安徽国正药业股份有限公司成立于二00三年十二月

安徽国正药业股份有限公司成立于二00三年十二月 关于国正药业股份有限公司从事生产岗位的实习报告 一、实习目的 实习目的:熟悉药品生产工艺流程，学习各车间物料流程，加强GMP知识和安全知识的学习，把理论与实践相结合。了解药厂厂区布局，车间布局，熟悉相关原则。通过在各个不同部门的日常工作，体验上班族的生活，丰富专业知识，积累工作经验，提高沟通及人际关系处理能力，为以后走上工作岗位打下坚实基础。找到自身不足之处，早日弥补，增强自己对社会的适应能力。 1、安徽国正药业股份有限公司简介:安徽国正药业股份有限公司成立于二00三年十二月，是由安徽国风集团控股的一家专业从事药品研发、生产加工与销售的股份制公司。公司位于合肥市经济技术开发区烟墩路，占地40多亩。公司注册资本4000万元，法定代表人为张继凤。目前公司拥有员工150多人，其中各类专业技术人员50多人。本科学历以上人员30多人。安徽国风集团有限公司是拥有两家上市公司，总资产超过43亿元的大型集团公司，安徽省十八家重点企业集团之一，其中塑料薄膜、塑管型材、塑料建材及非金属超细粉等主导产品处于全国领先水平。 2004年6月，公司通过国家GMP认证，建立了完善的质量管理体系，严格按照国家药品管理法规要求进行生产和销售。目前公司拥有片剂、胶囊剂、颗粒剂、糖浆剂、酊水剂、外用制剂等六大剂型120多个品种，保健食品8个品种，主导产品有:国家三类中药七味养心健脾胶囊，国家二类新药那格列奈，复方甘草片(国家定system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment 点品种，每省限一家)，组合抗结核药(利福平胶囊、乙胺丁醇片、导烟肼片、吡嗪酰胺片组合包装)、抗菌药诺氟沙星胶囊，抗生素药乙酰螺旋霉素片，抗生素药头孢氨苄薄膜衣片，国正氨咖黄敏胶囊等。公司产品通过国内大型的药品物流中心销往山东、陕西、湖北、福建等地区，进入分布全国的药品市场的零售终端。通过有效的市场开拓，构建了稳固的市场销售网络，拥有一批稳定的客户群，同时锻炼和培养了专业化销售队伍。 国正药业以“树国正之正气，保民之安康”为己任，注重新产品的研制开发工作，视产品质量为企业命脉，公司秉承“和谐国风”精神，坚持以人为本，加强企业文化建设和员工素质教育，打造和谐发展、高效益企业。用自身的发展推动国风医药产业的壮大，以实际行动为医药事业的兴盛作出更大的贡献。 2:生产车间简介:安徽国正药业股份有限公司目前公司拥有片剂、胶囊剂、颗粒剂、糖浆剂、酊水剂、外用制剂等六大剂型120多个品种，保健食品8个品种，主导产品有:国家三类中药七味养心健脾胶囊，国家二类新药那格列奈，复方甘草片(国家定点计划品种，每省限一家)，组合抗结核药(利福平胶囊、乙胺丁醇片、导烟肼片、吡嗪酰胺片组合包装)、抗菌药诺氟沙星胶囊，抗生素药乙酰螺旋霉素片，抗生素药头孢氨苄薄膜衣片，国正氨咖黄敏胶囊等。安徽国正药业股份有限公司日常生产的主要药物是复方甘草片和开塞露。生产车间拥有40多名生产、包装人员，分为多个包装小组，并设班长一名，负责一种药品的生产、包装任务。生产车间的任务是system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment 每天在五点30分之前生产出1或2批药品，每一批药品为34至36箱不等。开塞露是安徽国正药业股份有限公司的主要产品之一，几乎每一天都要生产1到2批，开塞露是一种润滑剂，其成分主要是由甘油和其他辅助药物组成。临床上通常运用开塞露刺激肠壁引起排便反射来协助排便。开塞露的成分是净化水和甘油，开塞露中每100毫升中含甘油62。5毫升的甘油。在生产开塞露的时候首先将称好重量的甘油和净化水倒在搅拌机器里搅拌，然后经瓶装线装瓶，之后包装储存。 复方甘草片是安徽国正药业股份有限公司最主要的产品，是镇咳祛痰类非处方药药品。安徽国正药业股份有限公司是安徽地区唯一授权生产企业。复方甘草片中每片含甘草流浸膏粉112.5毫克、阿片粉4毫克、樟脑2毫克、八角茴香油2毫克、苯甲酸钠2毫克。复方甘草片中阿片粉有较强镇咳作用;樟脑及八角茴香油能刺激支气管黏膜，反射性地增加痰量使痰易于咳出;苯甲酸钠为防腐剂。上述成份组成复方制剂，有镇咳祛痰的协同作用。复方甘草片为“老牌”的祛痰止咳药，由于有良好的祛痰镇咳作用及价廉的特点，仍然在止咳药中占有一定的位置，尤其在广大农村仍在广泛使用。复方甘草片每一年生产4到5批，每一批生产5000万粒，分23个批次生产。复方甘草片的生产由制粒，压片，瓶装，包装四部分组成。 