[doc格式] “脑电超慢涨落图技术”在非屏蔽室内检测人脑神经递质分布的重测信度

[doc格式] “脑电超慢涨落图技术”在非屏蔽室内检测人脑神经递质分布的重测信度 “脑电超慢涨落图技术”在非屏蔽室内检测 人脑神经递质分布的重测信度 3W? ???;????33,?9??,?Z?????P?m??W3?????P???d???B(?????w?H ???????y);33,?????E??,???-???P??(????,???3) [?????h??]100925934(2008)2032131203W?[???L?]???3]W?AW?[?q???[????]W?R741.044;R742 ???????? oi?7?C???????x?????Ioa?H?????x???????? ???7?????.?H?[?(?????????? ?????w,??W???,??W??3 W?W?[??W???]W?????:?(??oi?7?C???????x?????Ioa?H?????x???????????7?????.?H?[?(???????m,?d?? ???????????H????W,????:?HW9?q??????????????W5???0??21?2?????????;,?H?????x??oi?7?C???????x ?[????oa?K??????????,??????????W990???????;??W5;5d?8???H?4???????H?4?j?????5?????fW,????: ?H?<?8?p?f?????q,???o?????;???[???3??W990???????;??W5??????11???]?]?q???????h?/???W?-?? ????,?4oi?7?C???????x?[????oa??????9?N?????.?H?[?(?]?]???????W?- ????????W,????:???????H?? ???x?????????????.?H?[?(???????????2??W, [???L??]W??7?C???????x?????I;?????.?H;?q?????????????? Thetest2retestreliabilityofanoiencephalofluctuographyoaapparatusdetectingthehuman brainneurotransmitterdistributioninanon2electromagneticshieldroom HUANGZhiqiang,LINing,WANGJie. NavalMedicalResearchInstituteNo.2MilitaryMedicalUniversity,Shanghai200433,China [Abstract]W?Objective:Toevaluatethereliabilityofoiencephalofluctuographyoa(EFG)apparatusde2 tectingthehumanbrainneurotransmitterdistributioninaroomwithoutelectromagneticshield.Methods: Twenty2onehealthysubjectsrecruitedthroughtheChinesePsychosomaticHealthScaleweretestedwith theSymptomChecklist290(SCL290),andthendetectedwiththeEFGapparatusinaroomwithoutelec2 tromagneticshield.TheSCL290testandEFGexaminationwereconductedagain5dayslateraccordingto thesamesequence.Results:TenofelevenindicantsfromSCL290,reflectingthesubjectsosstateofmind, showedsignificantcorrelationinthetest-reteststudy;whilenoneoftheninein dicantsaboutneuro2 transmitterdistributionfromtheapparatuswassignificantlycorrelated.Conc lusion:TheEFGapparatus isnotreliabletodetecttheneurotransmitterdistributioninthebrain,ifitisoper atedinaroomwithout electromagneticshield. [Keywords]W?Encephalofluctuography(EFG);Neurotransmitter;Chines ePsychosomaticHealth Scale W?W??7?C???x?????I(Encephalofluctuography, EFG,????oi?7EToa)[1] ??20?h??80???????y???q ?????d???B [2] ,?????r???r????W3?????5W3?????g?? ?r?????J?[??,?(???7?C???q??oi???????x?R?[oa,?r ???????w?)?[,???????l?m?W???o(?2(GA2 BA)W3?j?H??(Glu)W352(52HT)W3???????? (Ach)W3???v???9???o(NE)W3?r????(DA)?>?r???7 ?????.?H???????G?????????7????????,?4?????? ???.?H???????y?l?k??????,???????o?????;???? ?????[???3 [1] ,?H?P???????-?w???????????H????W, EFG???I???y????,?????H?2??????,?0?r?? ?????F?????????I?d????oi?7?C???????x?[????oaW3 oi?7???x????oa?h?;oi?7?????[????oa,?????????r?? ?P???h?d???w?????????????????????????????? W3?r????W3???y????W3?????????>?d?? [3-8] W,?2?7 ?????H???r???????x?K???????H????????,?7???? 2005??2?1?(???????????5???????????????mW, 1W??????????? ??????????????3?2???K?;,?;?????P???m?? ?????????y?2,???P???P???????2W,???q?j ??3?? ?S???????C?y?[???6??,2008??6?1,?Z17???Z3?y1JournalofClinicalElec troneurophysiology(China),June2008,Vol.17,No.3W?W? W?W? :2008-0-11 :2004: 2100102 0 1911 11 17?2,???m13?2W,????21??33??W, ???H???????y????oi?7?C???????x?[????oa,?? ???2?????;????EFG????