脑瘫论文：脑瘫 脐带间充质干细胞 综合康复疗法

脑瘫论文：脑瘫 脐带间充质干细胞 综合康复疗法 脑瘫论文:脑瘫 脐带间充质干细胞 综合康复疗法 【中文摘要】探讨脐带间充质干细胞移植结合综合康复疗法治疗脑瘫的临床效果,为脑瘫患儿的临床治疗提供理论依据。方法采用完全随机设计,将59例符合纳入标准的脑瘫患儿按着接受治疗的时间顺序随机分为A组(综合康复组)B组(综合康复疗法结合脐带间充质干细胞.组),疗程为3月,治疗前、后分别对两组患儿的日常生活活动能力(ADL)和粗大运动功能进行评定,并对临床疗效及与不同年龄段的关系进行观察。结果(1)两组患儿采用日常生活活动能力(ADL)评分、粗大运动功能(GMFM)评分治疗前、后比较差异显著,有统计学意义(P0.05)(2)治疗后,治疗组的日常生活能力评分、GMFM评分与对照组相比差异显著,有统计学意义(P<0.05)。(3)治疗后,治疗组的临床疗效与对照组相比差异显著,有统计学意义,两个年龄段疗效比较,差异具有统计学意义。结论(1)在对脑瘫患儿康复治疗中,两组均改善脑瘫患儿的粗大运动功能,提高ADL能力(2)治疗组在各项指标的评估中均优于对照组。由此说明,可以应用脐带间充质干细胞来治疗脑瘫患儿的日常生活活动能力和粗大运动功能障碍。(3)治疗组的临床疗效优于对照组,说明脐带间充质干细胞可以用于脑瘫的临床治疗,经两个年龄段疗效比较,脑瘫患儿应注重早期治疗。 【英文摘要】Explore umbilical cord mesenchymal stem cell transplantation combining comprehensive rehabilitation therapy the clinical effect of cerebral palsy, for the clinical treatment of children with cerebral palsy to provide the theory basis.MethodsThe design scheme will be completely random,59 patients meet eligibility criteria of cerebral palsy children treated according to the time sequence randomly divided into A group (group) comprehensive recovery group B (comprehensive rehabilitation therapy combined with umbilical cord mesenchymal stem cells group), treatment for 3 months before treatment, respectively, after two groups of children activities of daily life ability (gross motor function and latched) were evaluated, and the clinical curative effect and the relationship between the different age paragraph observation.Results(1) the two groups of children of the daily life activities (ADL) score, bulky latched movement function (GMFM) score before and after the treatment is significant, and the difference was statistically significant (P0.05)(2) after treatment, the daily life of the treatment group ability score, compared with control GMFM score difference was statistically significant (P< 0.05).(3) after treatment, the clinical curative effect of the treatment group compared with control, a significant difference was statistically significant, the two age groups, the difference has the result was statistically significant.Conclusion(1) in children with cerebral palsy to rehabilitation treatment, both groups to improve children with cp gross motor function, improve the latched ability.(2) the treatment group in each index in the assessment of the are better than control. This implies that can be applied to the umbilical cord mesenchymal stem cells to treat children with cerebral palsy activities of daily life ability and gross motor dysfunction.(3) the clinical curative effect of the treatment group than in control group, explain umbilical cord mesenchymal stem cells can be used in the clinical treatment of cerebral palsy, the two age groups, cerebral palsy children result was should notice early treatment. 【关键词】脑瘫 脐带间充质干细胞 综合康复疗法 【采买全文】 1.3.9.9.38.8.4.8 1.3.8.1.13.7.2.1 同时提供论文写作定制和论文发服务.保过包发. 【说明】本文仅为中国学术文献总库合作提供，无涉版权。作者如有异议请与总库或学校联系。 【英文关键词】cerebral palsy umbilical cord mesenchymal stem cells comprehensive rehabilitation therapy 【目录】脐带间充质干细胞移植结合综合康复疗法治疗脑瘫的临 床观察 缩略语表 3-4 摘要 4-5 ABSTRACT 5-6 前言 7-9 综述 9-17 一、小儿脑瘫的认识 9-11 二、间充质干细胞的概念及特性 11-14 三、脐带间充质干细胞 移植治疗脑瘫的可能性 14-16 四、展望 16-17 临床研究 17-23 一、临床资料 17-20 (一) 病例选择与分组 17 (二) 病例诊断标准、入选标准及排除标准 17-18 (三) 治疗方法 18-19 (四) 康复评定及疗效评定标准 19-20 (五) 统计学分析 20 二、研究结果 20-23 讨论 23-33 一、脑瘫治疗 23-27 二、关于干细胞治疗 27-32 三、干细胞结合综合康复治疗脑瘫的临床价值 32-33 结论 33-34 致谢 34-35 参考文献 35-40 附表 40-46 个人简介 46