文献6.1羟乙基淀粉扩容液临床研究进展

(????) ，20() 3，38 (5) :354?357. ULUBELENA，OKS UZ S，KOLA K?，et al Antibac te ri al dite rP e- ne，fro m the ro ots of sa?ia “?di、[ J〕. ?lanta ??e?，2??)，66 ( 5 ) :4584 62. TEZUKA Y，KASIMU R，BASNET P，et al Aldose re ducta se in- hibito?constituents of the root of sa??miltiorh? Bunge?J」 C??mPh ann B?1( TOk?) ，1997，45(8 ) :1306 ?1311. CHAO K P，HUA K F，HSU H Y，e‘al. Anti?infl ammato?ac tivi- ty of s?101，a dite?ene isolat ed fro m Caloc ed? fo rmo sana bark [J〕. ?2??a Me d，20() 5，71(4) :3(X) ?305. [50〕 wANGD，GIRARDTs，KAsTE NT p，e￡al?Inhibito?actiVity of unsaturat ed fat ty acids and anacard ic ac ids t?ard soluble tissue fa cto?fa ctor Vlla Complex?J ] . J Na t Pro d，1995，61( 11) :1352- 1355 . (???? :200 6?)6?5) 47 48 ?49? 羚乙基淀粉扩容液临床研究进彝 ??，，2，???‘(l . ???????????，??1000 83 ;2. ?????????????????，??1000 83 ) ??:?? ??????????????????????????。??????????，?????????? ??????????????????。?????????????，???????????????????? ???。?????????????????????，???????????。?? ???????????? ????????。?? ??????????????? HES2 0O/0 . 5 ????????????????。??? ??，??????????? HES13 0/ 0.4?????、?????????????????，?????????? ???。?? ???????????????????。???????????????，HES2 00/ 0.5 ??? HES130/0 . 4 ???????????????????，???????、????????????????????? ?，????????????????。 ???:??????;?????;????;HEsZoo /0 .5;HEsl3 0/0 .4 ?????:R6 54 ?????:A ????:100 1?24 94(200 7) 09 - 。?6?04 ???????????????致??、??、?? ???????、????????????，????? ??、????、????????????致???。? ????????????????(MODS) ，????? ????，???????????，????????? ??????????????，??????????? ????。??????????，?????????? ??????????，?????????????，? ?????????????，???????????? ????????;????????????????? ???????????。 ??????????????????????。 ??????????????????????。?? ????????，???????????????、? ????????。???，????????????? ???????????，?????????，???? ????????。????，???????????? ???:①???????????，??????;②?? ?????，????????;③?????，????? ????????????????????，????? ???????，???????????????;④? ?????，?????;⑤???、????，????? ?????。?????????????，?????? ??????????30 ????，??????。?? ?????????????????。 1 ??????? ?????( hydro xyethyl star ch，HES)??????? ???????????????。???????，?? ????? a???????????????，????? ???????????，????????，????? ???????????。????????????? ???????????????(????) 、????? ???????CZ??C6???????????(CZ/ C6 ??)???。??????????????;???? ???????????;?CZ/ C。?????????? ?????。????????????????，??? ??，CZ/ c。????，????????????，??? ???。????，???????????，????? ???????????[’?〕。???????????? ??????，???????、??????CZ/C 6??? ???????????????????????，?? ????????????????????????? ?????。?????????????????、?? ????????(450 /0 . 7)，??????????，?? ????:??，?，????? Te l:(0 10)62017 69 1?73 E?mai l :shinl 9821102 @hot mai l com ?64 6 ? Ch in ?ann J，Zoo 7 ?ray ，Vo l. 42 No . 9 ??????200 7 ?5 ??42 ??9 ? ???????24 h，?5%????????????，? ?????????????????????????。 ?????????????706 ?????????? ??。?????????????( SF DA)???《?? ??????》??????706 ??????????? ??????