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肾移植排斥反应中细胞毒性T淋巴细胞相关抗原4的作用

2017-09-16 4页 doc 17KB 21阅读

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肾移植排斥反应中细胞毒性T淋巴细胞相关抗原4的作用肾移植排斥反应中细胞毒性T淋巴细胞相关抗原4的作用 122233222陈昌庆,石炳毅,蔡 明,赵豫波,金伯泉,王春艳,韩 永,肖 漓,周文强, 2李州利 1 23解放军医学院,北京市 100853;解放军第309医院全军器官移植研究所,北京市 100091;解放军第四军医大学免疫教研室,陕西省西安市 710032 Cytotoxic T lymphocyte-associated antigen 4 in acute rejection after renal transplantation 12223Chen Cha...
肾移植排斥反应中细胞毒性T淋巴细胞相关抗原4的作用
肾移植排斥反应中细胞毒性T淋巴细胞相关抗原4的作用 122233222陈昌庆,石炳毅,蔡 明,赵豫波,金伯泉,王春艳,韩 永,肖 漓,周文强, 2李州利 1 23解放军医学院,北京市 100853;解放军第309医院全军器官移植研究所,北京市 100091;解放军第四军医大学免疫教研室,陕西省西安市 710032 Cytotoxic T lymphocyte-associated antigen 4 in acute rejection after renal transplantation 12223Chen Chang-qing, Shi Bing-yi, Cai Ming, Zhao Yu-bo, Jin Bo-quan, 32222Wang Chun-yan, Han Yong, Xiao Li, Zhou Wen-qiang, Li Zhou-li 12Chinese PLA Medical School, Beijing 100853, China; Organ Transplantation Institute of 3PLA, the 309th Hospital of PLA, Beijing 100091, China;Department of Immunology, the Fourth Military Medical University of PLA, Xi’an 710032, Shaanxi Province, China 背景:细胞毒性淋巴细胞相关抗原是新近发现的共刺激分子,在肿瘤及自身免疫性疾病中研究较多,在肾移植T4 领域缺少研究。 目的:探讨细胞毒性淋巴细胞相关抗原在肾移植排斥反应中的作用。T4 :纳入肾移植患者例,根据移植后肾功能分为组,急性排斥组例,移植肾功能稳定组例。同时5022030选择例健康查体者作为健康对照组。分别抽取外周静脉血,采用法及流式细胞术检测观察对象血清及30ELISA 外周血淋巴细胞中的细胞毒性淋巴细胞相关抗原水平。T4 结果与结论:细胞毒性淋巴细胞相关抗原在肾移植后急性排斥组、肾功能稳定组及健康对照组血清中的表达水T4 平差异有显著性意义,。肾功能稳定组显著低于健康对照组,(F=70.008 1P=0.000 0)(P=0.000 0)急性排斥组显著低于健康对照组,急性排斥组显著低于肾功能稳定组。细胞毒性(P=0.000 0)(P=0.000 0)淋巴细胞相关抗原在肾移植后急性排斥组、肾功能稳定组及健康对照组淋巴细胞中的表达水平差异无显著性意T4 义,。提示细胞毒性淋巴细胞相关抗原在肾移植患者发生排斥反应时血清中(F=1.865 6P=0.161 7)T4 表达减低,具有一定的相关性,可能参与了排斥反应的发生。 中国组织研究杂志出版内容重点:肾移植;肝移植;移植;心脏移植;组织移植;皮肤移植;皮瓣移植;血管移 植;器官移植;组织工程 全文链接: 关键词:实验动物;组织构建;肾移植;细胞毒性淋巴细胞相关抗原;急性排斥反应;尿毒症;共刺激 T4 分子;免疫抑制剂; :Abstract BACKGROUND: Cytotoxic T lymphocyte-associated antigen 4 is a newly discovered costimulatory molecule. It has been studied more in tumor and autoimmune diseases, less in the field of kidney transplantation. OBJECTIVE: To explore the role of cytotoxic T lymphocyte-associated antigen 4 in acute rejection after renal transplantation. METHODS: Fifty patients undergoing renal transplantation were divided into acute rejection group (20 cases) and stable graft function group (30 cases). Another 30 healthy persons served as control group. Blood samples were extracted from the peripheral blood. Cytotoxic T lymphocyte-associated antigen 4 was detected by enzyme linked immunosorbent assay and flow cytometry. RESULTS AND CONCLUSION: The expression of cytotoxic T lymphocyte-associated antigen 4 in the serum showed significant differences in the acute rejection group, stable graft function group and healthy control group (F=70.008 1, P=0.000 0), but showed no difference in peripheral blood lymphocytes of three groups (F=1.865 6, P=0.161 7). Compared with the healthy control group, the expression levels of cytotoxic T lymphocyte-associated antigen 4 in peripheral blood lymphocytes of acute rejection group and stable graft function group were significantly decreased (P=0.000 0). In addition, the acute rejection group had a lower cytotoxic T lymphocyte-associated antigen 4 expression than the stable graft function group (P=0.000 0). In renal transplant rejection, the expression of cytotoxic T lymphocyte-associated antigen 4 in serum was reduced, showing some correlation with acute rejection after renal transplnatation. Cytotoxic T lymphocyte-associated antigen 4 might be involved in the rejection. 中国组织工程研究杂志出版内容重点:肾移植;肝移植;移植;心脏移植;组织移植;皮肤移植;皮瓣移植;血管移 植;器官移植;组织工程 全文链接: :Key words transplantation; kidney transplantation; graft rejection; uremia; immunosuppressive agents; flow cytometry; 中图分类号: R318 基金资助国家科技支撑计划: (2008BAI60B04) 通讯作者李州利,主任医师,硕士生导师,解放军第医院全军器官移植研究所泌尿一科,北京市: 309 100091 作者简介陈昌庆,男,年生,安徽省安庆市人,汉族,解放军医学院在读硕士,主要从事器官移植与移植免疫研究。: 1988
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