健康足孕宝宝会分泌与母亲相异的压力激素

海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm （申请网址） A University of Calgary researcher has identified how a steroid hormone may indicate infant distress during labour and delivery. The study, published by PLOS ONE this month, suggests that a full-term, healthy baby preferentially（优先地） secretes（藏匿，分泌） a different stress hormone than its mother does. That stress hormone, corticosterone（肾上腺酮）, has not been previously studied in human development. "Fetal corticosterone, which is related to cortisol, could serve as a biomarker of fetal stress," says study lead author Katherine Wynne-Edwards, PhD, Jack Manns Professor of Comparative Endocrinology. Wynne-Edwards worked with clinical obstetrician/gynecologist Heather Edwards on the study.   "Since cortisol is found in much higher concentrations than corticosterone, it has received greater attention as an indicator of stress in both mothers and newborns."   In this study, investigators compared the concentrations of hormones in the umbilical（脐带的） cord to assess the hormones added to the circulation by the baby. Corticosterone increased during labor and delivery at a significantly greater rate compared to cortisol, although overall cortisol levels were still higher. As fetal stress increased, so did corticosterone concentrations.   Investigators analyzed umbilical cord blood samples from 265 healthy deliveries. Corticosterone concentrations varied according to the delivery -- compared to infants delivered by Caesarian section, vaginally delivered infants synthesized greater concentrations of corticosterone. When Caesarian delivery occurred because the baby's head was too large to pass through the birth canal, which was expected to be a stressor on the baby, the highest corticosterone concentrations were seen. Meanwhile, intervention to strengthen maternal contractions did not increase corticosterone concentrations.   "Newborn corticosterone synthesis might be the basis for a signal to the mother that the baby is in distress, and might also indicate that a previously unsuspected developmental transition from preferential corticosterone synthesis to preferential cortisol synthesis occurs in early life," Wynne-Edwards said. "If so, then corticosterone might be an important biomarker of adrenal function in premature infants that is not yet studied or understood."   Wynne-Edwards presented her findings at the Endocrine Society Annual Meeting in San Francisco on June 15, 2013. The study was funded by the Natural Sciences and Engineering Research Council of Canada and an Alberta Advanced Education and Technology grant, through the Faculty of Veterinary Medicine at the University of Calgary. 卡尔加里大学的一位研究员已确定了一种类固醇激素在分娩期间可能会明婴儿窘迫。这项研究发表在PLOS ONE本月初，建议足月，健康的宝宝优先（优先地）分泌（藏匿，分泌）比其母亲不同的应激激素。那应激激素，皮质酮（肾上腺酮），之前尚未在人类发展研究。“胎儿皮质酮，皮质醇，可以作为一种生物标志物的胎儿应力，说：”研究的负责人凯瑟琳·怀恩杰克·曼斯比较内分 ​​泌学教授，博士，爱德华兹。怀恩·爱德华兹曾与临床产科/妇科专家希瑟·爱德华兹的研究。   “自从发现皮质醇浓度高于皮质，它已经受到更大的关注母亲和新生儿作为一个指标的压力。”   在这项研究中，研究人员比较了激素的浓度（脐带的脐中）线，以评估流通宝宝添加激素。皮质酮增加分娩过程中一个显着更大的速率相比，皮质醇，虽然整体皮质醇水平仍较高。由于胎儿的压力增加，所以做了皮质酮浓度。   研究者分析了265名健康交付的脐带血液样本。皮质酮浓度根据不同的交付 - 交付剖腹产，阴道分娩的婴儿合成较高浓度的皮质婴儿相比。剖腹产分娩时发生的，因为宝宝的头部太大，通过出生运河，预计这对宝宝是一种应激，皮质酮浓度最高，可见一斑。同时，干预，以加强产妇宫缩没有增加皮质酮浓度。   “新生儿皮质酮合成可能是一个信号，遇险的母亲是婴儿的基础，也可能表示，以前没有料到的发展过渡从优惠皮质合成皮质醇合成优惠发生在生命早期，”怀恩爱德华兹说。然后如果是这样的话，皮质酮可能会对尚未研究或理解早产儿肾上腺皮质功能的重要的生物标志物。“   怀恩 - 爱德华兹介绍了她的研究结果于2013年6月15内分泌学会年会在旧金山。资助这项研究是由自然科学和工程研究理事会，加拿大艾伯塔省高等教育和科技补助，通过在卡尔加里大学的兽医学院。 “成千上万人疯狂下载。。。。。。 更多价值连城的绝密英语学习资料， 洛基内部秘密英语，技巧，策略 请在 网上 申请报名” 洛基国际英语 竭诚为您服务