P450 药物相互作用表

P450 Drug Interaction Table http://medicine.iupui.edu/clinpharm/DDIs/table.aspx SUBSTRATES 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4,5,7 amitriptyline caffeine2 clomipramine clozapine cyclobenzaprine estradiol fluvoxamine haloperidol imipramine N-DeMe mexiletine naproxen olanzapine ondansetron phenacetin1→ acetaminophen→NAPQI propranolol riluzole ropivacaine tacrine2 theophylline2 tizanidine verapamil (R)warfarin zileuton zolmitriptan bupropion1 cyclophosphamide efavirenz1 ifosphamide methadone sorafenib amodiaquine2 cerivastatin paclitaxel repaglinide sorafenib torsemide NSAIDs: diclofenac1 ibuprofen lornoxicam meloxicam S-naproxen→Nor piroxicam suprofen Oral Hypoglycemic Agents: tolbutamide1 glipizide Angiotensin II Blockers: losartan irbesartan Sulfonylureas: glyburide glibenclamide glipizide glimepiride tolbutamide amitriptyline celecoxib fluoxetine fluvastatin glyburide nateglinide phenytoin-4-OH2 rosiglitazone tamoxifen torsemide S-warfarin1 PPIs: lansoprazole omeprazole2 pantoprazole rabeprazole Anti-epileptics: diazepam→Nor phenytoin(O) S-mephenytoin1 phenobarbitone amitriptyline carisoprodol citalopram chloramphenicol clomipramine clopidogrel cyclophosphamide hexobarbital imipramine N-DeME indomethacin R-mephobarbital moclobemide nelfinavir nilutamide primidone progesterone proguanil propranolol teniposide R-warfarin→8-OH tamoxifen: TAMOXIFEN GUIDE Beta Blockers: carvedilol S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine fluoxetine imipramine paroxetine venlafaxine Antipsychotics: haloperidol perphenazine risperidone→9-OH thioridazine zuclopenthixol alprenolol amphetamine aripiprazole atomoxetine bufuralol1 chlorpheniramine chlorpromazine clonidine codeine (→O-desMe) debrisoquine2 dexfenfluramine dextromethorphan1 donepezil duloxetine encainide flecainide fluvoxamine lidocaine metoclopramide methoxyamphetamine mexiletine minaprine nebivolol nortriptyline ondansetron oxycodone perhexiline phenacetin phenformin promethazine propranolol sparteine tramadol Anesthetics: enflurane halothane isoflurane methoxyflurane sevoflurane acetaminophen→NAPQI aniline2 benzene chlorzoxazone1 ethanol N,N-dimethylformamide theophylline→8-OH Macrolide antibiotics: clarithromycin erythromycin2 (not 3A5) NOT azithromycin telithromycin Anti-arrhythmics: quinidine→3-OH (not 3A5) Benzodiazepines: alprazolam diazepam→3OH midazolam1 triazolam2 Immune Modulators: cyclosporine tacrolimus (FK506) HIV Antivirals: indinavir nelfinavir ritonavir saquinavir Prokinetic: cisapride Antihistamines: astemizole chlorpheniramine terfenadine2 Calcium Channel Blockers: amlodipine diltiazem felodipine lercanidipine nifedipine2 nisoldipine nitrendipine verapamil HMG CoA Reductase Inhibitors: atorvastatin cerivastatin lovastatin NOT pravastatin NOT rosuvastatin simvastatin Steroid 6beta-OH: estradiol hydrocortisone progesterone testosterone1 Miscellaneous: alfentanil aprepitant aripiprazole boceprevir buspirone cafergot caffeine→TMU cilostazol cocaine codeine-N-demethylation dapsone dexamethasone dextromethorphan2 docetaxel domperidone eplerenone fentanyl finasteride gleevec haloperidol irinotecan LAAM lidocaine methadone nateglinide ondansetron pimozide propranolol quetiapine quinine risperidone salmeterol sildenafil sirolimus sorafenib sunitinib tamoxifen taxol telaprevir terfenadine torisel trazodone vincristine zaleplon ziprasidone zolpidem INHIBITORS Inhibitors compete with other drugs for a particular enzyme thus affecting the optimal level of metabolism of the substrate drug which in many cases affect the individual's response to that particular medication, e.g. making it ineffective. A Strong inhibitor is one that causes a > 5-fold increase in the plasma AUC values or more than 80% decrease in clearance. A Moderate inhibitor is one that causes a > 2-fold increase in the plasma AUC values or 50-80% decrease in clearance. A Weak inhibitor is one that causes a > 1.25-fold but < 2-fold increase in the plasma AUC values or 20-50% decrease in clearance. All other inhibitors. FDA preferred1 and acceptable2 inhibitors for in vitro experiments.