四环素类抗生素

四环素类抗生素 tetracyclines antibiotics 四环素类抗生素是由放线菌产生的一类口服广谱抗生素，包括 四环素、金霉素、土霉素及半合成四环素类。四环素类曾广泛应 用于临床，由于常见病原菌对本类药物耐药性普遍升高及其不良 反应多见。1950年从土壤培养液中分离出土霉素 • 化学名:6-甲基-4-(二甲氨基)-3，5，6，10，12，12a- 六羟基-1，11-二氧代-1，4，4a，5，5a，6，11，12a- 八氢-2-并四苯甲酰胺 • 拼音名:TUMEISU • 英文名:OXYTETRACYCLINE DIHYDRATE CAS No.:6153-64-6 • 分子式:C22H24N2O9 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities • 土霉素片分子量:460.44 • 规格:?0.125g?0.25g • 作用类别抗感染类药物 • • 适应症 • 1(该品作为选用药物可用于下列疾病: ?立克次体 病，包括流行性斑疹伤寒、地方性斑疹伤寒、洛矶山热、 恙虫病和Q热。 ?支原体属感染。 ?衣原体属 感染，包括鹦鹉热、性病、淋巴肉牙肿、非特异性尿道炎、 输卵管炎、宫颈炎及沙眼。 ?回归热。 ?布鲁 菌病。 ?霍乱。 ?兔热病。 ?鼠疫。 ? 软下疳。治疗布鲁菌病和鼠疫时需与氨基糖苷类联合应 用。 • 2(由于目前常见致病菌对该品耐药现象严重，仅在病原 菌对该品敏感时，方可作为选用药物。 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities 药代动力学 该品口服后的生物利用度仅30%左右。单剂口服该品1小时后，2 小时到达血药峰浓度(Cmax)，为2.5mg/L。该品吸收后广泛分布于肝、肾、肺等组织和体液，易渗入胸水、腹水，不易透过血-脑脊液屏障。该品蛋白结合率约为20%。肾功能正常者血消除半衰期(t1/2)为9.6小时。该品主要自肾小球滤过排出，给药后96小时内排出给药量的70%，其不吸收部分以原形药随粪便排泄。 药理毒理 该品为广谱抑菌剂，许多立克次体属、支原体属、衣原体属、螺旋体对该品敏感。肠球菌属对其耐药。其他如放线菌属、炭疽杆菌、单核细胞增多性李斯特菌、梭状芽孢杆菌、奴卡菌属、弧菌、布鲁菌属、弯曲杆菌、耶尔森菌等对该品亦较敏感。多年来由于土霉素和四环素类的广泛应用，临床常见病原菌对土霉素素耐药现象严重，包括葡萄球菌等革兰阳性菌及多数革兰阴性杆菌。该品与四环素类抗生素的不同品种之间存在交叉耐药。该品作用机制为药物能特异性与细菌核糖体30S亚基的A位置结合，抑制肽链的增长和影响细菌蛋白质的合成。 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities 用法和用量 口服，成人一日1.5,2g，分3,4次;8岁以上小儿一日30,40mg/kg，分3,4次。8岁以下小儿禁用该品。 不良反应 1消化系统:胃肠道症状如恶心、呕吐、上腹不适、腹胀、腹泻，偶有胰腺炎、食管炎和食管溃疡的报道，多发生于服药后立即卧床的患者。 2 肝毒性:通常为脂肪肝变性，妊娠期妇女、原有肾功能损害的患者易发生肝毒性，但肝毒性亦可发生于并无上述情况的患者。 3 过敏反应:多为斑丘疹和红斑，此外可见荨麻疹、血管神经性水肿、过敏性紫癜、心包炎以及系统性红斑狼疮加重，表皮剥脱性皮炎并不常见。偶有过敏性休克和哮喘发生。某些用四环素的患者日晒时有光敏现象。所以，应建议患者不要直接暴露于阳光或紫外线下，一旦皮肤有红斑则立即停药。 4 血液系统:偶可引起溶血性贫血、血小板减少、中性粒细胞减少和嗜酸粒细胞减少。 5 中枢神经系统:偶可致良性颅内压增高，可表现为头痛、呕吐、视神经乳头水肿等。 6 肾毒性:原有显著肾功能损害的患者可能发生氮质血症加重、高磷酸血症和酸中毒。 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities 7 二重感染:长期应用该品可发生耐药金黄色葡萄球菌、革兰阴性杆菌和真菌等的消化道、呼吸道和尿路感染，严重者可致败血症。 8 该品可沉积在牙齿和骨骼中，致牙齿产生不同程度的变色黄染、牙釉质发育不良及龋齿，并可致骨骼发育不良。 9 应用该品可使人体内正常菌群减少，导致维生素B缺乏，真菌繁殖，出现口干、咽痛、口角炎和舌炎等。 兽用土霉素 兽用土霉素注射液 通用名称:盐酸土霉素(主要成分) 适 应 症:用于某些革兰氏阳性和隐形细菌、附红细胞体、立克次体、支原体等感染 主治病症: 1、呼吸道病症:呼吸困难、咳嗽、气喘等。如猪喘气病、肺疫、传染性胸膜肺炎等 2、消化道病症:黄、白痢，水肿，流行性腹泻等 3、附红细胞体病、阿米巴原虫病、血孢子虫病、牛边缘边虫病、 泰勒氏焦虫病引起的高烧不退、 皮红、血尿黄疸、贫血等症有良效 4、对感染、气肿疽、放线菌病、钩端螺旋体病等有很好的疗效 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities 兽用盐酸土霉素 • 【含 量】?98% • 【性 状】本品为黄色结晶性粉末，味苦，易溶于水 • 【药理作用】 • ◎对革兰氏阳性菌和阴性菌、立克次体、支原体、衣原 体、螺旋体、放线菌、阿米巴原虫均有抑制作用。抗菌 原理主要是作用于菌体核蛋白体，抑制肽链的形成，使 菌体蛋白质合成障碍，而产生抑菌作用。 • 【适 应 症】 • ◎本产品防治鱼类各种细菌性疾病如:爱德华氏病、链 球菌病、诺卡氏菌病。 • ◎海参因细菌、霉菌、病毒等引起爆发性流行病如化皮 (溃烂)、肿嘴、吐肠、摇头等疾病 • ◎虾的红腿病、烂鳃病、甲壳溃疡病以及蟹的溃烂病、 烂肢病、水肿病均有治疗作用。 • 【适用范围】 • 适用于海参、鱼、虾、蟹类、等水产动物的整个育苗期、 保苗期及养成期。 • 【包装规格】500g/袋×2袋/桶×12桶/箱 • 【贮 藏】密封、遮光、在干燥阴凉处保存 • 【不良反应】未见不良反应 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities