阿莫西林克拉维酸钾咀嚼片（Amoxicillin and Clavulanate potassium Chewable Tablets）

阿莫西林克拉维酸钾咀嚼片（Amoxicillin and Clavulanate potassium Chewable Tablets） 阿莫西林克拉维酸钾咀嚼片(Amoxicillin and Clavulanate potassium Chewable Tablets) Amoxicillin and Clavulanate Potassium Chewable Tablets (Amoxicillin, and, Clavulanate, Tablets, Potassium, Chewable, etc) This product is a compound preparation, its components are amoxicillin and clavulanate potassium, the ratio of 2 to 1 or 4: 1. [traits] This product is a film coating, after coating, show white or light yellow. [pharmacology and toxicology] This product is a compound preparation of amoxicillin and clavulanate potassium. Amoxicillin is broad-spectrum penicillin, potassium clavulanate itself only weak antibacterial activity, but inhibitory effect of strong broad-spectrum B lactam enzyme combination, can protect against amoxicillin B lactam enzyme hydrolysis. The antibacterial spectrum of this product is the same as amoxicillin, and it has expanded. Have a good effect on the enzyme production of Staphylococcus aureus, Staphylococcus aureus, coagulase negative Staphylococcus and Enterococcus, for some B producing enzyme in intestinal bacteria, bacteria liver, Haemophilus influenzae, Moraxella Mora bacteria, Bacteroides fragilis has better antibacterial activity. This product has no effect on Enterobacteriaceae and Pseudomonas such as methicillin resistant Staphylococcus and enterobacter. [pharmacokinetics] This product is good for gastric acid stability, oral absorption, food absorption of this product has no significant impact. Fasting oral 375mg (amoxicillin, 250mg, and clavulanic acid, 125mg) and amoxicillin reached the peak concentration (Cmax) at 1.5 hours, which was about 5.6mg/L. The blood elimination half-life (t1/2b) is about 1 hours. The excretion rate of 8 hours urine was 50% ~ 78%. The pharmacokinetic parameters of clavulanic acid were the same as those for single use, and the peak blood concentration (Cmax) of 1 hours after oral administration of clavulanic acid (125g) was about 3.4mg/L in normal subjects. Protein binding rate ranged from 22% to 30%. The blood elimination half-life (t1/2b) ranged from 0.76 to 1.4 hours, and the urinary excretion rate was 46% at 8 hours. The bioavailability of oral administration was 97% and 75% respectively. [indications] This product is suitable for lower respiratory enzyme production of Haemophilus influenzae and Moraxella Mora bacteria infection, otitis media, sinusitis; enzyme production of Staphylococcus aureus and enzyme producing Enterobacteriaceae as induced by Escherichia coli, Klebsiella pneumoniae respiratory tract, urinary tract and skin soft tissue infection; can also be used for mild to moderate infection caused by enterococcus. This product can also be used for sensitive, non enzymatic infections caused by the above various infections. [usage and dosage] Take this product in your mouth and swallow it after chewing. Adult pneumonia and other moderate and severe infections: once 625 to 750mg, every 8 hours 1 times, the symptoms were basically controlled after appropriate reduction, treatment for 7~10 days. Other infections: one 375mg, 1 times every 8 hours, for 7~10 days. Children (weight = 40kg) by amoxicillin calculation, general infection: according to the weight of a 25mg/kg, every 12 hours or 1 times; according to the weight of a 20mg/kg, 1 times every 8 hours. Heavy infection: one 45mg/kg per body weight, 1 times every 12 hours, or one 40mg/kg per body weight, 1 times every 8 hours. The course of treatment is 7~10 days. Other infections were halved. Children above 40kg can be given at an adult dose. Renal function impaired creatinine clearance rate >30ml/ minutes without reduction; creatinine clearance rate of 10 ~ 30ml/ minutes every 12 hours of oral administration of the goods 250 ~ 500mg (amoxicillin to gauge) creatinine clearance rate; <10ml/ minutes every 24 hours of oral administration of the goods 250 ~ 500mg (amoxicillin in total). Hemodialysis patients were given 250 - 500mg (amoxicillin) every 24 hours according to the severity of the disease. They were taken 1 times at the end of hemodialysis and at the end of hemodialysis. [adverse effects] 1. common gastrointestinal reactions such as diarrhea, nausea and vomiting. 