【word】 2009年中国CHINET链球菌属细菌耐药性监测

【word】 2009年中国CHINET链球菌属细菌耐药性监测 2009年中国CHINET链球菌属细菌耐药性 监测 426?u???(???c?V???[??2010??11?i20???s10???s6?(ChinJInfectChemother?fNovtember?c2010?fV01?c10W2No?c6 2009???u??CHINET ???K?11?f ????5?f ???e9?f ??????14?f ???????? ???6?????????m???G???? ???q??1?f?K??2?f???h??2?f??????3?f????3?f?????S4?f?????????f??????5?f ??????6?f??????6?f?R???(7?f??????7?f???e8?f??????8?f?q????8?f?K?7?89?f ???]??10?f??????10?f????11?f???j?????f??????12?f?U??12?f????13?f????13?f ?d??14 ?????T?????????????e?f?W?x14?w?F??2009?????6?????U???C???R???m???GW2?????X??14?w?F??2009???U???C???? ?6????1838?RW2???a??????????(K-B??)??E???????????????????(?G?????f?????aCLSI2009???L???h??W2????1838?R ???6?????u???????6????54?c7?1(1006?t1838)?fB???w?G???6????37?c0?1(681?ti838)?f???uA????38?c9?1?fB????38?c8?1?fC ??G???R?C??????22?c3?1W2a???w?G???6????(???C???????????????????????6??W2???I?f)??8?c2?1(151?t1838)W2?@?????? ?o?????1???????6?????o?????C???R?u???n?K?e???(?R(PISP??PRSP)?????????C?O?x17?c4?1??13?c7?1W2?????m?????1 ??2??????????????(3?c8?1??1?c2?1)W2A??G??13???w?G???6???????n?K???m????????O??5?c3?1?f?????????6?????????n?K ?m????(13?c20A)???????????6??W2???????6??W4B???w?G???6??W4a???w?G???6?????????n?BW4?????n?K?m?????G?T???? 50?1?f?????G?(???(W4?h???n?KW4?P???o??W4???????(W4?????????????4?????????(?GW2???????n?K???????x???6?????(?? (?u?????????????????6???(?????V)?????n????W2???6?????????n?KW4?????n?K???m???G??????W2 ???l???T???6???5?m???G?5???????5???????????? ?u???C?????TR378?c12???l?h???4?TA?????V???T1009Kv7708(2010)06Kv0426Kv04 CHINET2009surveillanceofantibioticresistanceinStreptococcussppinChina WANGChuanqing?fW?cANGAimin?fZHANGHong?fLJWanhua?fSU NZiyong?fJJANCui?fX???fYingKv chun?fSUNHongli?fYUYunsong?fYANGQing?fHUYunjian?fAIXiaoman?fNlYuxing?fSUN Jingyong?fWANGFu?fHUFupin?fzHUDemei?fZHANGZhaoxia?fJlPing?fXUYuanhong?fSHEN Jilu?fZHU0Chao?fSUDanhong?fWEJLianhua?fWULing?fSHANBin?fDUYan?fHUANGWenxiangW2 ?c?fJABei?c(DepartmentofHospitalIn-fectionControl?fChildren 7 s HospitalofFudanUniversityW2 Shanghai201102?fChina) ???1?????T1?c?e???G???”???@???F???F???(?????C???f???????f ?J??201102?5 2?c?J?????T?G???”???@???F???5 3?c???u?????G???f???F?????”???f???F???5 4?c?u???F?????????”???9???????F???5 5?c?????G???F?????”???s???F???5 6?c???(???9???F???5 7?c?J?????T?G???F?????”???????F??l 8?c?e???G???”???????F???5 9?c?????F???G???”???s???F??I 10?c?????F???G???”???s???F???5 11?c?????F?????”???s???F???f 12?c?H???4???o?F???5 13?c?C?c?F?????”???s???F???5 14?c?????F???G???”???s???F??W2 ???1?????T???K?1(1967??)?f???f???F?????i?c?F??????W2?F?????? ???(??????W4?(???G???????????????m???G?v??W2 ?T?????1?T?q?????fE-mail?TzhuKvdm@fudan?cedu?ccnW2 Abstract?T0bjectiveToinvestigatetheresistanceofclinical isolatesofStreptococcusisolatescollectedfrom14hospitals nationwidein2009CHINETprogram?cMethodsAtotalof 1838Streptococcusisolateswerecollectedfrom14hospitals nationwideduring2009?cThesusceptibilitytestingwascarKv riedoutaccordingtoaunifiedprotocolofKirby-Bauer method(KB)andE-test?cResultswereanalyzedaccordingto CLSI2009criteria?cResultsAmongthe1838strainsof Streptococcus?fS?cpneumoniaeaccountedfor54?c7?1(1006?t 1838)?fp?chemolyticStreptococcus37?cO?1(681?t1838)?fof whichgroupAaccountedfor38?c9?1?fgroupB38?c8?1?fand groupCtoGtogetherwithotherunspecified22?c3?1?cThe isolatesofaKvhemolyticStreptococcusfromsterilebodyfluids (excludingS?cpneumoniae)accountedfor8?c2?1(15l?t 1838)?cTheprevalenceofpenicillinnon-susceptiblestrains PISPandPRSPinthenonmeningitisS?cpneumoniaeisolates fromchildrenandadolescentswere17?c4?1and13?c7?1re- spectively?fwhichwerehigherthanthatfromadults(3?c8?1 2010??11?i20???s10???s6?(ChinJInfectChemother?fNovember?c2010?fV01?c10?fNo?c6427 and1?c2?1)?cThepercentageofgroupAtoGofB-hemolyticStreptococcusstrainsresistanttopenicillinrangedfrom0to5?c3?1?c About13?c2?1ofa-hemolyticStreptococcusstrainswereresistanttopenicillin?fwhichwashigherthanotherStreptococcusisoKv lates?cMorethan50?1ofStreptococcusisolateswereresistanttoerythromycin?fclindamycin?cAllisolateswerehighlysensitivetO levofloxaein?fvancomyeinW2linezolidW2moxifloxacinandmeropenem?cConclusionsPenicillinisstillthefirstchoiceforthetreatment oftheinfectionscausedbyStreptococcusisolates(exceptCNSinfections)?cStreptococcusisolatesarestillhighlyresistantto erythromycinandclindamycininChina?c Keywords?TStreptococcus?5antibioticresistance?5antimicrobialagent?Tantimicrobialsusceptibilitytesting ?????6???????m???G?????pCHINET?????m ???G?????????u???????m???C?f????2007?????6?? ???m???G?F???C???c?f????2009?????6?????C???R ???m???G?????F???f?(?????????6?????m???G????W2 ?????c???? ??W4???? (??)????????2009??1?i1????2009??12 ?i31???f????14?w?F?????(?????????C???????? ?6?????????f??1838?RW2???????f?????????e?? ?R?f?n??????????????????W2 (--)??????????????E???????????????? ??????????????????W2?????????????x????BBL ?????V????OXOID????????W2?a?????????????6 ???m???G?????n?KE???????x?????(?????????? ??????W2 (?n)???????????????aMH?z?2??????W2 ???????6?????0?????6???a5?1?q???????wMH ?z?2??????W2?J?????[???x????OXOID?????? ????W2 ??W4???? (??)???????????aCLSI2009???????????? ????????(KKvB)?????????6?????n?KMIC?L???h ??W2?????????a?????R?x???????6??ATCC 49619W2 (??)p???w???6???w?1?C?????aOXOID?? ?6???w?1?????????[?????U???C????B???w?G???6 ???????C???f?????n???c?????[?f???-???????(?C?? ?U?????f???G?????f??ATCC25922?x?U?G?? ????W2 ?nW4?????C?? ???aWHONET5?c4?????????????0?C?? ?C??W2 ???? ??W4???6???????R?C?6 1838?R???6?????u???????6??1006?R(?? 54?c7?1)?f???u?@???????o?????1???????6?????o?? ???C???R??78?c7?1(792?R)?f?m?????1???????6?? ???o?????C???R??20?c3?1(204?R)?f???o???????? ???6???F???????????Q??W4?w??W4?L?????N?????U?? ?h?s?f????1W2???????6???o?????C???R10?R (1?c0?1)?f??????1??10???@???o?J???h?sW2 p???w?G???6????37?c0?1(681)?f?h?s?????x ???Q??W4?@??W4?L?????N??W4?(???????w?????????f?? ??1W2???uA????38?c9?1(265?t681)?fB????38?c8?1 (264?t681)?fC????10?c0?1(68?t681)?fG????4?c8?1 (33?t681)?fF????2?c30A(16?t681)?f?R?C????5?c1?1 (35?t681)?f?e?f??p???w?G???6???h?s????????2W2 0t???w?G???6??????8?c2?1(151?R)?f?h?s?????n ?w??W4?o?J???????U???????????f????1W2???u?????? ?????6???C???R???????????1???????????h?sW2 ??1???6?????a?e?f?h?s?u?C?6[?1(??)] Table1?cThesourceofStreptococcusisolates[?1(??)] 