Cancer Cell：microRNA能够抑制癌细胞扩散

Cancer Cell：microRNA能够抑制癌细胞 扩散 2013年10月16日讯 /生物谷BIOON/--最新研究发现一组microRNA能够通过两种方式抑制病人癌 症进程。 普林斯顿大学科学家发现microRNA既能够作为治疗癌症的靶点也能够作为癌细胞转移的标志 物。相关文章发在近期的Cancer Cell杂志上。 该文章的通讯作者普林斯顿大学Yibin Kang 教授称，在70%晚期骨癌病人中发现有microRNA表 达，microRNA也作为骨癌细胞转移的标志。在骨癌转移过程中，癌细胞侵染到骨骼中并挟持破 骨细胞，这些细胞会快速的溶解骨组织，导致骨质疏松，神经压迫，产生极度的疼痛。 Kang博士称，癌细胞把破骨细胞当做劳工，而microRNA能够通过抑制破骨细胞蛋白限制破骨细 胞的数目，从而解救了破骨细胞劳工。科学家发现注射microRNA会显著降低骨癌的发展，抑制 骨骼破坏进程。Kang博士称，研究揭示microRNA能够有效治疗癌症，并能用于追踪骨癌转移。 一位科学家看过该文章并在Cancer Cell杂志的评论中写道，该研究提高了我们对microRNA在组 织特异性和病理活性中功能的认识，有助于进一步的癌症诊断，治疗和防止骨癌转移方面的研 究。（生物谷Bioon.com） Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis Brian Ell, Laura Mercatali, Toni Ibrahim, Neil Campbell, Heidi 来源： 生物谷 作者： 墨涂涂 2013-10-16 9:01:52 Schwarzenbach, Klaus Pantel, Dino Amadori, Yibin Kang Understanding the mechanism by which tumor cells influence osteoclast differentiation is crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (miRNA) expression changes in differentiating osteoclasts after exposure to tumor-conditioned media, in part through activation of NFB signaling by soluble intracellular adhesion molecule (sICAM1) secreted from bone-metastatic cancer cells. Ectopic expression of multiple miRNAs downregulated during osteoclastogenesis suppresses osteoclast differentiation by targeting important osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibits osteoclast activity and reduces osteolytic bone metastasis. Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR- 378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden. These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis. doi:10.1016/j.ccr.2013.09 PMC: PMID: