盐酸苯海索理化性质
性质:又名安坦。白色结晶性粉末,无臭,味微苦,微 溶于水,溶于乙醇和氯仿。由哌啶为原料制得,常用其盐酸盐。为抗震颤麻痹药,其对中枢纹状体胆碱受体有阻断作用,外周抗胆碱作用较弱,约为阿托品的(1/10),(1/3)。用于震颤麻痹(脑炎后或动脉硬化引起的震颤麻痹)对改善流涎有效,对缓解僵直,运动迟缓效较差,改善震颤明显,但总的疗效不及左旋多巴、金刚烷胺。主要用于轻症及不能耐受左旋多巴的患者。也用于药物利血平和吩噻嗪类引起的锥体外系反应以及肝豆状核变性。制剂有片剂,胶囊剂。
盐酸苯海索
结构式:
分子式:C20H32ClNO
分子量:暂无
CAS号:52-49-3
化学物质索引数据库
Title: Trihexyphenidyl Hydrochloride
CAS Registry Number: 52-49-3
CAS Name: ,-Cyclohexyl-,-phenyl-1-piperidinepropanol hydrochloride
Additional Names: 3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanol hydrochloride;
1-phenyl-1-cyclohexyl-3-piperidyl-1-propanol hydrochloride; benzhexol chloride
Trademarks: Aparkane (ICN); Artane (Wyeth); Broflex (Bioglan); Cyclodol; Pacitane (Wyeth);
Paralest (Parachemie); Pargitan (Abigo); Parkinane (Wyeth); Parkopan (Hexal); Peragit (AFI);
Pipanol (Winthrop); Sedrena (Daiichi); Tremin (Schering-Plough); Triphedinon (Toho);
Triphenidyl (Leciva); Tsiklodol
Molecular Formula: C20H32ClNO
Molecular Weight: 337.93
Percent Composition: C 71.08%, H 9.54%, Cl 10.49%, N 4.14%, O 4.73%
Literature References: Anticholinergic. Synthesis: Denton et al., J. Am. Chem. Soc. 71, 2053 (1949); Adamson, Wilkinson, US 2682543 (1954 to Burroughs Wellcome); Denton, US
2716121 (1955 to Am. Cyanamid). Resolution into isomers: Adamson, Duffin, GB 750156 (1956 to Wellcome Found.).
Properties: Crystals, dec 258.5?. Free base, mp 114.3-115.0?. Soly (g/100 ml): water at 25?,
1.0; alcohol 6; chloroform 5. More sol in methanol; very slightly sol in ether, benzene. pH of a
1% aq soln 5.5-6.0.
Melting point: Free base, mp 114.3-115.0?
Derivative Type: l-Form
Properties: Crystals from isopropyl alc, mp 264?. [,]D20 -30? (c = 0.4 in chloroform). Free
base, mp 112-113?. [,]D20 -25? (c = 0.4 in ethanol).
Melting point: mp 264?; Free base, mp 112-113?
Optical Rotation: [,]D20 -30? (c = 0.4 in chloroform); [,]D20 -25? (c = 0.4 in ethanol)
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Antimuscarinic.
Properties
State solid
Melting point 258.5 oC
Property Value Source Experimental
Properties logP 4.5 PhysProp
Property Value Source
water solubility 3.14e-03 g/l ALOGPS
logP 4.93 ALOGPS
ChemAxon logP 4.23 Molconvert
logS -5 ALOGPS
ChemAxon pKa 0 Molconvert Predicted
hydrogen acceptor ChemAxon Properties 2 count Molconvert
hydrogen donor ChemAxon 1 count Molconvert
ChemAxon polar surface area 23.47 Molconvert
rotatable bond ChemAxon 5 count Molconvert
refractivity 93.21 ChemAxon
Molconvert
polarizability 36.73
性状
本品为白色轻质结晶性粉末;无臭,味微苦,后有刺痛麻痹感。
本品在甲醇、乙醇或氯仿中溶解,在水中微溶。
熔点
本品的熔点(附录? C)为250 ,256 ?,熔融时同时分解。
盐酸苯海索 化学性质
258.5?C dec. 熔点 :
Refrigerator 储存条件 :
HO: soluble 溶解度 : 2
form : solid
color : white
Stable at RT 稳定性:
安全信息
Xn 危险品
:
22 危险类别码 :
36 安全说明 :
WGK Germany : 3
TN2625000 RTECS号: