基础心率论文：基础心率对步长稳心颗粒治疗早搏疗效的影响

基础心率论文：基础心率对步长稳心颗粒治疗早搏疗效的影响 基础心率论文:基础心率对步长稳心颗粒治疗早搏疗效的影响 【中文摘要】观察基础心率对步长稳心颗粒治疗早搏疗效的影响，为指导临床用药提供理论依据。方法:选择2011年3月至2011年12月山西医科大学第一医院心内科门诊就诊及住院部住院治疗的早搏患者64例，均行24小时动态心电图检查，根据24小时总心搏数分三组，组1(15例):总心搏,9万;组2(26例):总心搏9—11万;组3(23例):总心搏,11万。所有入选患者停用目前服用的其它抗心律失常药物至少5个半衰期。所有研究对象均服用步长稳心颗粒(由山东步长制药有限公司生产)，3次/日，9g/次。疗程为4周。治疗结束后再次行24小时动态心电图检查，观察治疗前后三组患者动态心电图及心悸等临床症状，比较三组疗效;并观察患者治疗前后血常规、肝肾功能、血糖、血脂、凝血系列变化及药物不良反应。结果:1.治疗前后三组平均心率比较，组3治疗后平均心率低于治疗前(P<0.05)，其余两组治疗后平均心率与同组治疗前无明显变化(P,0.05)。2(治疗前后三组早搏数比较，三组治疗后早搏数比同组治疗前均明显减少(均P,0.05);而三组早搏减少幅度差异不显著(P,0.05)。3.三组动态心电图疗效比较，三组心电图疗效显著，其中组3疗效优于组1(P<0.05)，其余两两比较均无统计学意义(P>0.05)。4.三组临床症状疗效比较，三组临床症状均明显改善，但组间两两比 较差异无统计学意义(均P >0.05)。5.治疗前后各项生化指标变化 及药物不良反应，所有入选患者治疗后血常规、肝肾功能、血糖、血 脂、凝血系列各指标与用药前无明显变化(均P>0.05);所有入选患 者用药过程中及用药后均无明显不良反应出现。结论:1.对于早搏患 者，无论基础心率快慢，稳心颗粒都有显著的心电图疗效和临床疗效， 其中，基础心率快的早搏患者心电图疗效优于基础心率缓慢者。2. 对于基础心率快的早搏患者，稳心颗粒在有效控制早搏的同时，能减 慢心率，而对缓慢心室率合并早搏的患者能有效控制早搏，但不减慢 心室率。3.对血常规、肝肾功能、血糖、血脂、凝血系列无明显影响， 无明显不良反应。 【英文摘要】: To observe the influence of basic heart rate to wenxinkeli treatment efficacyfor premature beats，to provide a theoretical basis for clinical treatment.Methods: 64 patients with premature beats from the Shanxi University affiliated firsthospital’s cardiological out-patients and in-patients departments(From March 2011 to December2011) were selected.All cases were monitored by Holter,which were divided into three groups bytotal number of heartbeats within 24 hours.Group 1(15 cases): total heartbeats,90000;group2(26 cases): total heartbeats 90000-110000; group 3 (23 cases): total heartbeats,110000.All ofthe cases stopped currently taking other anti-arrhythmic drugs at least five half-life. All the studysubjects taked Wenxinkeli(produced by Shandong Buchang Pharmaceutical Co.,Ltd.)9g eachtime,3 times a day for four weeks. After treatment, all patients were monitored by Holter again.Holter and clinical symptoms of three groups before and after treatment were respectivelyobserved,and efficacy was compared. The changes of the blood routine，liver and renal function,FPG, cholesterol,blood coagulation series before and after treatment and drug adverse drugreactions were observed.Result:1. Average heart rate after treatment in group 3 was lower than before treatment(P<0.05).There were no evident changes in the average heart rate between before and after treatment inthe other two groups(P,0.05).2. The number of premature beat after treatment in the three groups was all significantlyreduced than before treatment(P,0.05). However, the difference in the decrease amplitude ofpremature beat number in three groups was not significant(P,0.05).3. Three groups all existed remarkable Holter efficacy. Holter efficacy in group 3 was betterthan group(1P<0.05).There was no statistical significance in the remaining multiple comparison(P>0.05).4. Clinical symptoms of the three groups after treatment were all obviously improved,butthere was no statistical significance in the multiple comparison(P>0.05).5. The changes of the blood routine, liver and renal function, FPG, cholesterol,bloodcoagulation series before and after treatment were not significant(P>0.05). Adverse reactionsdid not appear in the treatment process and after treatment.Conclusion: 1.Wenxinkeli possesses remarkable Holter and clinical efficacy,whether basic heart rate ofthe patients with premature beat is fast or slow. Holter efficacy of the premature beat patientswith fast basic heart rate is better than the one with slow basic heart rate.2. To the premature beat patients with fast basic heart rate, Wenxinkeli not only effectivelycontrol premature beat,but also can slow down the heart rate.However,to the premature beatpatients with slow basic heart rate, Wenxinkeli can effectively control premature beat,and doesnot slow down the heart rate.3. Wenxinkeli does not influence the blood routine, liver and renal function, FPG,cholesterol,blood coagulation series obviously,and does not produce obvious adverse reactions. 【关键词】基础心率 稳心颗粒 早搏 疗效 【英文关键词】basic heart rate Wenxinkeli premature beat efficacy 【目录】基础心率对步长稳心颗粒治疗早搏疗效的影响 中文摘要 5-7 英文摘要 7-8 缩略词 9-10 前言 10-11 资料和方法 11-13 结果 13-14 讨论 14-16 结论 16-17 参考文献 17-19 附图 19-24 附表 24-27 综述 27-34 参考文献 31-34 个人简介 34-35 致谢 35