2. rash, especially in people with infectious mononucleosis. 3., allergic shock, drug fever and asthma can be seen. 4. occasionally increased serum aminotransferase, eosinophilia, decreased white blood cells and double infections caused by Candida or drug-resistant bacteria. [taboo] Penicillin skin test positive, and this product and other penicillin allergic drugs and infectious mononucleosis patients disable. [matters needing attention] 1. before each patient starts taking this product, he must have a penicillin skin test. 2. of cephalosporin allergy and disease history of allergic asthma, hay fever, eczema, urticaria and other severe liver dysfunction and with caution. 3. this product is cross allergic with other penicillins and cephalosporins. If an allergic reaction occurs, the product should be discontinued immediately and appropriate measures taken. 4. this product is completely cross resistant with ampicillin and cross resistance with other penicillins and cephalosporins. 5. renal dysfunction should be based on plasma creatinine clearance adjustment dose or dosing interval; hemodialysis can affect the blood concentration of amoxicillin in this product, so this product should be added 1 times during hemodialysis and at the end of. 6. for patients suspected of having syphilis accompanied by syphilis, a dark field examination should be performed before use of the product, and serum tests should be taken once a month for at least 4 months. 7. long-term or large doses of this product should be regularly checked liver, kidney, hematopoietic system function and serum potassium or sodium test. The interference of the 8. laboratory index: copper sulfate method urine test may be a false positive, but glucose test method is not affected; the serum alanine aminotransferase or aspartate aminotransferase determination value increased. [pregnant women and lactating women] 1., this product can pass placenta, umbilical cord blood concentration for maternal plasma concentration of 1/4 to 1/3, so pregnant women banned. 2., this product can be secreted into breast milk, may cause sensitization to infants and cause diarrhea, rash, infection of the coccus and so on. Therefore, lactating women should be careful to use or to stop breast-feeding during the period of medication. [children medication] [medication for elderly patients] Elderly patients should adjust the dosage or interval according to the renal function. [drug interaction] 1. aspirin, indomethacin, phenylbutazone, sulfa drugs can reduce the renal tubular excretion, the blood drug level, blood elimination half-life (t1/2b) prolonged toxicity may also increase. 2. this product is combined with allopurinol, rash incidence increased significantly, it should avoid sharing. 3., this product should not be suitable for the use of double acetaldehyde dehydrogenase inhibitors such as melphalan. 4., this product and chloramphenicol used in bacterial meningitis, the incidence of long-term sequelae is higher than the use of both. 5., this product can stimulate estrogen metabolism or reduce its intestinal and liver circulation, so it can reduce the effect of oral contraceptives. 6. chloramphenicol, erythromycin, tetracycline antibiotics and sulfa drugs such as bacteriostatic drugs can interfere with the bactericidal activity of the product, and therefore should not be used especially in the treatment of meningitis or serious infections need the sterilization drug. 7., this product can enhance the role of warfarin. 8. aminoglycoside antibiotics can increase the bactericidal effect of Enterococcus faecalis in vitro at sub mic concentration. 9. due to the absorption of this product in the gastrointestinal tract, not affected by food, it can be taken on an empty stomach or after meals, and can be served with milk and other foods. It can reduce gastrointestinal reactions with food. [drug overdose] [specifications] (1) 375mg (amoxicillin, 250mg, clavulanic acid, 125mg); (2) 625mg (amoxicillin, 500mg, clavulanic acid, 125mg); (3) 187.5mg (amoxicillin, 125mg, clavulanic acid, 62.5mg); [AMXLKLWSJJJP] The previous page, the last page, the front page