2型糖尿病防治的新理念

null2型糖尿病防治的新理念2型糖尿病防治的新理念Diabetes: a disease with serious clinical outcomesDiabetes: a disease with serious clinical outcomesDiabetes is a heterogeneous metabolic disease characterized with persistent elevated blood glucose which results in increased risks of getting complicationseyes –retinopathy kidneys –nephropathy nerves –neuropathy blood vessels or arteries - heart attacks and strokes.nullType 2 Diabetes: A Complex Metabolic Disorder DyslipidaemiaImpaired insulin secretion Macrovascular complications Central obesity Insulin resistance Microvascular complications HypertensionType 2 diabetes Insulin Resistance syndromeType 2 DiabetesType 2 DiabetesInsulin resistant and low insulin secretion (54%)Insulin resistant; good insulin secretion (28.7%)Neither (1.5%)Low insulin secretion; insulin sensitive(15.9%)(n = 195)Haffner SM, et al. Circulation 2000; 101:975–980.Distribution by metabolic status among converters to type 2 diabetesMacrovascular disease in Type 2 diabetesMacrovascular disease in Type 2 diabetes 2–3 x increased risk of fatal stroke3*1. Wingard DL et al. Diabetes Care 1993; 16: 1022-25. 2. UKPDS 6. Diabetes Res 1990; 13: 1–11. 3. Balkau B et al. Lancet 1997; 350: 1680. 4. King’s Fund. Counting the Cost. BDA, 1996. 5. Most RS, Sinnock P. Diabetes Care 1983. 6: 67-91. 2–4 x increased risk of fatal heart disease3*Hypertension2 15 x increased risk of amputation4,5Cerebrovascular disease1Abnormal ECG2Intermittent claudication1*compared with general populationMicrovascular disease at diagnosis of diabetesMicrovascular disease at diagnosis of diabetes1. UKPDS 6. Diabetes Res 1990; 13: 1–11. 2. The Hypertension in Diabetes Group. J Hypertens 1993; 11: 309–17.