoglobulin: Isotypes, Allotypes and IdiotypesImmunoglobulin: Isotypes, Allotypes and IdiotypesImmunoglobulin IsotypesImmunoglobulin IsotypesDefinition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chainsnullHuman IgMantiserumReacts with IgM, IgG, IgA, IgD, IgEReact with IgG, IgA, IgD and IgEAbsorbed antiserumReacts only with IgMRecognizes determinants specific for  heavy chains (isotypes)Immunoglobulin Isotypes??????Immunoglobulin IsotypesImmunoglobulin IsotypesOccurrence Importance Ig levels B cell tumors Immunodeficiencies Definition LocationImmunoglobulin AllotypesImmunoglobulin Allotypes Definition - Antigenic determinants specified by allelic forms of the Ig genes Location Occurrence Source of anti-allotypic AbsHuman Immunoglobulin AllotypesHuman Immunoglobulin Allotypes Nomenclature G1m(3) Km(1)Human Immunoglobulin AllotypesHuman Immunoglobulin Allotypes Genetics (alleles) Co-dominant autosomal genesKm(1)/Km(3) X Km(1)/Km(1)Km(1)/Km(1) and Km(1)/Km(3) Allelic exclusionHuman Immunoglobulin AllotypesHuman Immunoglobulin AllotypesGenetics (pseudoalleles) Co-dominantG1m(17)G1m(1)214355-358Immunoglobulin AllotypesImmunoglobulin AllotypesDefinition Location Occurrence Importance Monitoring bone marrow grafts Forensic medicine Paternity testingImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition - Unique antigenic determinants present on individual antibody molecules or on molecules of identical specificitynullDNP-BSAStrain A MouseAnti-DNP Ab Purified anti-DNP AbStrain A Mouse Ab against combining site of anti-DNP Ab?? Immunoglobulin IdiotypesAntigenic determinants created by the HVR = IdiotypesImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition LocationIgG1 (kappa) Person 1 anti-BIgG1 (kappa) Person 1 anti-AImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition Location Importance V region marker Regulation of immune responsesnullAgIdanti-Id+-anti-anti-Id+-Regulation by Id/anti-IdImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition Location Importance V region marker Regulation of immune responses VaccinesnullAnti-Idiotype VaccinesImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition Location Importance V region marker Regulation of immune responses Vaccines Treatment of B cell tumors (T cell)