英语科普小知识 干细胞可使软骨组织再生

海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm （申请网址） Over 20 million people in Europe suffer from osteoarthritis（骨关节炎） which can lead to extensive damage to the knee and hip cartilage（软骨）. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer. The EPSRC-funded study, published in Biomacromolecules and undertaken by University of Bristol researchers, explored the feasibility of using natural fibres such as silk and cellulose as stem cell scaffolds -- the matrix to which stem cells can cling to as they grow.   Both cellulose and silk are commonly used in textiles but the researchers demonstrated an unexpected use for the two natural polymers when mixed with stem cells. The team treated blends of silk and cellulose for use as a tiny scaffold that allows adult connective tissue stem cells to form into preliminary form of chondrocytes（软骨细胞） -- the cells that make healthy tissue cartilage -- and secrete extracellular matrix similar to natural cartilage.   Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: "We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors. This new blend can cut the cost for health providers and makes progress towards effective cell-based therapy for cartilage repair a step closer."   Dr Sameer Rahatekar, lead author from the University's Advanced Composite Centre for Innovation and Science (ACCIS), added: "We used ionic liquids for the first time to produce cellulose and silk scaffolds for stem cells differentiation. These liquids are effective in dissolving biopolymers and are environmentally benign compared to traditional solvents used for processing of cellulose and silk."   The teams are currently working on the fabrication of 3D structures from the blend suitable for implantation in patient joints with future studies focusing on understanding the peculiar interactions between the blend and stem cells towards refining the quality of regenerated cartilage. 在欧洲超过20万人患有骨关节炎（骨关节炎），这可能会导致广泛的损害膝关节和髋关节软骨（软骨）。干细胞提供了一种很有前途的，但一个关键的挑战是要一种“智能”，是软骨组织再生的生物有效。现在，研究人员已经确定了融合了自然发生的纤维如纤维素和丝绸，使负担得起的和有效的细胞为基础的治疗软骨修复更近了一步的进展情况。EPSRC资助的研究，发表在生物大分子和布里斯托尔大学的研究人员进行，探讨使用天然纤维如丝和纤维素作为干细胞支架-基质干细胞可以抱住，因为他们成长的可行性。   纤维素，丝都常用的纺织品中，但研究人员，与干细胞混合时，两种天然聚合物的一个意外的用途。该球队用于作为一个微小的支架允许成人结缔组织干细胞以形成到初步形成的软骨细胞（软骨细胞） -的细胞，使健康组织的软骨-和分泌细胞外基质类似于天然处理的丝绸和纤维素的共混物软骨。   博士瓦伊勒阿布Kafienah，从大学的细胞和分子医学学院的主要作者，说：“我们与这一发现感到惊讶，混合似乎提供复杂的化学和机械暗示，诱导干细胞分化成软骨细胞的初步形式，无需进行生化医疗服务提供者诱导使用昂贵的可溶性分化的因素，这种新的混合可以降低成本，使有效的细胞为基础的治疗软骨修复更近了一步的进展情况。“   医生萨米尔Rahatekar，从大学的高级复合中心为创新和科学（ACCIS）的主要作者，补充说：“我们首次干细胞分化产生纤维素和丝绸支架使用离子液体。这些液体是有效溶解生物聚合物和是对环境有利用于处理纤维素和丝绸的传统的溶剂。   队目前正在制作的三维结构，从混合适合植入病人关节与未来的研究重点了解特有的互动交融与对炼油干细胞再生软骨的质量。 “成千上万人疯狂下载。。。。。。 更多价值连城的绝密英语学习资料， 洛基内部秘密英语，技巧，策略 请在 网上 申请报名” 洛基国际英语 竭诚为您服务