(??????30min),???? EFG???????H?????????w????W9?q???????????? ??W5 [9] ??W990???????;??W5(SCL290)[10] W,W9?q?????? ????????W5???H?Z???f??????????,?H???E???????; ?????????????3;SCL290???o???????3,?H?????H ??EFG??????,???w?????????W???????H??????W, ?Z???f?????8?Z???f????????5?UW,?H?Z???f???? ?q,?????;?????????????????8?Z???f????W, 2W????? 2.1W????????????E?? ?F??W9?q??????????????W5??????????,????9 ?2???k?0???h????W3????????W3????W3?y???8???[??W3 ???????????????????????;,???521?2?????????; ????????W, 2.2W?SCL290?????????? ?HQodQ??????,????SCL290???m?r???]?] ?????????????2?<???3?[?(,?B???H?(??SCL290 ?p?f????????????????????,???HSpearman?>?? ????W,????1????,SCL290????1???????p?f???? ??????????(????????)?I????????,???w?p?f???? ???????;?????[???3???Z???4W,??????????1W, ??1W?SCL290?p?f??????????????(n=21) ?]?] ????????(M(QR))(1) ?Z???f?Z???f ?????? ??((?) P ?P?[W?W?9.00(18.00)7.00(9.50)0.7890.000 ?????hW?0.08(0.16)0.00(0.04)0.3610.108 ?w??W?W?0.20(0.20)0.10(0.30)0.6200.003 ???=????0.11(0.33)0.00(0.22)0.7640.000 ????W?W?0.08(0.31)0.08(0.15)0.7130.000 ?g??W?W?0.10(0.20)0.00(0.10)0.7770.000 ????W?W?0.00(0.25)0.00(0.17)0.7360.000 ???hW?W?0.00(0.07)0.00(0.14)0.9170.000 ????W?W?0.00(0117)0.00(0.17)0.4540.000 ???????m0.00(0.10)0.00(0.10)0.6940.000 ????W?W?0.14(0.29)0.14(0.21)0.4330.050 W?W???:(1)???????3?[?(?Q???????/?S?????[??????,M?w?q?? ??,QR=Q3odQ1,Q1??Q3?[?G?w?Z?????Z?0???[???? 2.3W???EFG????????oi?????.?H?[?(oa?????????? ???5QodQ???8,?????3?[?(??FG?]?]???? ????????,?????????3?[?(??FG?]?]?? ??Spearman?>??????(????2)W,????,?HEFG?? ?p?f?????????q,???0???N?]?]?I?-??????????W, ??2W???EFG?????????????o???q???????.?H ?S????????????(n=21) ?]?]W? ????????(?x??s?hM(QR)) (1) ?Z???f?Z???f ???? ???? P GABA6.76??3.823.95??3.630.0750.747 GA3.33??3.293.43??4.200.1950.396 AChR29.43??6.8631.38??7.81-0.2700.236 52HT22.00(6.50)20.00(8.00)0.0430.852 ACh15.71??7.4120.76??9.77-0.1160.618 oi?w????oa15.38??6.4413.14??6.280.1830.428 NE11.00(3.50)9.00(7.00)-0.4750.029 DA7.00(6.50)6.00(6.50)-0.0640.782 oi?????Ooa6.71??3.995.95??3.440.2210.336 3W????? ???N???????????????????????????????0?p?N ???Z??????:???????<?? [11] W,????(reliability)???? ?????m,???w???????????????m???M???m [12] ,???I ???????????B???R???w???????????????Z????[11] W, ????,?H???F???????????w?????4???N????????,?? ?U???????I??????,?8?U???????????0??????,?J?? ?8?????w????????,?????H??????????W,?<??(va2 lidity)?s???w???????????y???m???????m [13] ,???J ?I?????W???????????????]W,?????I?<?????????? ?? [11] W,???N?????????????0????,???J?????????? ???<??W, ?7?????????q,?H?u?k???O???????????????5 ?H?4?????:?H??oi?7EToa???J?4???????1????,?? ?r???????:?H???W??,?H?????2??????????,???G?I ?HSCL-90???w?????;?p?f?????????[???3???h ?2?m???????5,??EFG???????????7?????.?H?[?( ???p?f???????2????,?0???]?]?r?????????y????, ???8?H?????x???K???????H?????????????2??,?S ?????H??????W, ???H,?H???????????w???????????d???????? ?????r,?????????????????I?y?9?????G???????? ??W,?7???????????w,???I?y?9?H??????????????, ???????????????H????W,?7?????????I?????6?I ??,?w????????,?4???????????5???????nododod?H?? ?x?????5?(?????????????????2?mW, (?5???Z5??) ??3?? ?S???????C?y?[???6??,2008??6?1,?Z17???Z3?y1JournalofClinicalElec troneurophysiology(China),June2008,Vol.17,No.3W?W? W?W? E PearsonE10 21 1W?122???9?????????F???????;mMEPt????????[??(%)] ???G L4?,?ET12?,?E???6?,?E Ampf?/PLf????w?JAmpf?/PLf????w?JAmpf?