肺心病、肺性脑病机制

nullnullnull Alteration of circulatory system(Pulmonal heart disease) Cor pulmonale(肺心病) Pulmonary hypertension Myocardial dysfunctionPulmonary hypertension Myocardial dysfunctionPulmonal heart disease (1)Pulmonary hypertension : (1)Pulmonary hypertension : PaO2↓，pH↓→ pulmonary vascular contraction; Blood viscosity ↑; Damage of pulmonary vasculature → Increased right ventricular afterloadThicking of pulmonary vascular wall; （2）Myocardial dysfunction: （2）Myocardial dysfunction: ischemia; acidosis; electrolytes disturbances...*acidosis,hypoxia→cerebral vessels *acidosis,hypoxia→cerebral vessels *acidosis,hypoxia→cerebral cellsPulmonary encephalopathy:Acidosis,Hypoxia →cerebral vessels Acidosis,Hypoxia →cerebral vessels * Expansion of cerebral vessels→Hypoxia ↑ （vicious cycle）*DIC→brain edema, intracranial pressure ↑*Vasogenic brain edema(血管源性脑水肿) *Cytotoxic edema(细胞毒性脑水肿)Acidosis,Hypoxia → cerebral cellsAcidosis,Hypoxia → cerebral cellsAcidosis,Hypoxia Acidosis,Hypoxia pH↓(in CSF) →acidosis in cerebral cells↑→ nullAcidosis