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[18] 5?J???K???????A?????? ?K?????A???????y???F?:?????2?????A?4 ?4?????????A?????????t?????u?A???????? ???K?F?H?????O??????,?F?H?L???K?F???I???? ?A????1ml/300gd(1ml?????A??2g),?????I?? 10d,???X3d,???I30d???????????K?F???t???? ???L?s?J??,?A?????A???/???????u?A???????s ??????,?????????????????A?[?FLH????T ?????:???FFSH?W???L?s?X?? [19] ?????,?j?? ???????u?????)?F?L???t???)?F???q?K????????, ?????????u?)?F???????h???????K???:????,?? ?????????K?F???W?????P???????????????v?3 ???????W?? [20] 6?????k?F?L???2 ?????????p???p?X?B?l?????L???????2?? ?????????k?F???????k?FCaFeZnCuMg??, ?n???????2?p???1?Y?????l???V?????/???2???2 ?-?????:?]?P?????:?????k?F,???????S?P?J?? ???2?????/5???k?F???B???p,?I???????????X ?L?s?? [21] ?O?p?????I???%?j?????I?(,??5???k ?F???B?????1???????0,?????????%?j?L?s?G?? ?F???W????????,?O???L?%?????????,?8???% ?j?????y?????????2?p?????Y?????????? ???T?v???????p???h???,?????2?O???O ???3???1?J?????i?????M,???]?0?/???K?P???< ???????<???I?????????????:?:???????J ???????????????:?v???2?????????????P???? ?????????J?????????????????????2?O?????n ?O???y?J?????i?????M,???????K?P???h?K,???] ?0?/???K?P???<,?v?1?????4?4?n???p?/SOD MDALPO??,?:???????????????O???[?[???? ?p?h???x???O??,?????O?????????s?????? ???????????P?n?????,?????2?????/?:?%?? ????DNA?/???2?p???/???[?????l????????,?(?? ???????????O???????????],?????:?????????O ???????????O???n?(?W???O???],???????2?O ?????A??,???????F?n,???????K?Z?r???????K?W ???O??,?????:?p???????2?O?????????K?1?? ???%???????:???????????????p???????O???? ?4??,?J???????4?4?n?:???????K?????? ???7???c 1??????,?G????,???f,??.?????p?h?????2?????O???? ??[J].?p???h??????,19916(4):43. 2??????,?<???J,?H????,??.???????s?h?v?1???I???? ?-?G?]???????T??????????CRF???????????? ??[J].?p???p???h???,?j??,199717(1):3-9. 3???y,?????J,????,??.?????L?h?v?I???7???2???FT ???????????????O??[J].?p???p???h???,?j ??,1999,19(10):6-10. 4PhelouzatMA,ArbogastA,LaforgeT,etal.Exce ssiveapoptosisofmatureTlymphocytesisach aracteristicfentureofhumanimmunesenescenc e[J].MechAgeingDev,1997,8(8):2-5. 5ggarwals,GuptaS.IncreasedapoptosisofTcellsubsets inaginghumans:alteredexpressionofFas(CD95),FasLi gand,Bcl22,andBaxJ[J].Immunol,1998,23:1-2. 6ThiagarajanG,ChangdaniS,HarinarayanaRaoS,et al.MolecularandCellassessmentofginkgobiloba extractasapossibleophthalmicdrug[J].ExpEye Res,2002,75(4):421-430. 7?????A?D???A.?e?????????n???????2???/???????O ??[J].?p???2?????j??,2001,21(11)454-455. 8???u??,?Y??,????,??.?????n?????]???????????K ?P???/?O??[J].?p?????8???n ??,2001,17(6):628-631. 9??????,???,??,?????.,??.???c???O?u?????i?????? ???????????/[J].?r?????h?K???? ??,2000,21(10):1209. 10TombaughGC,RoweWB,ChowAR,etal.Theta- frequencysynapticpotentiationinCA1invitod istinguishescognitivelyimpairedfromunimpai redagedFischer344rats.Neuro-sci,2002,22(2 2):9932-9940 11???i?????i?I.?????P?????n???????2???)?F?????? ?????????]???????h????????[J].?p?????:?h???? ??2004213136-137. 12?F?,,????,?F?C,??.?????????????S?2???K?K?F?? ?L?]???2???????O??[J].?p???p???h???,?j ??,2000,20(1):43. 13???L?t,?G?b??.?????s?W?????????2?K?F?????????? ???????????]???:?%[J].?p?????8?L?W ??,2002,18(6):32-34. 14BrownJP,WeiW,SedivyJM.Bypassofsenescence afterdisruptionofp21CIPI/WAFIgeneinnorm diploidhumanfibroblasts[J].Science,1997,27 7:831-834. 15DulicV,BeneyGE,FrebourgG,etal.Uncoupling betweenphenotypicsenescenceandcellcyclea rrestinagingp21-deficientfibroblasts[J].Mo lCellboil,2000,206:741-754. 16?????A.???????xRg1?????2???/?????L?J??p16 cyclinD1CDK4???????1??[J].?p???W?????8???L?? ????,2004.9(1):29-34. 17ChenXC,ZhuYG,WangXC.Protectiveeffectofginsen- osideRg1ondopamine-inducedapoptosisinPC12cell s[J].ActaPharmacolSin,2001.226:73-78. 18?Y????,??????,?W????,??.?????n???????2?)?F???? ????c-myc??????????[J].?p?[??,2001,23(5):356. 19??????,?Y?z,?W??,??.?????A?????????t?????u???? ?????K?F?H?????/???????O??[J].?p???p???h???,?j ??,1997,17(5):289. 20????,?G????,?E???I,??.?????,?j?J???K?????????8 ???/?O??[J].?p???????L?W???? ?8,2002,13(1):17-20. 21???E??.?F???p?h?????2?p?????????k?F?8??[J].?? ???k?F?L?????O??200231932-33.