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首页 > 英语科普小知识白细胞对控制红细胞数量起关键作用

英语科普小知识白细胞对控制红细胞数量起关键作用

2017-11-22 5页 doc 22KB 11阅读

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英语科普小知识白细胞对控制红细胞数量起关键作用英语科普小知识白细胞对控制红细胞数量起关键作用 海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm (申请网址) Researchers at Albert Einstein College of Medicine of Yeshiva University and the Icahn School of Medicine at Mount Sinai have found that macrophages(巨噬细胞) -- white blood cells that play a ...
英语科普小知识白细胞对控制红细胞数量起关键作用
英语科普小知识白细胞对控制红细胞数量起关键作用 海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm (申请网址) Researchers at Albert Einstein College of Medicine of Yeshiva University and the Icahn School of Medicine at Mount Sinai have found that macrophages(巨噬细胞) -- white blood cells that play a key role in the immune response -- also help to both produce and eliminate the body's red blood cells (RBCs). The findings could lead to novel therapies for diseases or conditions in which the red blood cell production is thrown out of balance. The study, conducted in mice, is published today in the online edition of the journal Nature Medicine. "Our findings offer intriguing(有趣的) new insights into how the body maintains a healthy balance of red blood cells," said study leader Paul Frenette, M.D., professor of medicine and of cell biology and director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Einstein. "We've shown that macrophages in the bone marrow and the spleen(脾脏) nurture the production of new red blood cells at the same time that they clear aging red blood cells from the circulation. This understanding may ultimately help us to devise new therapies for conditions that lead to abnormal RBC counts, such as hemolytic anemia(溶血性贫血), polycythemia vera, and acute blood loss, plus aid recovery from chemotherapy and bone marrow transplantation." Einstein has filed a joint patent application with Mount Sinai related to this research, which is currently available for licensing and further commercialization. Previous studies, all done in the laboratory, had suggested that macrophages in the bone marrow act as nurse cells for erythroblasts, which are RBC precursors. But just how these "erythroblastic islands" (macrophages surrounded by erythroblasts) function in living animals was unclear. A few years ago, Andrew Chow, a Mount Sinai M.D./Ph.D. student in the laboratories of Drs. Frenette, and Miriam Merad, M.D., Ph.D., professor of oncological sciences and immunology at Mount Sinai found that bone marrow macrophages express a cell surface molecule called sialoadhesin, or CD169 -- a target that could be used for selectively eliminating macrophages from bone marrow. Doing so would help pinpoint the role of macrophages in erythroblastic islands in vivo. That's what Drs. Frenette and Merad did in the current study involving mice. They found that selectively eliminating CD169-positive macrophages in mice reduces the number of bone marrow erythroblasts -- evidence that these macrophages are indeed vital for the survival of erythroblasts, which develop into RBCs. "What was surprising is that we couldn't see any significant anemia afterward," said Dr. Frenette. The researchers then analyzed the lifespan of the red blood cells and found that they were circulating for a longer time than usual. "After we depleted the macrophages in the bone marrow, we discovered that we had also 洛基国际英语 竭诚为您服务 海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm (申请网址) depleted CD169-positive macrophages present in the spleen and liver. It turns out that the macrophages in these two organs are quite important in removing old red blood cells from the peripheral circulation. Taken together, the findings show that these macrophages have a dual role, both producing and clearing red blood cells," he said. 在阿尔伯特?爱因斯坦医学院的叶史瓦大学和伊坎在西奈山医学院的研究人员发现,巨噬细胞(巨噬细胞) -白血细胞,在免疫反应中发挥了关键作用-也有利于双方生产和消除人体的红血细胞(红细胞)。这一发现可能导致新疗法的红血细胞的生产平衡是扔出的疾病或情况。在小鼠中进行的研究,今天发表在“自然医学”(Nature Medicine)杂志的网络版。 “我们的发现提供了有趣(有趣的)新的见解身体如何保持一个健康的平衡的红血细胞,说:“研究的负责人保罗弗雷内特,医学博士,医学教授,细胞生物学和主任露丝L.的David S戈特斯曼研究所干细胞与再生医学研究在爱因斯坦。“我们已经证明,巨噬细胞在骨髓和脾脏(脾脏)培育新的红血细胞的生产,同时他们清除衰老的红细胞从流通。这种理解可能最终帮助我们设计出新疗法条件,导致异常的红细胞计数,如溶血性贫血(溶血性贫血),真性红细胞增多症,急性失血,再加上从化疗和骨髓移植的急救复苏。爱因斯坦曾联合提交了一份专利申请西奈山有关这项研究,这也是目前市面上的许可,并进一步商品化。 以往的研究都在实验室做的,建议作为护士的红细胞,这是红细胞前体细胞在骨髓中的巨噬细胞。但是,仅仅这些“幼红细胞岛”(巨噬细胞所包围红细胞)功能在生活的动物是如何尚不清楚。 几年前,安德鲁周,西奈山医师/博士。学生在博士的实验室。弗雷内特仪Merad,医学博士,肿瘤学和免疫学教授在西奈山发现,骨髓巨噬细胞表达细胞表面分子称为sialoadhesin,或CD169 - 一个目标,选择性地消除巨噬细胞可用于骨髓。这样做将有助于查明在体内红细胞岛屿的巨噬细胞的作用。 这是什么博士。弗雷内特Merad在目前的研究涉及小鼠。他们发现,有选择地消除CD169阳性的巨噬细胞在小鼠骨髓红细胞的数量减少 - 的证据表明,这些巨噬细胞确实是至关重要的红细胞的生存,发展成红细胞。 “令人意外的是,我们看不到任何重大贫血之后,说:”博士弗雷内特。然后,研究人员分析了红血细胞的寿命,发现他们比平常更长的时间循环。 “当我们耗尽了巨噬细胞在骨髓中,我们发现,我们也所剩无几了CD169阳性巨噬细胞在脾脏和肝脏事实证明,在这两个机构中的巨噬细胞是非常重要的,在删除旧的红血细胞。末梢循环,两者合计,调查结果表明,这些巨噬细胞具有双重作用,红血细胞的生产和清除,“他说。 “成千上万人疯狂下载。。。。。。 洛基国际英语 竭诚为您服务 海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm (申请网址) 更多价值连城的绝密英语学习资料, 洛基内部秘密英语,技巧,策略 请在 网上 申请报名” 洛基国际英语 竭诚为您服务
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