system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment 二、实习内容 按照新华学院药学院的安排， 2011年2月28号我们来到了安徽国正药业股份有限公司开始了为期七周的实习工作。在这里我学会了自主，学会了要尽自已的努力做到最快、做到最好、更要做到细心。 来到安徽国正药业股份有限公司以后我被领导安排在了生产部，我在为期七个星期的实习期间里先后从事过开塞露的包装、开塞露生产、物料配送、复方甘草片的包装、复方甘草片生产车间的压片、制粒等岗位的工作。我首先从事的是包装工作。我国《药品管理法》设药品的包装和分装专章，对药品包装问作了专门。其中包括 :药品包装之标签或说明书上必须注明药品的品名、规格、生产企业、批准文号、产品批号、主要成分、适应症、用法、用量、禁忌、不良反应和注意事项。药品包装材料的要求:1、一定的机械性能2、隔性能3、良好的安全性能4、合适的加工性能5、较好的经济性能 根据国家药品监督管理局第23号局令，进一步加强和药品的包装、标签管理，确保《药品包装、标签和说明书管理规定》(暂行)的贯彻实施，特制定本细则。 开塞露是缓泻药类非处方药品。是一种润滑剂，其成分主要是由甘油、净化水和其他辅助药物组成。临床上通常运用开塞露刺激肠壁引起排便反射来协助排便。用于小儿及老年体弱便秘者的治疗。开塞露能润滑并刺激肠壁，软化大便，使其易于排出。其主要原理是利用甘油带来的高渗作用，让更多的水分渗入肠腔，软化大便，刺激肠壁，system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment 反射性地引起排便反应。同时，甘油本身也能起到一定的润滑作用。因此，开塞露属于刺激性泻药，和中药里的大黄原理很相似。开塞露效果直接。 物料配送是为了保证日常生产的正常、有序的生产。为各个生产车间的按时提供物料供给。物料配送有严格的要求。以在生产复方甘草片是领取阿片粉为例，每天上午9点30分和下午的1点30分由两名,,人员的陪同下领取运送的生产车间的传递窗里紫外灯消毒,,分钟，之后由生产车间人员领取。在生产车间内取用规定的阿片粉后由传递窗送出，最后送回仓库。全程都在,,人员和监控设施的监控下完成，并做详细的。物料配送要求准时、准确。要求每天按时、按量配送物料，并详细的记录下领取的时间和数量，确保应出物料与实际出的物料一样。 制颗粒的目的中西药片剂绝大多数都需要事先制成颗粒才能进行压片，这是由原料物性所决定的。制成颗粒主要是增加其流动 性和可压性。流动性常以休止角表示，休止角小流动性好，否则相反。可压性最简单的衡量方法是以压成一定硬度的药片所需的压力表示，若所需压力小则可压性 好;或以在一定压力下压成药片的硬度表示，若硬度大则可压性好。颗粒的制备是湿颗粒法制片的关键操作，关系到压片能否顺利进行和片剂质量的好坏。具体目的 如下。(1)增加物料的流动性:细粉流动性差，不能从饲料斗中顺利地流入模孔中，时多时少，增加片剂的重量差异，也影响片剂的含量，制成颗粒后增加了流动性。药物粉末的休止角一般为65度左右，而颗粒的休止角一system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment 般为45度左右，故颗粒的流动性好于粉末。(2)减少细粉吸附和容存的空气以减少药片的松裂:细粉比表面积大，吸附和容存的空气多，当冲头加压时，粉末中部分空气不能及时逸出而被压在片剂内，当压力移去时，片剂内部空气膨胀以致使片剂松裂。(3)避免粉末分层:处方中有数种原、辅料粉末，密度不一，当在压片过程中，由于压片机的振动，使重者下沉，轻者上浮，产生分层现象，以致含量不准。(4)避免细粉飞扬:细粉压片粉尘多，粘附于冲头表面或模壁，易造成粘冲、拉模等现象。 压片是复方甘草片在生产车间的最后一道工序，其要求压出的每一粒药片的重量都在要求的范围内，如出现错误可导致药片药品用在患者身上起不到预期效果，影响企业形象。在压片时每三十分钟加料，称重一次，如有误差必须及时的调整机器，使药片重量回的正常范围。 三、实习结果 实习体会实习是对一个应届大学毕业生来说非常重要的经历，实习是我们离接触社会的一个平台，最真实地感受社会的一个窗口。这次在国正药业股份有限公司为期的实习生活让我学到了很多东西，对我而言有着十分重要的意义。