nullCardiopulmonary ResuscitationCardiopulmonary Resuscitation
Diagnosis of cardiac and respiratory arrestDiagnosis of cardiac and respiratory arrest
Traditional methods :
1. Carotid pulse check by lay rescuers
2. Loss of consciousness
3. Pupil dilation
4. Respiratory arrest
Guideline 2000 Guideline 2000Elimination of the pulse check for lay rescuers
Evaluate for signs of circulation in 10 seconds
breathing , coughing , movement in
response to
rescue breath Assess for a pulse Assess for a pulseTime is too longer
Accurate rate 75 %
Sensibitity 90%
Specificity 60%Rate of false- positive(40%)
Rate of false- positive(40%)
Results
Pulseless Pulse
Mistakenly loss the saving opportunity
Rate of false-negative (10 %)Rate of false-negative (10 %)
Results
Pulse Pulseless
Unnecessarily do CPR Electrocardiogram changes
of Cardiac arrest Electrocardiogram changes
of Cardiac arrest Ventricular fibrillation
A flat line or only atrial wave
Pulseless Electrical Activity, PEA
The chain of Survival The chain of Survival Early access
Early CPR
Early Defibrillation
Early advanced life support
* patient with Coma ( immediately do CPR ,
not clear obstructed airways at first) Basic Life Support
--- the first ABCDBasic Life Support
--- the first ABCDAirway A
Breathing B
Circulation C
Defibrillation D Airway AirwayTilt the head backwards
Lift the jaw
Open the mouth
Clearing obstructed airways from choking
Subdiaphragmatic abdominal thrust (Heimlich maneuver) Breathing BreathingMouth to mouth or mouth to nose
Mouth to oropharyngeal tube
Mouth to shield
Mouth to mask(compressing the cricoid cartilage in order to decrease gastric distention and prevent gastric reflu)
Bag-mask ventilation challenged endotracheal intubation – resuscitation’s “gold standard”Circulation
—external chest compression Circulation
—external chest compression High-frequency(100 compressions per min)
aortic pressure ↑myocardial perfusion
pressure↑ cardiac outputs ↑ rise survival rate
Reduce interrupted compression ( compression – ventilation ratio simplified to 15:2)
Compression-only CPR: unwilling
or unable to perform mouth to
mouth or cardiogenic cardiac arrestCirculation
—Compression-only CPRCirculation
—Compression-only CPRResearch suggests:
① Survival rate with compression-only CPR in first 6~12 minutes is 40.8%
② Survival rate with chest compression add artificial ventilation is 34.1% , because artificial ventilation may be result in respiratory alkalosis. Mechanism of
external chest compression Mechanism of
external chest compression Chest pump
- sequential increased and decreased pressure
in the thoracic cavity
- valves maintaining forward direction of flow
Cardiac pump
-sequential filling and emptying of cardiac
chambers
-valves maintaining forward direction of flow Circulation CirculationThump version from 20-25 cm high to chest
Cough Version in 10-15 second
Intermittent abdominal compression-cardiopulmonary resuscitation(IAC-CPR)
Activated compression-decompression(ACD-CPR)
Phased-Chest and Abdominal ACD-CPR
(Life-stick Resuscitation)
increase mean pressure,coronary and cerebral perfusion
pressure,left ventricular and cerebral blood flowAutomated external defibrillator
--- AEDAutomated external defibrillator
--- AED① Ventricular fibrillation : may be used by 200J*3 times) or 200J、200-300J、300J
② If polymorphic ventricular tachycardia can not be clearly distinguished from ventricular fibrillation (VF), treatment would refer to be as VF
③ Atrial fibrillation :100-200J synchronized
④ Atrial flutter or supraventricular tachycardia
50- 100J synchronized
⑤ Ventricular tachycardia 100J synchronized
Biphasic waveform defibrillation
Biphasic waveform defibrillation
A compensated defibrillation for the second time in limited time
Low-energy levels(150J correspond to 200-300J)
Reduce the myocardial injury Advanced Life Support
--- the second ABCD Advanced Life Support
--- the second ABCDEndotracheal intubation (A)
Mechanical ventilation and oxygen therapy (B)
Intravenous injection (C)
electrocardiogram and blood pressure monitoring, resuscitation drug , open chest cardiac compression (C)
Differential diagnosis (D) Confirmation of
Endotracheal tube placement
Confirmation of
Endotracheal tube placement
Mark estimated depth
Breath sounds by auscultation at 5 locus
Thorax rise as inspiration
increase of SaO2
Steam in canal of artificial ventilation device
Use a specific technique or device to
prevent tube dislodgment
Mechanical ventilationMechanical ventilationLow tidal volume 6-7ml/kg(400-600ml)
Hyper ventilation High airway pressure and endogenous PEEP Intracranial hypertension;
