明胶海绵粉末栓塞犬髂内动脉2

明胶海绵粉末栓塞犬髂内动脉2 中组组工程究国研 2013, Vol. 17 Issue (8): 1418-1422 DOI: 10.3969/j.issn.2095-4344.2013.08.015 材料生物相容性 material biocompatibility 明海组粉末栓塞犬组组组胶内脉 Embolization of dog’s bilateral internal iliac arteries with gelfoam powder 全文: PDF (522 KB) 摘要 背景,明海组已成组骨组瘤组前栓塞的首组材料～但组组小组粒明海组组栓塞效果及栓塞后组症胶骶胶并 的影未组明组道。响确 目的,组察小组粒明海组栓塞犬组组组后手组出血量组化和组组症情组。胶双内脉并况 方法,用直组径50-150 μm明海组粉末组胶15只犬行组组及正中组组栓塞～分组于栓塞后双内骶脉 1～2～3 d模组骨组瘤手组组量出血量组化～病理组察栓塞膀胱、直组、臀部肌及坐骨神组组化。骶区 组果组组,与栓塞后第3天出血量高于第1～2天(P < 0.05)～栓塞后第1天第与2天出血量 差无组著性意组异(P > 0.05)。在用直组运径50-150 μm明海组粉末栓塞犬组组及组正中组胶双内骶 脉脉组～最小组是50 μm的微组～但主要集中在脉100-200 μm小组～字影血管造影下组脉数减 示栓塞组组及正中组组近端血管组组组其一组分支～此组犬盆腔组器组组无明组组化。双内骶脉 组组组 , 生物材料～ 材料生物相容性～ 生物材料基组组组～ 明海组粉末胶～ 组组组内脉～ 栓塞～ 血管造 影～ 骶骨组瘤～ 省组基金～ 生物材料组片文章～ Abstract, BACKGROUND: Gelfoam has become the preferred embolization agent for preoperative embolism in the operation of sacral tumor, but the contribution of small gelfoam to embolization effectiveness and postoperative complications has not been definitely reported. OBJECTIVE: To observe the changes in intraoperative bleeding and complications following embolization of dog’s bilateral internal iliac arteries with gelfoam powder. METHODS: The bilateral internal iliac and median sacral arteries of fifteen dogs were embolized using gelfoam powder with a diameter of 50-150 μm. Then, the operation of sacral tumor was imitated to measure intraoperative bleeding at 1, 2, and 3 days after embolization, observing pathological alteration of pelvic organs. RESULTS AND CONCLUSION: The mean intraoperative bleeding was higher at 3 days than at 1 and 2 days (P < 0.0.5), but it was no difference at 1 and 2 days (P > 0.05). When gelfoam power with a diameter of 50-150 μm was employed to embolize the bilateral internal iliac and median sacral arteries, the smallest embolized artery was arteriole whose diameter was about 50 μm, but embolized arteries were mainly arterioles with a diameter of 100-200 μm. The first-class branches of embolized bilateral internal iliac and median sacral arteries were reserved which were displayed on the digital subtraction angiography. In addition, pelvic organs had no obvious pathological alteration. Key words, biomaterials; material biocompatibility; basic experiments of biomaterials; gelfoam powder; internal iliac artery; embolism;angiography; sacral tumor; provincial grants-supported paper; biomaterial photographs- containing paper; 收稿日期: 2012-11-06 中组分组号: R318 研究亮点: 1 明海组具有价格低廉、组组相容性好、位栓塞后危组性低等组点～已成组骨组瘤组前栓塞的首胶异骶 组～但明海组的可吸收性常常组栓塞后最佳手组组限组组格的限制～同组其不同大小的组粒组必组生胶来将 不同的栓塞效果及栓塞后组症。组组用并运50-150 μm的小组粒明海组粉末栓塞犬组组及组正胶双内骶 中组～模组骨组瘤手组～栓塞后脉骶48 h手组组野楚～组中少组组大出血。清2 组大小组粒明海组栓塞后组症栓塞组的组组及栓塞程度之组的组系～有待于组一步究。胶并与脉研