帕金森病痴呆的诊断与治疗指南

帕金森病痴呆的诊断与治疗指南 中华医学会神经病学分会帕金森病及运动障碍学组 中华医学会神经病学分会神经心理学与行为神经病学组 早在1877年Jean-Martin Charcot就已描述帕金森病 ( Parkinson's disease，PD)患者存在认知和性格改变，但是 直到20世纪60年代帕金森病痴呆( Parkinson's disease dementia，PDD)才引起学者们的广泛关注。据统计，PD患 者中PDD的发生率为24％-31％[1]，有70％ - 80％的PD 患者最终会发展为PDD[2]，在各种类型的痴呆中PDD占 3％～4％[1],而且PD患者以每年10％的速度进展为 PDD[3]。因而PDD已成为严重影响老年人社会功能和生活 质量的疾病。然而，目前国内临床医师对此重视不足，且相 关研究甚少，为了更好地指导临床实践以及促进国内对PDD 的相关研究，有必要制定适合于我国的PDD诊断和治 疗指南。 10. 3760/cma. j. issn. 1006-7876. 2011.09. 016 陈生弟，200025上海交通大学医学院附属瑞金医院 神经科 陈海波，100730 卫生部北 京医院神经科 万方数据 ·636· 万方数据 陈生弟 陈海波 谭玉燕 @@[ 1 ] Cummings JL. Intellectual impairment in Parkinson' s disease: clinical, pathologic, and biochemical correlates. J Geriatr Psychiatry Neurol, 1988,1:24-36. @@[2] Aarsland D, Zaccai J, Brayne C. A systematic review of prevalence studies of dementia in Parkinson' s disease. Mov Disord, 2005, 20 : 1255-1263. @@[3] de Lau LM, Schipper CM, Hofman A, et al. Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study. Arch Neurol, 2005, 62:1265-1269. @@[4] Aarsland D, Andersen K, Larsen JP, et al. Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch Neurol, 2003, 60:387-392. @@[5] Levy G, Tang MX, Cote LJ, et al. Motor impairment in PD: relationship to incident dementia and age. Neurology, 2000, 55 : 539-544. @@[6] Zetusky WJ, Jankovic J, Pirozzolo FJ. The heterogeneity of Parkinson' s disease: clinical and prognostic implications. Neurology,1985, 35:522-526. @@[7] Burn DJ, Rowan EN, Minnett T, et al. Extrapyramidal features in Parkinson' s disease with and without dementia and dementia with Lewy bodies: a cross-sectional comparative study. Mov Disord, 2003, 18:884-889. @@[8] Janvin CC, Larsen JP, Salmon DP, et al. Cognitive profiles of individual patients with Parkinson' s disease and dementia: comparison with dementia with lewy bodies and Alzheimer' s disease. Mov Disord, 2006, 21: 337-342. @@[9] Enrique N, Karen M, Karen LB, et al. Comparison of Dementia With Lewy Bodies to Alzheimer' s Disease and Parkinson' s Disease With Dementia. Mov Disord, 2004, 19:60-67. @@[10] Poewe W, Gauthier S, Aarsland D, et al. Diagnosis and management of Parkinson' s disease dementia. Int J Clin Pract, 2008, 62: 1581-1587. @@[ 11 ] Mollenhauer B, F(o)rstl H, Deusehil G, et al. Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions. Dtsch Arztebl Int, 2010, 107:684-691. @@[12] Filoteo JV, Salmon DP, Schiehser DM, et al. Verbal Learning and Memory in Patients with Dementia with Lewy Bodies or Parkinson' s Disease with Dementia. J Clin Exp Neuropsychol, 2009, 31: 823-834. @@[13] Nazem S, Siderowf AD, Duda JE, et al. Montreal cognitive assessment performance in patients with Parkinson' s disease with “ normal ” global cognition according to mini-mental state examination score. J Am Geriatr Soc, 2009, 7 : 304-308. @@[ 14] Aarsland D, Larsen JP, Lim NG, et al. Range of neuropsychiatric disturbances in patients with Parkinson' s disease. J Neurol Neurosurg Psychiatry, 1999, 67:492-496. @@[ 15 ] Aarsland D, Ballard C, Larsen JP, et al. A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson' s disease with and without dementia. Int J Geriatr Psychiatry, 2001 , 16:528-536. @@[16] Dubois B, Burn D, Goetz C, et al. Diagnostic procedures for Parkinson' s disease dementia: recommendations from the movement disorder society task force. Mov Disord, 2007, 22: 2314-2324. @@[17] Emre M, Aarsland D, Brown R, et al. Clinical diagnostic criteria for dementia associated with Parkinson' s disease. Mov Disord, 2007, 22 : 1689-1707. @@[ 18 ] Waldemar G, Dubois B, Emre M, et al. Recommendations for the diagnosis and management of Alzheimer' s disease and other disorders associated with dementia: EFNS guideline. Eur J Neurol, 2007, 14 :el-26. @@[19] Dufouil C, Clayton D, Brayne C, et al. Population norms for the MMSE in the very old: estimates based on longitudinal data. Mini Mental State Examination. Neurology, 2000, 55 : 1609 -1613. @@[20]中华医学会神经病学分会帕金森病及运动障碍学组.帕金森 病的诊断.中华神经科杂志，2006，39：408-409. @@[21]中华医学会神经病学分会帕金森病及运动障碍学组.中国帕 金森病治疗指南(第二版).中华神经科杂志，2009，42:352- 355. @@[22] Miyasaki JM, Shannon K, Voon V, et al. Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review ):report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 2006, 66:996-1002. @@[23] Eng ML, Welty TE. Management of hallucinations and psychosis in Parkinson' s disease. Am J Geriatr Pharmacother, 2010, 8: 316-330. @@[24] Horstink M, Tolosa E, Bonuccelli U, et al. Review of the therapeutic management of Parkinson' s disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part Ⅱ : late (complicated) Parkinson' s disease. Eur J Neurol, 2006, 13:1186-1202. 2011-06-04 万方数据 帕金森病痴呆的诊断与治疗指南 作者： 中华医学会神经病学分会帕金森病及运动障碍学组， 中华医学会神经病学分会神经心理学与行为神经病学组 作者单位： 刊名： 中华神经科杂志 英文刊名： Chinese Journal of Neurology 年，卷(期)： 2011,44(9) 本文链接：http://d.g.wanfangdata.com.cn/Periodical_zhsjk201109016.aspx