MQ13.103,单克隆鼠抗瓜氨酸纤维蛋白原免疫球蛋白(4.19D5克隆

Product Name Monoclonal Mouse Anti-Citrullinated Fibrinogen peptide Immunoglobulin, clone 4.19 CAT No. MQ 13.103-100 Size 100 µg Edition: February 1, 2012 Page 1 of 1 Intended use This product is for research use only. NOT for use in diagnostic or therapeutic procedures. A license from ModiQuest Research is required for use outside the research field. This product is tested for use in enzyme-linked immunosorbent assay (ELISA). Reagent provided The antibody is supplied in PBS, pH 7.2 Antibody concentration: 0.5 mg/ml Isotype Mouse IgG1 Immunogen Deiminated murine fibrinogen peptide. Specificity No tests for cross reactivity have been performed yet. Purity Protein A purified. Precautions 1. For professional users. 2. As with any product derived from biological sources, proper handling procedures should be used. 3. The product may be used in different techniques and in combination with different sample types and materials, therefore each individual laboratory should validate the applied test system. Preparation of the antibody Use antibody as supplied. Storage instructions Store at 2-8 o C. For prolonged storage add sodium azide to 0.05% Dilution guidelines ELISA: 1:(2000 x F) – 1:(4000 x F). Other applications: since applications vary, you should determine the optimum working dilution of the product that is appropriate for your specific need. For the value of the multiplication factor F, see label on vial. Unless the stability in the actual test system has been established, it is recommended to dilute the product immediately before use. Relevance Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deïminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis. Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get deiminated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis. 世联博研（北京）科技有限公司独家授权代理荷兰modiquestresearch全系列产品 单位地址：北京市丰台区角门南华12-1507，邮编：100068 全国客服热线：010-67520703，QQ：1978161627,736597338 备有大量现货，详情咨询电话010-67529703