，?????????????。????? ????????????????、????HESZ??/ 0. 5( ??????)????、???????????? ?????????〔’〕。2(x????????????? ?????? ?? ( HES130 /0 ，4) ??? HESZ oo /0 . 5 ? ????????，????????????????? ???、???????????(CZ/ c6)???，???? ?????????????????。 2 ???? ??????????????????????? ???????????，?????????。???? ???????????，?????????????? ??至????。????????????????? ????????、?????。??，???????? ??、?????????HES2 00/ 0. 5 ???????? ????，???????????????。????? ????????HES130/0 .4 ???????????、 ?????????????????????????， ??????????????????? 2. 1 ???????????????? HESZ(X) /0 . 5 HESZ(X) /0. 5 ??????????200 (X?，???? ?????0. 5。??????????，??????? ????????????????，????????? ????????????????????;????? ????????????????，???????? ?;????????????????，??????。 Boldt?[6]?Dehn。?[，〕?????????，HES200/0.5 ?????????????，???????????? ??。??，??HESZ oo/。. 5?????????，??? ?????????????????。??????， HEsZ oo /0 .5??????????。??????，?? ??????HES200 /0 . 5??，??????????? ??????，?????????至MODS???。Yeh ?{?」?????，HEsZoo /。.5???????????? ????????????????????。Wis - se lin ??????????????、chi an g〔’“1????? ?????????????HES 20 0/ o. 5 ?????? ??????。??Al hson ?〔???????????? HEsZ oo /0 .5????，????，?24 h ??????， HESZoo /0 . 5??????????????????。? ????????，HES20() /0 . 5 ??????????? ??????〔‘2〕。??，?HEsZoo /0 .5???????? ???????。 ?????????、????????????， HESZ oo /0 . 5 ?????????????????，?? ????????????????????????? ?，????????????????????、??? ?????????????????????????， ????????〔’〕。??HEs2 0o/0 ，5???、???? ????????????????????????，? ??????????????????。 2. 2 ????????? HES130/ 0. 4 HES1 30/0 . 4?200 0 ?????????????? ???，??HES2 00/0 . 5?????????，????? ?HESZ oo /0.5???????，?????????，?? ??????????????????;??????? HEsZ oo /0 ?5?????，????????????，?? ??????????????。HEsl3 0/0 . 4 ????? ?????????????，???????????? ????????????。 HES1 3O/0 .4 ??? ? ? ? ? ? ? ? 130 00() ，? HEs2 00/ 0 5????????????????，??? ???????????????????????，?? ????????????????????????? ??。??????0. 5???0. 4(???20 %)，??? ?(CZ/ C‘)?5，1???9，1，???????????? ?，???????????????。???????? ???HEsl 3o/ 0.4????????????????? ??，?“??????”???????。 ???????????????，HES 13 o/0 .4 ?? ??????????，??????????????? ?????。??????，?HES13 0?.4 ?????? ???????????????????;??HEs2 00/ 0. 5??，HES13 0/0 . 4 ??????????????，? ?????。HEsl 30/ 0. 4 ??????6 h ?????? ??，??????4 ?6 h，?100 %?????4 h，?? 70 %???????6 h，?????至????HESZ oo / 0.5[6〕。 ????????，?????HES13 O/0 .4 ???? ?????????。???????????????， ?????????HES2 00/ 0‘5 ????????，?? ????????。 ????????，HES13 0/0 .4 ????????? ??，?????????????????????，? ????????????????????????? ???，?????????????，???????? ????????????????????????? ????????????。El lge r?〔‘3〕??????? ????????????，????，??HEs130 /0 .4 50 mL ?kg?’?3o mL?kg?’HESZoo /0，5?Zo mL?kg?‘?? ??，???????。Jun ghe inric h?’4]???????，? ??????2(X) 7?5??42 ??9? Ch in Pha nn J，2(X) 7 ?ray ，??. 42 No ‘9 HES200/ 0. 5 ??，???????HES130 /0 . 4 ?，??? ?????????vw ????????????(?? s h)。Hal sc h[ ‘，」?????，???????????? HES 13 0/0 . 