High tidal volume Distension
Too low tidal volume hypoxia and CO2 retention
Epinephrine EN --(1) Epinephrine EN --(1)α-adrenergic receptor stimulating
Peripheral arterial vasoconstriction(not cerebral and coronary arterioles)
mean arterial pressure↑ myocardial and cerebral blood flow ↑Epinephrine EN --(2)Epinephrine EN --(2)Recommended dosage : 1.0mg(0.01-0.02mg/kg ) iv every 3-5 minutes, then 1mg + GS 250ml iv gtt, 1μg/min→3-4μg/min, or 1mg、3mg、5mg iv
Compared high dosage: 0. 1-0.2mg/kg
High dosage (>0.2mg/kg) may be harmful
Endotracheal administration:
NS 20ml + 2~2.5 time recommended dose
Intracardiac injection: only in heart operation or
chest trauma
VasopressinVasopressinAct by direct stimulation of smooth muscle V1 receptors vasoconstriction
No increased myocardial oxygen consumption
Half-life is 10 ~20 minute, longer than EN
Applicable to VF or prolonged cardiac arrest, and with PEA(pulseless electrical activity)or with asystole
Effective in patients who remain in cardiac arrest after treatment with epinephrine
Usage: 40IU iv Amiodarone(1) Amiodarone(1)Persistent VT or VF after defibrillation and epinephrine in cardiac arrest
Hemodynamically stable VT
polymorphic VT
wide-complex tachycardia
Ventricular rate control of rapid atrial arrhythmias with impaired LV function when digitalis ineffective Amiodarone(2) Amiodarone(2)Initially 300mg iv diluted in 20-30 ml in cardiac arrest
Initial dose of 150mg iv( over 10 min), followed by 1 mg/min infusion for 6 h, then 0.5mg/min
Supplementary 150mg iv repeatedly for recurrent or resistant arrhythmias or hemodynamically unstable VT
Maximum total dose: 2g/24h
adverse effects:hypotension and bradycardia Magnesium sulfate Magnesium sulfateTorsades de pointes
Arrhythmias caused by magnesium deficiency
Loading dose :1~2g /50-100ml iv (over 5-60 minutes)
Followed by an infusion of 0.5-1.0g/h
Sodium Bicarbonate(1)
Sodium Bicarbonate(1)
Only after the confirmed interventions are ineffective
Preexisting metabolic acidosis, hyperkalemia, tricyclic or phenobarbitone overdose
Protracted arrest or long resuscitative effortsSodium Bicarbonate(2)Sodium Bicarbonate(2)Acid-base balance : chest compressions
ROSC adequate alveolar ventilation
and restoration of tissue perfusion
CO2 more freely diffusible than HCO3 - into myocardial and cerebral cells intracellular acidosis
Initial dosage: 5%NaHCO3 1mEq /kg iv gtt
( 1ml≌0.6mEq ) Etiological factors
(5Hs,5Ts) Etiological factors
(5Hs,5Ts) Hypovolemia
Hypoxia
Hydrogen ion (acidosis)
Hyperkalemia
or Hypokalemia
Hyperthermia
or HypothermiaTablets (drug)
Tamponade
Tension Pneumothorax
Thrombosis coronary
Thrombosis pulmonary Optimal response
to resuscitation Optimal response
to resuscitationAwake
Responsive
Breathing spontaneously
restoration of spontaneous circulation (ROSC)
Prolong Life Support Prolong Life SupportPostresuscitation care
- Prevent and treatment SIRS and MODS
organs function support
Cerebral resuscitation
Postresuscitation syndrome Postresuscitation syndromeReperfusion failure
Reperfusion injury
Cerebral intoxication from ischemic metabolites
Coagulopathy
Postresuscitation syndrome
--- 4 phases Postresuscitation syndrome
--- 4 phases Cardiovascular dysfunction in the hours after ROSC in 24 hours
SIRS leads to MODS over 1 to 3 days
Serious infection occurs and the patient declines rapidly
Death Dopamine DopamineA potent adrenergic receptor agonist and a strong peripheral dopamine receptor agonist.
Effects are dose-dependent: 5 ~ 20μg/min/kg
Low-dose (2 ~ 4 μg/min/kg) is no longer used for acute oliguric renal failure, because
occasionally diuresis no improve renal glomerular filtration rate.
Middle dosage:5~10μg/min/kg, positive inotropic effect
High dosage:10~20 μg/min/kg, vasoconstriction
Sodium Bicarbonate Sodium Bicarbonateimmediately after ROSC
Guided by the partial pressure of CO2
Cerebral resuscitation Cerebral resuscitation Maintain relative high blood pressure during CPR
Hemodilution and mild hypothermia (32-34℃)for 12 h during CPR
thrombolysis for ameliorate hypercoagulable state
Antioxidant ,free radical scavenger
Emergency hypothermia CPB
Hyperbaric oxygen:suitable for persistent vegetative state
Ethical and legal
considerations of CPR Ethical and legal
considerations of CPRWhen withdrawal or withhold of life support?
DNAR(do not attempt resuscitation) orders
Transporting patient proceed CPR must be continue CPR
Patient is in a persistent vegetative state or terminal condition certified by 2 physicians, including 1 with special expertise in evaluation cognitive function null