肿瘤信号通路图

肿瘤信号通路图 肿瘤信号转导基因芯片包含了与肿瘤形成15个信号转导通路特定标 志物基因。这些信号通路包括:MAPK通路、WNT通路、Hedgehog通路、 STAT通路、应激通路(DNA损伤通路、p53通路、缺氧通路、热激通路、 及p38 / JNK通路)、炎症通路(Cox-2通路与NF-κB通路)、survival通路 (NF-κB通路与PI3K / AKT通路)、激素通路(雌激素与雄激素通路)，以 及抗细胞增殖通路(TGFβ通路)。肿瘤的特征取决于原发组织及遗传和环 境因素。每种肿瘤都是特定的信号通路组合的激活或失活所致。对多重信 号通路的可以快速了解决定肿瘤生成的可能路径。这张芯片不仅用于 检测与特定肿瘤相关的信号通路，而且可用于检测肿瘤类型。使用这一芯 片试剂盒检测RNA实验标本，操作者通过简便的杂交反应技术，即可同时 检测上述和肿瘤形成相关的信号转导通路内标志物基因的表达水平变化。 Androgen Pathway: CDK2, CDKN1A (p21Waf1/p21Cip1), EGFR, FOLH1, KLK2 (hGK2), KLK3 (PSA), TMEPAI. Cox-2 Pathway: FOS, HSPA4 (hsp70), MCL1, PPARG, PTGS2 (Cox-2), TNFRSF10B (DR5). DNA Damage / p53 Pathways: BAX, BCL2, CDKN1A (p21Waf1/p21Cip1), GADD45A (gadd45), HIF1A, HSPA4 (hsp70), IGFBP3, MDM2, PIG3, TNFRSF6 (Fas), TNFRSF10B (TrailR/DR5), TRAF1, WIG1. Estrogen Pathway: BCL2, BRCA1, CTSD (cathepsin D), EGFR, PGR (PR), ZNF147 (Efp). Hedgehog Pathway: BMP2, BMP4, EN1 (engrailed), HHIP, FOXA2 (HNF3B), PTCH, PTCH2, WNT1, WNT2, WSB1. Hypoxia Pathway: ADRA1B, CDKN1A, EDN1, EPO, HK1, HMOX1 (HO-1), IGFBP3, NOS2A (iNOS), SLC2A1, TF, TFRC, VEGF. Inflammation / NF-κB Pathways: ICAM1, IL2, LTA (TNFb), NF-ΚB1 (NF-κB), NF-ΚBIA (IκBa), NOS2A (iNOS), PECAM1, TNF (TNFa), VCAM1. MAP Kinase Pathway: COL1A1 (Collagen I), EGR1 (egr-1), FOS (c-fos), JUN (c-jun). PI-3 Kinase / AKT Pathways: BCL2, CCND1 (cyclin D1), FN1 (fibronectin), HIF1A, JUN (c-jun), MMP7 (matrilysin), MYC (c-myc), TNFSF10 (TRAIL) STAT Pathway: A2M (a2macroglobulin), BCL2, BCL2L1 (Bcl-XL), CSN2 (b –casein), CXCL9 (MIG), IL4, IL4R, IRF1, MMP10 (stromelysin-2), NOS2A (iNOS). Stress / Heat Shock Pathways: HSF1 (tcf5), HSPA4 (hsp70), HSPB1 (hsp27), HSPB2, HSPCA (hsp90) Stress / p38 & JNK Pathways: ABCB1 (Mdr1), ATF2, COL1A1 (Collagen I), DUSP1 (MKP1), ENPP2 (Autotaxin), FOS, HSPA4 (hsp70), HSPA5 (Grp78), HSPB1 (hsp27), HSPB2, MYC, TP53. Survival / NF-κB Pathway: AKT1, BCL2A1 (Bfl-1/A1), BCL2L1 (Bcl-xL), BIRC1 (NAIP), BIRC2 (c-IAP2), BIRC3 (c-IAP1), TNFAIP3 (A20), TRAF1. TGFB Pathway: CDKN1A (p21Waf1, p21Cip1), CDKN1B (p27), CDKN1C (p57Kip2), CDKN2A (p16Ink4), CDKN2B (p15 Ink2b), CDKN2C (p18, cdk4 inhibitor), CDKN2D (p19). Wnt Pathway: ABCB1 (Mdr1), BMP4, CCND1 (cyclin D1), ENPP2 (Autotaxin), FOSL1 (Fra-1), ID2, JUN (c-jun), MMP7, MYC (c-myc), VEGF, WISP1.