428?u???(???c?V???[??2010??11?i20???s10???s6?(ChinJInfectChemotherW2Novtember?c2010?fV01?c10?fNo?c6 ??2p???w?G???6???C?6[?1(?V)] Table2?cThesourceofB-hemolyticStreptococcusisolates[?1(?fz)] SpecimenGroupA(265)GroupB(264)GroupC(68)GroupF(16)Group G(33)ND(35) Respiratorytractsecretion85?c7(227)13?c3(35)50?c0(34)50?c0(8)60?c6(20)11?c5(4) Urine1?c5(4)48?c9(129)10?c3(7)0(0)037?c1(13) WoundW2pus3?c8(10)6?c1(16)17?c7(12)18?c8(3)15?c2(5)5?c7(2) Genitaltractsecretions3?c8(10)18?c9(50)0(0)03?c0(1)0(0) Blood1?c5(4)3?c0(8)10?c3(7)18?c8(3)3?c0(1)25?c7(9) Otherbodyfluid0?c4(1)1?c5(4)2?c9(2)0(0)6?c1(2)5?c7(2) 0thers3?c3(9)8?c3(22)8?c8(6)12?c4(2)12?c1(4)14?c3(5) ND?Tnotdone?fserogroupoftheStreptococcusisolatesisnotavailable?c ??W4???????6?????m???G?c 996?R???????6???C???????o?J???h?s?f???u ?n???n?K?????”????869?RW2?nCLSI2008???h ???fPSSPW4PISP??PRSP?C?O??73?c6?1W415?c0?1?? 11?c4?1?f???u?@???????o?????1(B?17??)710?R?f?C ???R?u3???????????C?O?x68?c9?1W417?c4?1?? 13?c7?1?f159?R?m?????1?C???R?u3???????C?O?x 95?c0?1W43?c8?1??1?c3?1?f?o?J?????????????6???? 10?R?f??1?R?xPSSP?V?f????9?R?xPRSP?f???? ?x?@???C???RW2 ???????6???????n?KW4?????n?KW4???G?(???(W4 ???????(???????g?????o???g?G???????m?????C?O?x 93?c4?1W492?c0?1W41?c0?1W40?c6?1??58?c0?1?f???h???n ?K???P???o???????(W2?e?f?????????o?????????? ?????6???C???R?????????????m???G????????3W2 ?nW48???w?G???6??W4a???w?G???6???????m???G B???w?G???6???????n?KW4???n?KW4?????n?KW4 ?U??????W4?U??????W4?U???E???????G?(???(???m?? ???C?O?x2?c0?1W468?c8?1W458?c4?1W40?c7?1W45?c4?1W4 0?c7?1??11?c4?1?f???h???n?KW4?P???o??W4????????W4 ???????(?????(W2?e?f?C????J3???w?G???6????a ???w?G???6???????m????????4W2 ??3?@??W4???o?????m?????????6?????o?????C???R???0???????????????(?????m????(?1) Table3?cResultsofsusceptibilitytestingfortheS?cpneumoniaestrainsisolat edfromadultsandchildren(?1) W2Thefiguresinthetablearethenumberofstrains?c ??4?0?????6?????0???????????????(?????m????(?1) Table4?cResultsofsusceptibilitytestingforStreptococcussOantimierob ialagents(?1) Antimicrobial agent GroupAGroupBGroupCGroupFGroupGaKvhemolytic (265)(264)(68)(16)(33)Streptococcus(151) SRSRSRSRSRSR 2010??11?i20???s10???s6?(ChinJInfectChemother?fNovember?c2010? fV01?c10?fNo?c6429 ???? ?????????d?x?f2009?????6?????C???R?????c 2007???????f???e?f???6?????????m???(???G?? ?V?f???????6??????????????16?c3?1?f?????x???Q ?????????6???C???R????W2p???w???6?????????? ?o??8?c9?1?f???uA??J3???w???6?????o??226?R?f B??8???w???6????????77?RW2?F???x?@???????? ?C???R????W2G??8???w???6?????o??20?R?fC?? ??????46?RW4F?????????c?d???VW2a???w?????6 ???????R?????o172?RB??f?J???????????????V?c ???????????????n???f?f???????K???????????M?? ????W2 ?n??CLSI2008???n?????????6?????o?????C ???R???n?K?m?????L???h???f???n?a???n?K?????? ?[???x120?hu?td???f???n?K???(???L???h???xB?2 mg?tL?f?m?????L???h???xB?8mg?tL?f???n?KMIC ?z????2??8mg?tL?x?u?????(?f????2008?????c ?????????n?K???m?????C???????????????”??W2?x ?????????f?o???C2007?????o?????h?s?C???W???? ?????6???nCLSI2009???L???h???????????f???? ?s?-?F?????????6?????o?????C???R?uPISP?? 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