药学英语 标准试卷2

一、填空(每1分,共20分)。 1 乙烷 2 甲醇 3 溴 4 汞 5 精氨酸 6 赖氨酸 7 酮8 乙酸乙酯 9 氢氧化钠10 碳酸钾 11 Benzene 12 Heptane 13 Hydrogen 14 Oxygen 15 Threonine 16 Cysteine 17 Phenol 18 Ether 19 Calcium carbonate 20 Toluene 答案: 1 Ethane 2 Methanol 3 Bromine 4 Mercury 5 Arginine 6 Lysine 7 Acetone 8 Ethyl acetate 9 Sodium hydroxide 10 Potassium carbonate 11 苯12 庚烷 13 氢14 氧 15 苏氨酸16 半胱氨酸 17 酚18 醚 19 CaCO3 20 甲苯 二、写出下列缩写英文全名并翻译(每题2分,共10分)。 1 FDA: 2 ICH: 3 GMP: 4 HPLC: 5 DMSO: 答案: 1 Food and Drug Administration (美国)联邦食品及药物管理局 试卷(A)共( 6 )页第( 1 )页 2 International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use 人用药品注册技术要求国际协调会 3 Good Manufacturing Practice 药品生产和质量管理规范 4 High Performance (Pressure) Liquid Chromatography 高效液相色谱 5 dimethyl sulfoxide 二甲基亚砜 三、选择填空(每题2分,共14分)。 1 C is probably the most widespread quality system followed across the pharmaceutical industry as a whole. A GAP B GCP C GMP D GLP 2 Drug design aims to improve the A of the lead compound and to remove the undesirable effects. A desirable effects B toxic effects C adverse reaction D first-pass effect 3 D have amino group. A Aldehydes B Carboxylic C Alcohols D Amines 4 By being C of these pharmacologic principles, and by remaining vigilant to countless interaction between drug and ailing body, one can substantially reduce the side effects of numerous drugs. A cognizant B vigilant C view D catabolize 5 Generally, A is more water soluble than the free acid or free base. A the ionizable salt of the drug B the ester of the drug C the coupling of the drug D the free drug 6 In identifying a plant constituent, once it has been isolated and purified, it is necessary first to ___________and then to___________. 试卷(A)共( 6 )页第( 2 )页 A determine the class of compound B find out which particular substance it is within that class 7 There have been several examples where the natural agonist for a receptor was used as the lead compound in order to design a receptor A . A target B structure C bioactivation D antagonist 答案 1 C 2 A 3 D 4 C 5 A 6 7 A 四、判断,并用×√示(每题2分,共16分)。 1 ()Analysis chemistry is concerned with the chemical characterization of matter and the answer to two important questions: what is it and where is it. 2 ()The discipline of analytical chemistry consists of selective analysis and specific analysis. 3 ()the level of biological activity may not be particular high, but that dose matter. 4 ()number of atoms, are hydrogen, oxygen, nitrogen, and carbon, which together make up over 98% of the mass of most cells. 5 ()In vivo, the temperature is maintained at a constant 37℃, the agitation of stirring rate is held to a specified constant. 6 ()Biochemical tests may also be invaluable: presence of a glycoside can be confirmed by hydrolysis with β-glucosidase, of a mustard oil glycoside by hydrolysis with myrosinase and so on. 7 ()Troches, tablets which are intended to be chewed, and drug products intended for sustained release or prolonged or repeat action. 8 ()modification and improvement of existing active molecules is a type of search for new lead compound. 答案:1 × 2 × 3 × 4 × 5 √ 6 √7 √8 √ 试卷(A)共( 6 )页第( 3 )页 五、英译汉(每题5分,共20分)。 1 Biochemistry aim to explain biological form and function in chemical terms. 答案:生物化学的目标是在化学方面解释生物的形态和功能。 2 By being cognizant of these pharmacologic principles, and by remaining vigilant to countless interaction between drug and ailing body, one can substantially reduce the side effects of numerous drugs. 答案:只要充分认识并运用这些药理学原理,并对药物和人体之间无数相互作用保持高度警惕,我们就能大大减少许多药物的副作用。 3 Analytical chemistry provides the methods and tools needed for insight into our material world…for answering four basic questions about a material sample: ①What ②Where ③How much ④What arrangement, structure or form? 答案:分析化学为我们洞察物质世界提供了方法和工具来解答关于物质样本的4个基本问题:1.是什么2.来源3.含量有多少4.结构、形式、组成。 4 There are three phases in the analysis: the fast-screening phase, the identification phase and possible quantification. 答案:分析的过程分三个阶段进行:快速筛选阶段,确定阶段,可能的量化阶段。 六、问答题(每题5分,共20)。 1 In order to design a drug product that deliver the active drug in the most bioavailable form, what the pharmacist must consider? 答案:In order to design a drug product that deliver the active drug in the most bioavailable form, the pharmacist must consider (1) the type of drug product (e.g. solution, suspension, suppository) ; (2) the nature of the excipients in the drug 试卷(A)共( 6 )页第( 4 )页 products; (3) the physicochemical properties of the drug molecule. 2 In identifying a plant constituent, once it has been isolated and purified , what is necessary? 答案:First to determine the class of compound and then to find out which particular substance it is within that class . 3 Which four types of successful strategies can lead to new lead compounds? 答案: A retrospective analysis of the ways leading to discovery of new drags suggests that there are four types of successful strategies leading to new lead compounds.The first strategy consists of systematic screening of sets of compounds arbitrarily chosen for their diversity, by selected biological assays.The second strategy is based on the modification and improvement of existing active molecules.The third approach resides in the retroactive exploitation of various pieces of biological information that sometimes results from new discoveries made in biology and medicine and sometimes is just the fruit of more or less serendipitous observations.Finally, the fourth route to new active compounds is a rational design based on the knowledge of the molecular cause of the pathological dysfunction. 4 In vitro dissolution testing, what kinds of factors must be considered? 答案:For one thing, the size and shape of the dissolution vessel may affect the rate and extent of dissolution .A second consideration is the amount of agitation and the nature of the stirrer. The temperature of the dissolution medium must also be controlled and variations in temperature must be avoided. Most dissolution tests are performed at 37℃. The nature of the dissolution medium will also affect the dissolution test. 试卷(A)共( 6 )页第( 5 )页