碳酸氢钠（BP2009）

SodiumSodiumSodiumSodium BicarbonateBicarbonateBicarbonateBicarbonate General Notices (Sodium Hydrogen Carbonate, Ph Eur monograph 0195) NaHCO3 ıı84.0ıı144-55-8 ActionActionActionAction andandandand useuseuseuse Antacid; used in treatment of electrolyte deficiency. PreparationsPreparationsPreparationsPreparations Sodium Bicarbonate Ear Drops Sodium Bicarbonate Eye Lotion Sodium Bicarbonate Intravenous Infusion Sodium Bicarbonate Oral Solution Compound Sodium Bicarbonate Tablets DEFINITIONDEFINITIONDEFINITIONDEFINITION ContentContentContentContent 99.0 per cent to 101.0 per cent. CHARACTERSCHARACTERSCHARACTERSCHARACTERS AppearanceAppearanceAppearanceAppearance White or almost white, crystalline powder. SolubilitySolubilitySolubilitySolubility Soluble in water, practically insoluble in ethanol (96 per cent). When heated in the dry state or in solution, it gradually changes into sodium carbonate. IDENTIFICATIONIDENTIFICATIONIDENTIFICATIONIDENTIFICATION ıA. To 5 ml of solution S (see Tests) add 0.1 ml of phenolphthalein solution R. A pale pink colour is produced. Heat; gas is evolved and the solution becomes red. ıB. It gives the reaction of carbonates and bicarbonates (2.3.1). ıC. Solution S gives reaction (a) of sodium (2.3.1). SolutionSolutionSolutionSolution SSSS Dissolve 5.0 g in 90 ml of carbon dioxide-free water R and dilute to 100.0 ml with the same solvent. AppearanceAppearanceAppearanceAppearance ofofofof solutionsolutionsolutionsolution Solution S is clear (2.2.1) and colourless (2.2.2, Method II). CarbonatesCarbonatesCarbonatesCarbonates The pH (2.2.3) of freshly prepared solution S is not greater than 8.6. ChloridesChloridesChloridesChlorides (2.4.4)(2.4.4)(2.4.4)(2.4.4) Maximum 150 ppm. To 7 ml of solution S add 2 ml of nitric acid R and dilute to 15 ml with water R. SulphatesSulphatesSulphatesSulphates (2.4.13)(2.4.13)(2.4.13)(2.4.13) Maximum 150 ppm. To a suspension of 1.0 g in 10 ml of distilled water R add hydrochloric acid R until neutral and about 1 ml in excess. Dilute to 15 ml with distilled water R. AmmoniumAmmoniumAmmoniumAmmonium (2.4.1)(2.4.1)(2.4.1)(2.4.1) Maximum 20 ppm. Dilute 10 ml of solution S to 15 ml with water R. Prepare the standard using a mixture of 5 ml of water R and 10 ml of ammonium standard solution (1 ppm NH4) R. ArsenicArsenicArsenicArsenic (2.4.2,(2.4.2,(2.4.2,(2.4.2, MethodMethodMethodMethod AAAA)))) Maximum 2 ppm, determined on 0.5 g. CalciumCalciumCalciumCalcium (2.4.3)(2.4.3)(2.4.3)(2.4.3) Maximum 100 ppm. To a suspension of 1.0 g in 10 ml of distilled water R add hydrochloric acid R until neutral and dilute to 15 ml with distilled water R. IronIronIronIron (2.4.9)(2.4.9)(2.4.9)(2.4.9) Maximum 20 ppm. Dissolve 0.5 g in 5 ml of dilute hydrochloric acid R and dilute to 10 ml with water R. HeavyHeavyHeavyHeavy metalsmetalsmetalsmetals (2.4.8)(2.4.8)(2.4.8)(2.4.8) Maximum 10 ppm. Dissolve 2.0 g in a mixture of 2 ml of hydrochloric acid R and 18 ml of water R. 12 ml of the solution complies with test A. Prepare the reference solution using lead standard solution (1 ppm Pb) R.