/PLf????w?J CMCT?????P???,?E f???15(37.5)0(0)18(45.0)2(5.0)10(25.0)0(0)0(0)18(45.0)W? f???7(22.5)0(0)15(48.3)5(19)W?22(70.9)(1) 9(29.3)W?24(77.4)(1) 26(83.8)(1) f???0(0)0(0)0(0)0(0)12(23.5)18(35.2)20(39.2)30(58.8) (2) ?P??22(18.0)0(0)33(27.0)7(5.7)44(36.0)27(22.0)44(36.0)74(60.7)(3) W?W???:Ampf????w???=????,PLf????w???A?y????(?G???????A?y??????),CMCT?w???6PL?8T12PL?????kW,%???w???B?????G?????? ???[??W,(1)???w??(?2 ????,?8???p??????????????,P<0.05;(2)???w?8SSEPm????,P<0.05;(3)???w?8SEPt????,P>0.05 ?????H???????????????9???????q,?????1???H MEP???????9?????????????m,???L???S???P?y?? ????????????????W,?7???H?r?????S???????q???? ??,???r?S???9???????????????????;SSEPt???? ?T?2?????-?C???????????C??,?[???????8?????F ?????????h?9???????B???H?????0??W, ?????9????????,SSEPm???????????????F?? ?????0?????????y?m?????,?m,???M?m???8?-???? mMEPt(P<0.05),?8SEPt?????p?;?????M?m?? ???,???-???A?>(P>0.05),????,?????S???9???? ?????????????????F?????;,??????SSEPm???? ?w?S???????0???k???C?y?[?]?],?4?2?????? mMEPt??SEPt;???qN9-N13IPL?,?E?I?????? ?y???]?],???f?wN9-N20?,?E??N13?,?E;???? ?????????????????????F???????)1???,?E,???? ?wN9-N13ILD????,?S?????????1???0???????? ???F????W, SEPt?????????6?C??,?????0?N???????M?m?? ???,???-???A?>(P>0.05),???8????SEPt???9?? ???????0???????????k;?%??SSEPm???E?4SEPt ?,?E??,?s???w?????????H???????5,?=?????????? ?2?8???;,?????1???HSSEPm?8SEPt;SEPt?8 mMEPt????,?x???M?m?????,???-???A?>(P> 0.05),?%mMEPt?2???????w?9?????????????? ??,???????B???H?9???????????w?;???,?HW, ????1?????5??,mMEPt???????????????? ?M?m??????,???f?w?????????????F?????;,?%?P?M ?m??????60.7%,?[???????8?Z?d???????q?????? ?F?????B???????????0??,?d?????????[???????? ?F?????;mMEPt???E(???M?m????45%),???8 mMEPt???????9???????????y?m?m???????F?? ??,?%?????????????????d??????W, 4W????(???L [1]W??t????,??????,???x,?>.?9?????????;???y?????C???????? ???8?p?????????m[J].?q???S?????2,2002,6(18):2703- 2704. [2]W??w??,?S?2?0,??????,?>.???8???????y?????C?????9?????? ??????????[J].?S???7?C???6??,1998,7(4):203-206. [3]W???????.?S?????C????[M].?e???P???m???e???????P???m?? ???1???<?-,1995.138-142,155-157. (?9???Z132??) 4W????(???L [1]W?????.ETod?7?????????????I[M].?e??:???v???r???<?-, 1995.91,192,2561 [2]W?????,?t?1??,???t??.???????3?5?7?????????x???[??[J].?N ?U?P???8?P?????5,1989,2(3):157-163. [3]W???????,??????,?????b,?>.?7?C???????x?????I?H???d?? ?q?????H[J].?q?????H?y?[???6??,2000,16(3):286-288. [4]W???????,?t????,?????b,?>.???????5?q?7?C???????x??S?J ?????h?d??[J].?q?????w?P??????,2000,9(3):196-197. [5]W????u??,?????,,??????.?3?????%???;???7?????8?7???x???[ ??[J].?q?????2?P???6??,2002,17(4):249-250. [6]W????]??,?????q,?t???y?q?A???y???????????7?C???d??[] ???[?8???w?d??,3,()5 [7]W??<????,?<???U,????,?>.?7???x???q?????.?H???h?8?7???q ?8????????[J].?q???S?????2,2005,9(16):118-119. [8]W??????a.???????????[?????w?????7?C???????x???[??[J].?S ???????C?y?[???6??,2006,15(3):182-183. [9]W??o?[?>,??????,?d??,?>.?q?????????????????h?O???E?f [J].?9???????P??,1993,5(??1):24. [10]W???????.????????????(SCL290)[J].?9???????P??,1984,2: 69-70,93-95. [11]W??S????.???[?8????????[M].?9??:???i?1?(?m?????<?-, 1987.190,192,222. [12]W??o????.????.??:?q???m????????[M].???[??.?e??:?q???m ???????????<?-,1991.460. [13]W??o????.?<??.??:?q???m????????.???[??[M].?e??:?q???m ???????????<?-,3 ??5?? ?S???????C?y?[???6??,2008??6?1,?Z17???Z3?y1JournalofClinicalElectroneurophysiology(China),June2008,Vol.17,No.3W?W? W?W? .J. 20011:-10. 1991.40. 01