支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义【可编辑版】

支气管肺泡灌洗液中3种肿瘤标志物的含量及意义【可编辑版】 支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义 支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义 作者: 黄芳，王香玲，荫斌霞，展淑琴 【关键词】 肺肿瘤 Clinial signifiane of determination of 3 tumor markers in bronhoalveolar lavage fluid 【Abstrat】 AIM: To investigate the linial value of 3 tumor markers ,arinoembroni antigen and tissue polpeptide speifi antigen in patients ith lung aner. METHODS: The levels of CEA, CYFRA211 and TPS in serum and BALF ere measured in 62 patients ith lung aner and 36 patients ith benign lung disease b eletrohemiluminesene and ELISA respetivel. RESULTS: The levels of the 3 tumor markers measured in BALF ere muh higher in lung aner group than that in benign lung disease group and the ere higher in patients in stage III and IV than those in stage I and II. The tumor markers inreased to different degrees among the patients in various pathologial lassifiations. It as also found that the levels of these tumor markers ere higher and more sensitive in BALF than those in serum, espeiall in TPS. CONCLUSION: The measurement of the tumor markers in BALF is of more signifiant value than the measurement in serum, hih helps the earl diagnosis, pathologial lassifiation and prognosis evaluation of lung aner. 【Keords】 lung neoplasms; bronhoalveolar lavage fluid; tumor markers, biologial 【摘要】 目的: 研究支气管肺泡灌洗液(BALF)中3种肿瘤标志物癌胚抗原、组 织多肽特异性抗原(TPS)对肺癌的临床诊断意义. 方法: 采用电化学发光免疫仪法(Eles201X)、酶联免疫吸附法分别检测62例肺癌患者、36例肺部良性病变患者血清及BALF中CEA和CYFRA 21 1，TPS的含量. 结果: 肺癌患者BALF中3种肿瘤标志物的含量明显高于肺部良性病变患者，且随着TNM临床分期升高，肿瘤标志物的含量也明显升高. 在不同病理类型的肺癌中，3种肺癌肿瘤标志物升高的程度均有所不同. BALF中肿瘤标志物的含量与同期血清中的含量相比，出现更早且浓度更高，尤以TPS升高最为明显. 结论: BALF中3种肺癌标志物的检测在肺癌的早期诊断、病理类型的推断及预后判断方面都有一定的意义，其临床价值优于血清. 【关键词】 肺肿瘤;支气管肺泡灌戏段闹 姨醄支气管肺泡灌洗液中3种肿瘤标志物的含量检测及意义:.FJIa.OM 欢迎您访问范..文.家]供整理.FWjIa.Com}匆?肿瘤标记，生物学 0引言 血清肿瘤标志物在肺癌中的应用已作过大量研究，表明肺癌患者血清中癌胚抗原、细胞角蛋白片段21 1、 组织多肽特异性抗原(tissue polpeptide speifi antigen, TPS)均较肺部良性病变患者和正常对照有所升高. 但相关的临床意义，各家报道不一, 1，2,. 随着经纤维支气管肺泡灌洗术的广泛应用，纤支镜对肺癌的诊断除了常规活检、刷检外，支气管肺泡灌洗液(BALF)中肿瘤标志物的检测亦可协助临床提高对肺癌的检测率. 我们拟测定血清及BALF中CEA，CYFRA21 1，TPS，的含量，探讨其对肺癌的临床诊断价值.