高催乳素血症指南
From Medscape Medical News
Endocrine Society Issues Guidelines for Management of Hyperprolactinemia
Laurie Barclay, MD
Authors and Disclosures
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February 15, 2011 — The Endocrine Society has released a new clinical practice guideline for the diagnosis and treatment of patients with hyperprolactinemia. The new recommendations for management of elevated levels of the hormone prolactin, which is associated with infertility, low sex drive, and bone loss, are reported in the February issue of the Journal of Clinical Endocrinology &
Metabolism.
The evidence-based strategies highlighted in the guidelines include assessment of the cause of hyperprolactinemia, which may include use of specific medications, renal failure, hypothyroidism, and pituitary and parasellar tumors in patients with symptomatic nonphysiologic hyperprolactinemia. Also covered are treatment of drug-induced hyperprolactinemia and of prolactinomas, and indications and adverse effects of drugs used to treat prolactinomas.
"People with high prolactin levels who have few or no symptoms and no demonstrable pituitary tumor may not need treatment, but infertile or pregnant patients, and individuals with bothersome symptoms require specialized treatment depending on the cause of their condition," said lead author Shlomo Melmed, MD, chair of the Clinical Guidelines Subcommittee of The Endocrine Society Task Force and dean at Cedars-Sinai Medical Center in Los Angeles, California, in a news release.
"This new Clinical Practice Guideline helps clinicians diagnose hyperprolactinemia, identify the most appropriate treatment and manage prolactinomas in non-pregnant and pregnant individuals." The Task Force of Endocrine Society–appointed experts, a methodologist, and a medical writer
developed the evidence-based clinical practice guideline using the Grading of Recommendations, Assessment, Development, and Evaluation system to describe the strength of recommendations as well as the quality of the underlying evidence. Consensus was established through a single group
meeting, several conference calls, and emails. Preliminary drafts of guidelines were reviewed and commented on by committees and members of The Endocrine Society, The European Society of Endocrinology, and The Pituitary Society.
Recommendations for Hyperprolactinemia
Specific recommendations for diagnosis of hyperprolactinemia include the following:
, A single measurement of serum prolactin level can confirm the diagnosis if the level is
above the upper limit of normal and the serum sample was obtained without excessive
venipuncture stress. Dynamic testing of prolactin secretion is not recommended to
diagnose hyperprolactinemia.
, Macroprolactin evaluation is recommended in patients with asymptomatic
hyperprolactinemia.
, When there is a discrepancy between a very large pituitary tumor and a mildly elevated
prolactin level, serial dilution of serum samples is recommended to eliminate the "hook
effect," or an artifact that can occur with some immunoradiometric assays leading to a
falsely low prolactin value.
Recommendations for Drug-Induced Hyperprolactinemia
Specific recommendations for management of drug-induced hyperprolactinemia are as follows:
, In a symptomatic patient with suspected medication-induced hyperprolactinemia, the drug
should be discontinued for 3 days or an alternative drug substituted, and the serum
prolactin measurement should then be repeated. However, the patient's physician should
be consulted before an antipsychotic agent is discontinued or substituted. If the drug
cannot be discontinued and the onset of the hyperprolactinemia does not coincide with
starting therapy, magnetic resonance imaging (MRI) of the pituitary gland may distinguish
medication-induced hyperprolactinemia from symptomatic hyperprolactinemia caused by a
pituitary or hypothalamic mass.
, Patients with asymptomatic medication-induced hyperprolactinemia should not be treated.
Estrogen or testosterone can be used in patients with long-term hypogonadism
(hypogonadal symptoms or low bone mass) caused by medication-induced
hyperprolactinemia.
, If it is not possible to stop the drug causing medication-induced hyperprolactinemia,
cautious administration of a dopamine agonist should be considered, in consultation with
the patient's physician.
Recommendations for Prolactinoma
Specific recommendations for management of prolactinoma are as follows:
, Dopamine agonist therapy is recommended to reduce prolactin levels and tumor size and
to restore gonadal function in patients with symptomatic prolactin-secreting
microadenomas or macroadenomas. Compared with other dopamine agonists,
cabergoline is more effective in normalizing prolactin levels and in shrinking pituitary
tumors.
, Dopamine agonists are not recommended for asymptomatic patients with
microprolactinomas. However, patients with microadenomas who have amenorrhea can
be treated with a dopamine agonist or oral contraceptives.
, In patients treated with dopamine agonists for at least 2 years who no longer have elevated
serum prolactin levels or visible tumor on MRI, careful clinical and biochemical follow-up
therapy may be tapered and perhaps discontinued.
Recommendations for Resistant, Malignant Prolactinoma
Specific recommendations for management of resistant and malignant prolactinoma are as follows: , For symptomatic patients in whom normal prolactin levels are not achieved or who have
significant shrinking of the tumor size while receiving standard doses of a dopamine
agonist, the dose should be increased rather than referring the patient for surgery. , Patients resistant to bromocriptine should be switched to cabergoline. , Symptomatic patients with prolactinomas who cannot tolerate high doses of cabergoline or
who are unresponsive to dopamine agonist therapy should be offered trans-sphenoidal
surgery. Patients intolerant of oral bromocriptine may respond to intravaginal
administration. Radiation therapy is recommended for patients in whom surgical treatment
fails or for those with aggressive or malignant prolactinomas.
, Temozolomide therapy is recommended for patients with malignant prolactinomas.
Recommendations for Pregnant Women With Prolactinoma
Specific recommendations for management of prolactinoma during pregnancy are as follows: , Women with prolactinomas should discontinue dopamine agonist therapy as soon as
pregnancy is recognized, except for selected patients with invasive macroadenomas or
adenomas abutting the optic chiasm.
, Serum prolactin measurements should not be performed during pregnancy. , Unless there is clinical evidence for tumor growth, such as visual field impairment, routine
use of pituitary MRI during pregnancy is not recommended in patients with microadenomas
or intrasellar macroadenomas.
, Women with macroprolactinomas that do not shrink during dopamine agonist therapy or
women who cannot tolerate bromocriptine or cabergoline should be counseled regarding
the potential benefits of surgical resection before attempting pregnancy. , Pregnant women with prolactinomas who experience severe headaches and/or visual field
changes should have formal visual field assessment followed by MRI without gadolinium. , Bromocriptine therapy is recommended in patients who experience symptomatic growth of
a prolactinoma during pregnancy.
The European Society of Endocrinology and The Pituitary Society cosponsored development of the
clinical practice guidelines. Members of the task force have disclosed various financial relationships
with Novartis, Ipsen, Pfizer, Novo Nordisk, Merck Serono, LG Life Sciences, and/or Teva. A
complete description is available in the original article.
J Clin Endocrinol Metab. 2011;96:273-288. Full text