4至???1 ???，???????????。 woessner?〔‘6]?????????HEsl3o/0.4???? ??????????????????????，??? ?，??????，HES13 0/0 . 4 ????????，??? ?????????????，???????????， ???????，??、???????????????。 ????????，HES13 1】/ 0.4 ????????? ?。?51 30/0. 4???10 d??? 1????????， ???????( < 1%) ，?????????。Bo ldt ??”〕??????????????????????? ???，????，HES130 /0 . 4 ???????。200 2 ? Ju ng he inric h?〔‘?〕????????????????，? 19 ???????????????????????，? ???，??????，????????????，??? ????HES 13() /0 . 4???????。????HES 130/ 0. 4?HES ?X)/ 0.5????????????????? ?，????:?????????????，?HEs130/ 0.4??????????????。Ne ff ?〔‘，]???? ?，?????????????(70 mL?kg?’?d?’)?? HES1 30/ 0. 4，??????????????，????? ???ICu???????。??‘5?r?〔20] ????， ?????????????HES13 0/0 .4，?????? 50 mL ???’，??????????，????HEsZoo / 0.5?????33 ? ?kg?’，???????????? ??????。??，HE S13 0/ 0.4 ?????????? ????????50 ? ???’????????，??? ?????，??????????????????。 ????，HES13 O/0 .4 ????HES20O/0 . 5 ???? ??????????。?????????????? ????[zl 〕，?????????HEsl3 0/0 .4????? ??，?????????( Se la m l ? si cam l) ???，? ?????〔22?。???????，?HEs13o/0 .4??? ?????，???????????，???????? ????，???????????。????????? ??，??????，????????，??????。 HES130/0 .4??????????????。??，?? ?????????、???????????。???? HES1 30/0 . 4 ???????????????，Lo ch bu hl er ??」?????HEsl3 0/0 .4?????????。?? ??，????????、????、?????、???? ???，???????，HES13 0/0 .4 ?????“???” ????????，?????，??????????。 ??，20( ??1?，HES130/ 0.4 ???????????? ?。 3 ????? ?64 8 ? ?Ch in Pha nn J，2(X) 7 Ma ?，??42 No .， ????，??????????????????? ?????;????，?????????，?????? ????，??????、?????????，????? ?致????????????????、????、?? ??、????????????????????，?? ???????????。????????????? ??????????“???”、??????????? ??????，????????????、??????、 ??????????????????，??????， ??????????(?????)????，????至 ????????????〔25) 。1998 ?coc hrane〔??? ?????????????????，???????? ?????????????，????，?????、?? ???????????，????????????? 4%。????????????????，?????? ?????????????????，???????? ????????(?????<30 9?L?’)。????? ????????????，????????????? ????????????????????????? ?????。 ????，?????????????、????? ????，??????????，HES13 0/ 0. 4 ????? ????????????，????????????? ???????????，?????????????? ??????，????????????。????，? ?????????????，???HES13 0/0.4 ??? ?????????，???????????????? ????????，???????????????、? ????????????????????，????? ?????????????????。 RE FERE NCES [1〕 WUz H. Mod emconcept of nuid re plac ement in the surgi cal pa- tients[J」. J Su?Co n‘el ，t Pract (???????) ，2(X) 4，9 (4 ) : 343?? [2〕 BARoNJ r c?stal loi ds vers us colloids in the tre at ment of hypO- vo le mic shock「A]. In: Vinc ent J L，ed l/e。rb oo ?of ln te。? Ca re and E”1??????Me di ci ne [M〕. Berl in: Spri ?er，20?): 443?466. [3] rrREIBJ，HAAss A，plNDURG，et al. All mediumstarc hes are not the ，ame : inll ue nce of th e de?『ee of hyd rox yeth yl subst : tu tion of hyd rory ethyl slarch on plas ma volume，hemo rr heolo g?ic conditions，and coagUlat ion?J〕. Tra l??