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首页 > 中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极

中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极

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中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极 中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰 电极 【中文摘要】中草药是中华民族的瑰宝,是中华人民智慧的结晶。 它在许多疾病的临床治疗中发挥了极大的作用,尤其是作为一种珍贵 的天然资源,为亚洲的医疗保健事业做出了不可磨灭的贡献。中草药 巨大的商业价值和科研意义己吸引了全球的关注。随着中草药的广泛 应用,对其有效成分的快速、高灵敏度检测提出了巨大的挑战!经阅读 大量文献,发现一些药物的电化学检测报道较少,鉴于此,本文精心选 取了几种典型药物,建立了...
中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极
中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极 中草药论文:中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰 电极 【中文摘要】中草药是中华民族的瑰宝,是中华人民智慧的结晶。 它在许多疾病的临床治疗中发挥了极大的作用,尤其是作为一种珍贵 的天然资源,为亚洲的医疗保健事业做出了不可磨灭的贡献。中草药 巨大的商业价值和科研意义己吸引了全球的关注。随着中草药的广泛 应用,对其有效成分的快速、高灵敏度检测提出了巨大的挑战!经阅读 大量文献,发现一些药物的电化学检测报道较少,鉴于此,本文精心选 取了几种典型药物,建立了简单、实用、高灵敏度的电分析方法,测定 了中草药有效成分,这对于阐明药物的行为及机理,指导我国中草药 的开发和利用都具有很重要的现实意义和实用价值。本论文主要包括 以下几部分内容:1.采用循环伏安、计时电量、差示脉冲等多种电化 学手段,首次研究了丹参素钠在活化电极上的电化学行为,在pH 3.3 的Britton-Robinson缓冲溶液中,丹参素钠产生了一对受吸附控制 的准可逆的氧化 【英文摘要】Chinese herbal medicines (CHMs) have played an important role in clinical therapy for many diseases, especially as a valuable, readily available resource for healthcare in some oriental countries for thousands of years.The usage of CHMs has expanded globally and CHMs have been gaining ever-increasing interest and acceptance in many different countries. The considerable scientific significance and commercial potential of CHMs result in more and more international attention and global market demands.Electrochemical methods offer improved analytical characteristics such as short analytical time, little reagent consumption, easy operation and environmental friendly. More inadequate, the pharmacological action and reaction mechanism of medicine can be observed using these methods. So, it is very important to develop a rapid, high sensitivity method to detect the main active content in CHMs and investigate the mechanisms occurring in pharmacological actions. In this thesis, we have done some work in this field and the main results are expressed as follows:1. The voltammetric behavior of salvianic acid A sodium (SAS), was studied by cyclic voltammetry (CV), chronocoulometry, and differential pulse voltammetric (DPV)for the first time. In pH 3.3 britton-robinson (B-R) buffer solution, the medicine showed a pair of quasi-reversible redox peaks. It was found that the electrode reaction of SAS was driven by adsorption and involved two electrons and two protons transfer process. The dynamics parameters of electrode process were investigated and the reaction mechanism was proposed. Based on understanding the electrochemical process of SAS at the glassy carbon electrode (GCE), analysis of SAS can be realized. The oxidation peak currents showed linear relationship with the concentrations of SAS in the range of 5.45×10-8 to 1.09×10-5 M. The limit of detection was 5.45×10-8 M. The proposed method has high sensitivity, good precision, wide linear range, and was successfully applied to quantitative determination of the SAS in Rukuaixiao Tablets.2. In pH 7.4 phosphate buffer solution (PBS), rosmarinic acid (RA) exhibited two pairs of reversible redox peaks with surface electrode process. A value of 1.15×10-12mol/mm2 was calculated as the saturated adsorption (ΓT) of RA on the electrode surface and there were four electrons and four protons took part in the electrode reaction. Then the mechanism of electrode reaction was proposed. Under optimal conditions, the peak current showed linear dependence on the concentration of RA in the range of 3.0×10-9 to 1.0×10-6 M (r=0.9989) with a detection limit of 3.0x10-9 M. The current method was successfully applied to quantitative determination of RA in Prunella vulgaris with relatively simple extraction procedure. The recovery studied gave values from 97.90% to 105.18%.3. A highly sensitive electrochemical sensor of methotrexate has been designed. DNA molecules and Single- walled carbon nanotubes are immobilized onto a pretreated glassy carbon electrode (GCE(ox)) surface. The oxidation of methotrexate is an irreversible adsorption-controlled process on the modified electrode. The oxidation mechanism was proposed and discussed in this work. It was found that in the range of 6.0×10-8- 2.0 ×10-5 M, the currents measured by square-wave voltammetry presented a good linear property as a function of the concentrations of methotrexate. The proposed method was also successfully applied for the determination of methotrexate in human blood serum with good satisfactory. 【关键词】中草药 丹参素钠 迷迭香酸 甲氨喋呤 化学修饰电极 【英文关键词】Chinese herbal medicines salvianic acid A sodium rosmarinic acid methotrexate Chemically modified electrod 【】中草药的电化学行为及其分析应用研究 摘要 4-6 Abstract 6-7 1 绪论 10-25 1.1 中草药概 述 10 1.2 中草药活性成分分析 10-13 1.3 中草药分析 方法概述 13-16 1.4 电分析技术在中草药研究中的应用 16-20 1.5 本论文研究的目的和内容 20-21 参考文献 21-25 2 中草药丹参素钠的电化学行为及其与DNA作用研究 25-35 2.1 引言 25 2.2 实验部分 25-26 2.3 结 果与讨论 26-32 2.4 与DNA作用研究 32-33 2.5 结论 33 参考文献 33-35 3 中草药迷迭香酸的电化学行为及 其分析应用研究 35-45 3.1 引言 35 3.2 实验部分 35-36 3.3 结果与讨论 36-42 3.4 与DNA作用研究 42 3.5 结论 42 参考文献 42-45 4 甲氨喋呤在 Nafion-DNA-SWCNT修饰电极上的电化学行为及其分析应用研究 45-57 4.1 引言 45-46 4.2 实验部分 46-47 4.3 结果与讨论 47-54 4.4 结论 54 参考文献 54-57 个人简历 57-59 致谢 59 【采买全文】 1.3.9.9.38.8.4.8 1.3.8.1.13.7.2.1 同时提供论文写作一对一辅导和论文发表服务.保过包发 【说明】本文仅为中国学术文献总库合作提供,无涉版权。作者如有异议请与总库或学校联系。
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