* 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4,5,7 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/1A2references.aspx" \l "fluvoxamineInh" fluvoxamine HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/1A2references.aspx" \l "ciprofloxacinInh" ciprofloxacin HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/1A2references.aspx" \l "cimetidineInh" cimetidine amiodarone fluoroquinolones furafylline1 interferon methoxsalen mibefradil ticlopidine thiotepa ticlopidine2 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2C8references.aspx" \l "gemfibrozilInh" gemfibrozil2 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2C8references.aspx" \l "trimethoprimInh" trimethoprim2 glitazones montelukast1 quercetin1 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2C9references.aspx" \l "fluconazoleInh" fluconazole2 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2C9references.aspx" \l "amiodaroneInh" amiodarone fenofibrate fluvastatin fluvoxamine2 isoniazid lovastatin phenylbutazone probenicid sertraline sulfamethoxazole sulfaphenazole1 teniposide voriconazole zafirlukast PPIs: lansoprazole omeprazole2 pantoprazole rabeprazole chloramphenicol cimetidine felbamate fluoxetine fluvoxamine indomethacin ketoconazole modafinil oxcarbazepine probenicid ticlopidine2 topiramate HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "bupropionInh" bupropion HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "cinacalcetInh" cinacalcet HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "fluoxetineInh" fluoxetine HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "paroxetineInh" paroxetine HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "quinidineInh" quinidine1 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "duloxetineInh" duloxetine HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "sertralineInh" sertraline HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "terbinafineInh" terbinafine HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "amiodaroneInh" amiodarone HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/2D6references.aspx" \l "cimetidineInh" cimetidine celecoxib chlorpheniramine chlorpromazine citalopram clemastine clomipramine cocaine diphenhydramine doxepin doxorubicin escitalopram halofantrine histamine H1 receptor antagonists hydroxyzine levomepromazine methadone metoclopramide mibefradil midodrine moclobemide perphenazine ranitidine reduced-haloperidol ritonavir ticlopidine tripelennamine diethyl-dithiocarbamate2 disulfiram HIV Antivirals: HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "indinavirInh" indinavir HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "nelfinavirInh" nelfinavir HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "ritonavirInh" ritonavir HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "clarithromycinInh" clarithromycin HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "itraconazoleInh" itraconazole1 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "ketoconazoleInh" ketoconazole1 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "nefazodoneInh" nefazodone HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "saquinavirInh" saquinavir HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "telithromycinInh" telithromycin HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "aprepitantInh" aprepitant HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "erythromycinInh" erythromycin HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "fluconazoleInh" fluconazole HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "grapefruitInh" grapefruit juice HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "verapamilInh" verapamil2 HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "diltiazemInh" diltiazem HYPERLINK "http://medicine.iupui.edu/clinpharm/DDIs/3A457references.aspx" \l "cimetidineInh" cimetidine amiodarone NOT azithromycin chloramphenicol boceprevir ciprofloxacin delaviridine diethyl-dithiocarbamate fluvoxamine gestodene imatinib mibefradil mifepristone norfloxacin norfluoxetine starfruit telaprevir voriconazole INDUCERS 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4,5,7 broccoli brussel sprouts char-grilled meat insulin methylcholanthrene1 modafinil nafcillin beta-naphthoflavone1 omeprazole1 tobacco phenobarbital phenytoin rifampin rifampin1 rifampin secobarbital carbamazepine norethindrone NOT pentobarbital prednisone rifampicin1 dexamethasone rifampin ethanol isoniazid HIV Antivirals: efavirenz nevirapine barbiturates carbamazepine glucocorticoids modafinil oxcarbazepine phenobarbital2 phenytoin2 pioglitazone rifabutin rifampin1 St. John's wort troglitazone1