，1996，36(5) :450?55. [4〕 TREIB J，HAASS A，pINDUR G，et al. 1?uence of the CZ/ C6 h?。?th yl ation ?tio of h?ro?x?thyl sta?h (HES) on hemo- rh eolo?，coa，lat ion and elimination kinetics[ J ] . ?romb H?m- os t，1995，74 (6 ) : 145 2?1456. [5〕 LA xENAIRE MC，CHARpENTIER C，FELDMANL Anaphy- lac to id re ac tions to cOll oid Plasma subst itutes : Inc ids nce，ri sk fac - tors mechanisms. AFre nch multicenter pro spective stu dy[J〕.Ann Fr Anes th Rea nim，1994，13(3 ) : 301?310 [6〕 BoLDT J，?HMANNA，RoMpERT R，et al?Vohi me therapy ?th a ne whydrOxyeth yl sta“?h so lution in cald iac su?ical pat ients befo ?c?io pulmon? b?ass[J] . J Ca rdi oth orac Vas c Anes :h， 201?)，14 (3) : 264 ?68. [7 ] DEHNE MG，MUHll NG J，SABLOTZKI A，。t al. H?ro xvethyl ??????200 7?5 ??42 ??9 ? [8〕 〔9」 ， . . . ， I J 0 11 ? . ? 1 ? . l r es L 1 . J ﹄es es .J 2 3 ? ? ?1 r . . J L es L [141 on re nal fu nc ti on in elder?ly pat ients und erso ing c? iac sur??: c0mpari son of a newst arc h pre parat ion wi th ?lati n[ J〕. Int e。? Ca re ?d，20() 3，29 (5) : 763?69. [18」 JUNGHEINRICH c，SCHARF R，WARGE?u M，et ?. ?e Pharm ac okineti cs and tOl erability of an intrav eno us i1if[ lsion of the ne wh?ro?etllyl starc h l30/0 . 4 (6%5(X) mL) in mild?to sev e， rena l impai rment [J〕. Anes th Ana lg ，2(X) 2，95: 544?51. 〔19」 NEFFT A，JUNGHEINRICH C，DOELB ERGM，?al . Adva nta - ?s of 6% hydroxyeth yl starch l30/0 ，4 ( VO luven ) at re petiti ve high dOse levels in pat ient s with se vere cra nioc ere bral tra uma【J〕. C?ica l Ca re ，2(X) 1，5( 11) : 114?116， [20 j KA SPE RSM，MEINERT P，KA MPE S，et al . Lar ge?dos e hydroxy- ethyl st?h l30/ 0 4 dos e not in?creas e bll?xl loss an d tr?lsfu si on req uire me nt s in coro l?? art e? b?as s stlrge? compare d ?th hydro?eth yl st ?h Z(X) / 0. s at rec omm ended dose?J〕. A?th， 2(X] 3，99 : 42 ?7. [21] PE NG C H，WUWx Di?0515，tre at ment an d ?ve nt ion of SIRS caused by bili? surs e?eme rse ncy[ J ] . Ch in j prQctic? Su?(????????)，200 3，23(6) : 329?331 [22 」 LA NGK，stJTrNERS，BoLDTJ，et al，Volume re placeme nt ?th HES130/ 0. 4 m? ?uce the i?amOlatOry re spon se in pat ient s under ，1?maj or ab dominal surge??J〕. Ca n J Anaes th ，2(X) 3，50 (10) : l0( ??1016. ?23 」 BOLDTJ，nUCKEM，KuMLE B，。t al. 1?uence。f diffe o nt vol - ume ，Pl ac ement st rategi es on il?ammat ion and endothelial ac ti - va Uoo in the elderly unde?1ogmaJ or ab do?nal surse ?[J〕. In - [24 ] 〔15」 ﹁ ? ? ︺ ﹁ ? ? ﹂ 5 6 2 2 ? 1 ? ? I L [1‘] 〔17 ] st?h ( HES) doe s no t dire ctly affe ct re nal fu nction in pat ients ?th no pri or re nal impai rme nt[ J〕. J Cl in A?th，200 1，13(2) : 103?111. YEH T J，PARMAR J M，REBEYKA I M，et aL Umiting edema in neonat al cald io pulmon ? by pas s with narro wra n?mol ecular we igh t h??xyethyl st?h[ J〕. J Th orac Ca rd?J?“c s“?，1992， 104 (3 ) : 659.665. ?q?EUNKW，PAIu l?10S P，PANEI，rA T F，et ? M?lum ? Iec u」ar we ight ?ntas ta?h ?uces re?rfl lsion inj ury ?da〕~ ing C?111? ??in ? n??】el of sni ? c? isc h?a?J〕. J ?zas ‘ 5??