我更深刻的了解社会，更便捷的融入社会，在实践能力上也得到了提高，真正地做到了学以致用，让我学到了许多书本上学不到的东西，有效的锻炼了自己，长了见识，开拓了视野，实习是我们把学校学到的理论知识应用在实际中的一次尝试，是我们迈向社会的第一步，通过这次实习，我发现了不少问题，自己的缺点、不足，早该摒弃的陋习，逐渐被自己所认知，自己所学知识的肤浅，system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment 专业知识在实际运用中的匮乏让我明白我需要学习的太多，使我熟悉到必须让自己了解才能在当今竞争激烈的社会中拥有一席之地。 四、致谢 十分感谢安徽国正药业股份有限公司，给了我这样一次宝贵的实习机会，让我对未来的工作、学习有了更深刻的理解和认识。我是即将走上工作岗位的大三学生，通过这次实习，让我对未来充满了信心。在安徽国正药业股份有限公司实习的这段时间里，部门领导和同事也都尽力帮助我，给我讲授相关的知识，耐心细致的教授我如何解决现实工作中的问题。在和谐的气氛中我在安徽国正药业股份有限公司工作学习了七个星期，在这里，我不仅学会如何运用了所学的专业知识解决问题，加深了对所学专业知识的理解和认识，为以后更好的学习指明了方向，而且还学会了如何与人和谐相处，如何处理好与领导、同事的关系，丰富了我的社会实践经历，阔大了知识面，为我即将踏入社会奠定了很好的基础。 在这里我对感谢安徽国正药业股份有限公司表示诚挚的感谢，并祝愿感谢安徽国正药业股份有限公司以后的发展越来越好。 system troubleshooting. Integrated wiring system should have enough redundancy, can meet the development requirements. Rehabilitation Center backbone transmission using single-mode 12-core optical fibers, full reserve reserve to meet current and future period trunk signal transmission needs, rehabilitation center for future facility expansion needs. convenient and economical. Intranet and the Internet using a set of structured cabling systems. Medical treatment building, aerial parts of each layer on the rehabilitation floor weak current equipment set up between two 2 m network equipment cabinet, assigned to internal and external network devices. basement underground two-level shared network equipment rack. Medical treatment building intranet and extranet communication optical cable from the medical information room of the building leads, along the medical floor weak current tube into each layer individually weak current equipment. Recovery building intranet and extranet communication optical cable from medical and rehabilitation of ground floor one floor basement corridor into the rehabilitation floor weak current lines1th, floor and 2nd, floor of intranet and outside network of communications cable since medical integrated floor of information room leads, along rehabilitation center of weak tube respectively into 1th, floor of East, in the, West three seat floor a layer of weak equipment