头皮健康的生物标志

头皮健康的生物标志 Epidermal changes associated with symptomatic resolution of dandruff: biomarkers of scalp health 表皮变化与对症解决头皮屑有关:头皮健康的生物标志 Abstract 摘要 Objectives This study aimed to better characterize the state of the epidermis in dandruff and to determine how a defined set of skin surface biomarkers of this state change during a successful course of treatment with a potentiated zinc pyrithione (ZPT) shampoo. 目的:本研究旨在更好的表征头皮屑表皮的状态，并确定在用加强的ZPT 洗发水治疗成功时如何定义皮肤表面生物标志状态的改变。 Methods A population of dandruff sufferers was treated for 3 weeks with a commercial ZPT shampoo or a non-medicated product, and the effect of treatment on adherent scalpflake (ASF) scores was evaluated. Biopsies were taken from lesional sites at baseline and at the end of the study for histomorphometric and histopathologic analysis. Stratum corneum (SC) samples were likewise obtained for evaluation of biochemical markers of inflammation (IL-1a, IL-1RA, IL-8) and barrier integrity (keratin 1, 10, 11; involucrin; SC lipids; human serum albumin). The biomarker profile was evaluated first by comparison with that in non-dandruff subjects at baseline, and then to determine whether any treatment-induced changes were correlated with reductions in flaking in dandruff sufferers. 方法:头皮屑患者用商业的ZPT洗发水或者非药物产品治疗3周，以附着 头皮碎片(ASF)分数评估治疗效果。活检受损部位边缘并在研究结束时做组织 形态学和组织病理学。同样获取角质层(SC)样品用于评估炎症(IL-1a、 IL-1RA、IL-8)的生物标志物和屏障完整性(角蛋白1、10、11，外皮蛋白，SC 血脂，人血清白蛋白)。首先与基底的非头皮屑相比较来评估生物标记的外形， 然后才能确定由治疗引起的变化是否与头皮屑患者皮屑剥落减少有关。 Results Taken together, our studies showed that treatment with the ZPT shampoo led toan improvement in the overall scalp condition as assessed by the resolution of flaking,reduction in epidermal thickness and inflammatory biomarkers, and a dramatic improvementin biomarkers of epidermal barrier integrity. 结果:总之，我们的研究表明，用ZPT洗发水治疗，通过评估头皮碎片分 布，头皮状况全面改善，减少表皮厚度和炎症标志物，表皮屏障完整性的标志物 也显著改善。 Conclusions The combination of biomarkers examined appears to be a good overall descriptor of the health of the scalp in dandruff, and changes in these biomarkers track with tissue-level events that underlie clinical efficacy in the treatment of dandruff by ZPT shampoo. For the first time, we demonstrate a set of tools that extend beyond flaking scores to provide insight into specific biological changes occurring on the scalp to enable an objective assessment of scalp health. 结论:结合研究标志物似乎能很好的全面描述头皮屑头皮的健康，对用ZPT 洗发水治疗头皮屑潜在的临床效果进行组织水平这些生物标志物变化的追踪。我 们首次论证了一套用品，尽可能展开头皮碎片，提出发生于头皮具体生物学变化 的见解，使能够达到评估头皮健康的目的。