二甲双胍治疗多囊卵巢综合征克罗米酚抵抗疗效观察

二甲双胍治疗多囊卵巢综合征克罗米酚抵抗疗效观察 作者：侯灵彤，田清友，韩素新，张荣华 【关键词】 多囊卵巢综合征；二甲双胍；妊娠；不育；氯录芬；胰岛素抗药性 　　Treatment effect of metformin on clomipheneresistant patients with polycystic ovary syndrome 　　【Abstract】 AIM: To observe the treatment effect of metformin（MTF）on clomiphene (CC)resistant infertile patients with polycystic ovary syndrome (PCOS). METHODS: Among 22 CCresistant patients with POCS, 20 patients showed insulin resistance (IR). They firstly received MTF threapy for 3 months, later those who failed to conceive received MTF and CC threapy for another 3 months. At the end, the patients sexual hormone, body mass index (BMI), fasting insulin (I0), 2hour glucose to insulin ratio (G120/I120) and Homeostatic model assessmentinsulin resistance index (HOMAIR) were detected again and the results were compared with those of pretreatment. At the same time, the ovulation and pregnancy rates were calculated. RESULTS: At the end of 6month MTF treatment on 20 CCresistant patients, 12 cases (60%) resumed their ovulation, 10 cases (50%) achieved pregnancy and did not abort. In the 8 patients who did not resume ovulation, however, the level of LH, LH/FSH, BMI, I0, G120/I120 and HOMAIR decreased significantly as compared with those of pretreatment (P