SVHC SUPPORT DOCUMENT
Substance name: Diarsenic Trioxide
EC number: 215-481-4
CAS number: 1327-53-3
MEMBER STATE COMMITTEE
SUPPORT DOCUMENT FOR IDENTIFICATION OF
DIARSENIC TRIOXIDE
AS A SUBSTANCE OF VERY HIGH CONCERN
Adopted on 1 October 2008
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CONTENTS
JUSTIFICATION .........................................................................................................................................................3
1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES .................................3
1.1 Name and other identifiers of the substance ...................................................................................................3
1.2 Composition of the substance .........................................................................................................................3
1.3 Physico-chemical properties ...........................................................................................................................4
2 CLASSIFICATION AND LABELLING ...............................................................................................................4
2.1 Classification in Annex I of Directive 67/548/EEC........................................................................................4
REFERENCES .............................................................................................................................................................5
TABLES
Table 1: Summary of physico- chemical properties .....................................................................................................4
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Substance Name: Diarsenic Trioxide
EC Number: 215-481-4
CAS number: 1327-53-3
• The substance is identified as a CMR according to Article 57 (a) of Regulation (EC) No
1907/2006 (REACH).
Summary of the evaluation:
According to Annex I to Directive 67/548/EEC Diarsenic Trioxide is classified as a carcinogen Cat.
1 (R 45: May cause cancer).
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JUSTIFICATION
1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL
PROPERTIES
1.1 Name and other identifiers of the substance
Chemical Name: Diarsenic Trioxide
EC Name: 215-481-4
CAS Number: 1327-53-3
IUPAC Name: dioxodiarsoxane
1.2 Composition of the substance
Chemical Name: Diarsenic trioxide
EC Number: 215-481-4
CAS Number: 1327-53-3
IUPAC Name: dioxodiarsoxane
Molecular Formula: As2O3
Structural Formula:
Molecular Weight: 197.84
Typical concentration (%
w/w):
>= 99%
Concentration range (% w/w): See typical concentration
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1.3 Physico-chemical properties
Table 1: Summary of physico- chemical properties
2 CLASSIFICATION AND LABELLING
2.1 Classification in Annex I of Directive 67/548/EEC
Diarsenic trioxide has been classified according to the 19th ATP, updated in the 25th ATP, of
Directive 67/548/EEC as: Carc. Cat. 1; R45 - T+; R28 - C; R34 - N; R50-53.
It has been included in the Annex I of the Directive 67/548/EEC under index number: 033-003-00-
0.
REACH ref
Annex, §
Property IUCLID
section
Value
VII, 7.1 Physical state at 20°C and
101.3 kPa
4.1 Solid
VII, 7.2 Melting/freezing point 4.2 315°C/193°C
VII, 7.3 Boiling point 4.3 477°C
VII, 7.5 Vapour pressure 4.6 850.10-12 hPa at 20°C
VII, 7.7 Water solubility 4.8
VII, 7.8 Partition coefficient n-
octanol/water (log value)
4.7
partition
coefficient
No data available
XI, 7.16 Dissociation constant 4.21
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REFERENCES
ECB ClassLab database http://ecb.jrc.it/classification-labelling/search-classlab/
Fiche toxicologique de l’INRS FT89 : Trioxyde de diarsenic. 2006
Annex I of Directive 97/548/EEC
Commission Directive 2006/139/EC of 20 December 2006 amending Council Directive
76/769/EEC as regards restrictions on the marketing and use of arsenic compounds for the purpose
of adapting its Annexe I to technical progress, 2006.
INERIS - Fiche de données toxicologiques et environnementales des substances chimiques :
Arsenic et ses dérivés inorganiques. 2006
European Commission (2000) IUCLID Dataset, CAS 1327-53-3, 18.2.2000.