睾酮可提高绝经女性的记忆力

海量下载 免费学习英语 www.englishvip.com/xinlw.htm （申请网址） Postmenopausal（绝经后的） women had better improvement in verbal learning and memory after receiving treatment with testosterone gel, compared with women who received sham（虚假的） treatment with a placebo, a new study found. Results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.   "This is the first large, placebo-controlled study of the effects of testosterone on mental skills in postmenopausal women who are not on estrogen therapy," said principal investigator Susan Davis, MBBS (MD), PhD, of Monash University, Melbourne, Australia. "Our study has confirmed our similar findings from two smaller studies in postmenopausal women and suggests that testosterone therapy may protect women against cognitive decline after menopause（更年期）."   Menopause has been linked with memory decline because of a decrease in levels of the protective hormone estrogen. Yet testosterone also is an important hormone in women because it has a role in sexual desire, bone density and energy while improving mood. In men, studies have shown that testosterone replacement has favorable effects on brain function.   In this new, investigator-initiated study, the Australian researchers randomly assigned 92 healthy postmenopausal women, ages 55 to 65, who were not receiving estrogen therapy, to receive one of two treatments for 26 weeks. The treatments were a testosterone gel (LibiGel, BioSante Pharmaceuticals) applied daily to the upper arm, or a placebo, an identical-appearing gel containing none of the medication. Neither the study participants nor the investigators were aware of which gel the women received.   Before treatment and at 12 and 26 weeks of treatment, subjects underwent comprehensive testing of their cognitive function (mental skills) using a computer-based battery of tests designed for people with normal brain function (CogState). Ninety women completed the study. The investigators found no cognitive differences between groups before the start of treatment.   After 26 weeks, the women who received testosterone therapy had a statistically significant and clinically meaningful improvement in verbal learning and memory -- how well they recalled words from a list, Davis reported. The average test score for the testosterone-treated group was 1.6 points greater than that of the placebo group. No differences between the groups were evident for any other cognitive test.   Women receiving testosterone therapy reported no major side effects related to the gel. Their testosterone levels increased with treatment but remained in the normal female range.   Although further study is needed in more women, Davis said the results are important. "There is no effective treatment to date to prevent memory decline in women, who are higher risk of dementia than men," she said.   No testosterone-only product has yet received U.S. Food and Drug Administration approval for use in women. BioSante provided the study drug and partial funding for this study but had no control over study design or data analysis. CogState Australia provided computation of the cognitive testing, which the researchers then analyzed. Davis reported receiving funding from the Australian National Health and Medical Research Council as a principal research fellow. 绝经后（绝经后的）一项新研究发现，女性在语言学习和记忆有更好的改善，妇女谁收到假（虚假的）治疗与安慰剂相比，接受治疗后，睾酮凝胶。结果星期一在内分泌学会第95届年会在旧金山。   “这是第一个大型，安慰剂对照研究的睾酮的影响谁不上的雌激素治疗绝经后妇女的心智技能，说：”首席研究员苏珊·戴维斯，MBBS（MD），博士，澳大利亚墨尔本莫纳什大学， 。“我们的研究证实了我们类似的结果从两个较小的研究在绝经后的妇女，并表明，睾丸激素疗法可能会保护妇女免遭后的认知能力下降的更年期（更年期）。“   记忆力下降，因为一个保护雌激素水平的下降已与更年期。然而，睾酮也是一个重要的女性激素，因为它有性欲，骨密度和能量的作用，同时提高情绪。在男性中，有研究表明，睾丸激素替代对脑功能具有良好的效果。   在这个新的，研究者发起的研究，澳大利亚研究人员随机分配92名健康的绝经后妇女，年龄55至65岁，谁没有接受雌激素治疗，接受两种治疗26周。治疗睾酮凝胶（LibiGel的，BioSante的制药），日常应用到上臂，或安慰剂，没有用药相同出现凝胶含有。本研究的参与者，也没有意识到凝胶妇女接受调查。   于治疗前及治疗12周和26周的受试者进行全面的测试他们的认知功能（心智技能）使用基于计算机的电池的人与正常的脑功能（CogState）的测试。90名妇女完成了研究。研究者发现没有开始治疗前两组之间的认知差异。   26周后，睾丸激素疗法的妇女谁收到有统计学显着和临床意义的改善，在语言学习和记忆 - 以及他们如何从列表中回忆的话，戴维斯。睾酮治疗组的平均测试成绩大于安慰剂组为1.6个百分点。没有群体之间的差异是显而易见的，任何其他的认知测试。   接受睾丸激素治疗的妇女凝胶有关的报道没有严重的副作用。他们的睾丸激素水平增高与治疗，但仍保持在正常的女性范围内。   虽然进一步的研究是必要的，更多的妇女戴维斯说，结果是重要的。“是迄今为止尚无有效的治疗以防止记忆力下降的妇女，谁是痴呆症的风险比男性高，”她说。   没有睾酮产品尚未得到美国食品和药物管理局批准用于妇女。BioSante的提供药物的研究，这项研究的部分资金，但没有控制权研究设计或数据分析。澳大利亚CogState提供计算的认知测试，然后，研究人员分析。戴维斯报道，接受资金从澳大利亚国家健康和医学研究理事会作为一个主要研究员。 “成千上万人疯狂下载。。。。。。 更多价值连城的绝密英语学习资料， 洛基内部秘密英语，技巧，策略 请在 网上 申请报名” 洛基国际英语 竭诚为您服务