，1?8，27 (1) : 1??116. CH?NG C H，WU C P，PE RNG W C，et al. Dex amethas one an d pentas ? h pmduce additive attenuat ion Of ischae mia / re perfu sion lung inj ury?J〕. CI ‘n sc i，2?x，〕，99(5) : 413?419. ALIJSON K P，GOSll NG P，JONES S，et al Rando?ze d tri al of hydrOx，eth yl starc h vers u，?lati ne for tra uma re suscit at ion[J ] . J ?“uma ，1999，47(6) : 1114?1121. FE ??RA J J，DYE? D L，COU[J NS J N，et aL E??ts of pe n- t??tloll ad l?ni ?ation on ?crDvasc ular ?m??ility al terat ions in - duc??????eryr ?inj ?〔J] .&?，1??，1?(2) :182 ?1? ELLGER B，FRE Yll0FF J??OGTM，?al. High dose vol ume re- Plac ement using HES130/0 . 4 duri ng maj or su rge I’y doe s not alt er co??lat ion [J〕.??J An?t?，2(X) 2，19 (24) : 77. JUNGHEINRI CH C. Vol ume effi caCy and ?duced infl uence on me asu res of cOS?lati on usi?hyd?xyeth yl starc h l30/D. 4 (6%) with an ?timised in vivom01ecular we igh t in o?opae?dic su ?r- y: a ran do?zed ，dou ble?lind study〔J] .Dr???R&D，2??，5 ( 1) : 1? HAISCH G. Th e infl uence Of intra vas cular volume theraPy with a new hydro?yeth y18ta?h pre par at.on (6% HES130/0.4) on coag- ulation in p?ents under?oing maj or ab do minal su rg?ery 〔J] . A?th A?19 ，200 1，92 (3) : 565 ?71 . WOESSNER R. Innuence of a fo ng.ten?，high ?do se vol ume th era - ??th 6% ?ydro xyethyl st??h l3o/ 0. 4 or c?talloi d solu ti on on bem?yn?ni cs，?eOl ogy an d homeo st a8i s in Pat ients wi th ac ute isc he ?c st ro ke : Re ?hs of a ra l?。m?ed ，P?ebo?co nt ?le d， double?in d st u?〔?????hrs ? ??emos t ?。?，2(X) 3，33 (3) : 121?126. BOLDT J. 11』uenc e Of tw o diffe re nt vo1ume re placement re gi mens LO CHB?H?RH，GAU[J C，HAGE MANNH. H?rOxyeth yl st o h HE Sl 3( )/ D. 4 in pa?1?。su ??ry : re sul ts of an explorat ive ，con - tro lled ，mullicentre s?re ty stu dy〔J〕. C???。I ca re ，2003，7 (2) : 107 ?111. B0LDT J. Human a1bumin on the intensive care unit : Can we li ve wi?。ut it[A]. In: Vinc ent J L，ed. }?。?ookof ??ens i，ca、 and En????.??d??，〔M」. Berlin: ?ri nger ，2??: 467?47 5. COCHRANE INJ URI ES GR0 UP ALBUMIN REVIEWERS. Htl- man al bu min ad mini，tyation in cri tically ill pat ients : ?stemat ic review of ran domized controlled tri ?，[J] ?r ???，1995，317 (7153 ) :235，240. (????:200 6?2?8) 脂质体作为免疫佐剂的应用进展 ???，??’，??? (?????????，??1100 16) ??:?? ????????????????。?? ?????????????????????????，?? ???、??。?? ???????????、DNA??????，???????????。?? ????????、 DNA????????????，????????????????????????。 ???:???;????;????;DNA??;???? ?????:R94 ?????:A ????:100 1?24 94 (200 7)09 ?。?9 ?。 ???????????，???????????? ??、??????????????????????? ??????，?????????，????????? ?。?????????、?????????????? ????DNA??。???????????????? ????????????????????????? ?，???????????????，???????? ?。???????????????????、DNA?? ????:???，?，????? ’????:??，?，???，????? TeFFax :(。24)23986349 E?ma il :rls nowele @126 . com ?????? ????.??? ???????，????，????‘649 ‘