体质量过大女性做中等量阻力运动对血管的好处

体质量过大女性做中等量阻力运动对血管的好处 体质量过大女性做中等量阻力运动对血管 的好处 ? 222?中华高血压杂志2007年3月第15卷第3期 ChinJHypertension,Mar2007,Vo1.15No3 轻度高血压患者应用西拉普利(cilazapril)或阿替洛 尔(atenolo1)药物治疗6月后发现:西拉普利组血 HGF水平下降,而阿替洛尔组血HGF水平无明显 改变.两研究结果不一致,故具体机制有待进一步 研究. 4参考文献 1StokerM,GherardiE,PerrymanM,eta1.Scatterfactorisa fibroblast--derivedmodulatorofepithelialcellmobility[J].Na— ture,1987,327:239-242. 2KuhlmannCR,SchaeferCA,FehseckeA,eta1.Anewsigna— llngmechanismofhepatocytegrowthfactor-inducedendothelial proliferation[J].JThrombHaemost,2005,3:2089—2095. 3ZhouVJ,WangJH,ZhangJ.Hepatocytegrowthfactorpro— tectshumanendothelialcellsagainstadvancedglycationend products—inducedapoptosis[J].BiochemBiophysResCommun, 2006,344:658—666. 4Gerasimovska—KitanovskaB,ZafirovskaK,BogdanovskaS,et a1.Decreasednitricoxideinwomenwithessentialhypertension inprehypertensivephase[J].CroatMedJ,2005,46:889—893. 5MinJK,LeeYM,KimJH,eta1.Hepatocytegrowthfactor suppressesvascularendothelialgrowthfactor—inducedexpres— sionofendothelialICAM—-1andVCAM—-1byinhibitingthenu—- clearfactor-~Bpathway[J].CircRes,2005,96:300—307. 6UrunoA,SugawaraA,KanatsukaH,eta1.Hepatocyte growthfactorstimulatesnitricoxideproductionthroughendo— thelialnitricoxidesynthaseactivationbythephosphoinositide3一 kinase/Aktpathwayandpossiblybymitogen—activatedprotein kinasekinaseinvascularendothelialcells[J].HypertensRes, 2004,27:887-895. NakanoN,MoriguchiA,MorishitaR,eta1.Roleofangioten— sin1Iintheregulationofanovelvascularmodulator,hepato— cytegrowthfactor(HGF),inexperimentalhypertensiverats [J].Hypertension,1997,30:1448—1454. 陈建英,陈晓于,黄石安,等.原发性高血压患者肝细胞生长 因子,血管紧张素?,内皮素的变化及苯那普利的干预作用I-J]. 中国循环杂志,2004,19:283—285. KomaiN,OhishiM,MorishitaR,eta1.Serumhepatocyte growthfactorconcentrationiscorrelatedwiththeforearmvaso— dilatorresponseinhypertensivepatients[J].AmJHypertens, 2002,15:499-506. OkadaM,HojoY,IkedaU,eta1.Interactionbetweenmono— cytesandvascularsmoothmusclecellsinducesexpressionof hepatocytegrowthfactor[J].JHypertens,2000,18:1825—1831. WangM,CrisostomoPR,HerringC,eta1.Humanprogenitor cellsfrombonemarroworadiposetissueproduceVEGF,HGF, andIGF-IinresponsetoTNFbyap38MAPK—-dependentmech—- anism[J].AmJPhysiolRegulIntegrCompPhysiol,2006,291: R880—884. NakamuraS,MoriguchiA,MorishitaR,eta1.Anovelvascu— larmodulator,hepatocytegrowthfactor(HGF),asapotential indexoftheseverityofhypertension[J].BiochemBiophysRes Commun,1998,242:238—243. (本文编辑:曾国琦) 体质量过大女性做中等量阻力运动对血管的好处 血管内皮功能障碍是动脉粥样硬化心血管病 (CVD)的首发机制.有氧运动能改善血管功能,减 少CVD死亡率和病残率,但阻力运动效果如何还 不是很清楚(MedSciSportSociety,2006,38:1558— 1564).该文研究目的在于检查1年阻力运动(RT) 对体质量过重,但还算健康的人的血管功能有什么 影响.3O名(15名对照组,15名RT组),指过重妇 女(BMI>25kg/m.).年龄24,44岁.在RT锻 ? 简讯? 炼1年前后用超声波检查颈动脉与肱动脉检查血管 功能,体内脂肪肌肉构成,BP,空腹血脂,血糖.结 果:RT组在1年阻力运动后,每次对抗最大阻力明 显增加(P<0.05),肌肉组织明显增加(P一0.04), 但BP,空腹血脂,血糖,胰岛素水平无变化,颈动脉 内膜一中膜厚度无变化,示血管内皮功能的血流 介导的血管扩张(FMD)峰值明显增加(P<0.05). 结论:阻力运动能改善过重妇女的肱动脉内皮功能. 789n