大豆异黄酮对氧化损伤血管内皮细胞的抗氧化作用

170 中国临床康复菪70巷舅7，期2006—03—20出版 饥i肥seJoⅡMf0，cfin诧越Re拗溉mlfo啊肘们^2D20D6yo正J0Ⅳo．JJ ·BASICRESEARCH· AntioxidationofsoybeanisonaVoneinVascularendothelialceUswith oxidatiVedamage★ LiuYing—hual，HuangGuo—weitChangHongILiuLitRenDa—IintXueChang—yong 1DepartmentofNut向on，GeneralHospitalofChinesePLA，Beiiing 100853，China；2LaboratoryofNutrition，InstituteofPublicHealth．Tianiin MedicalUniversitv，Tianjin300070，China uUYinq—hua★，Master，PhvsiciaIl，DepanmentofNutriti蚰，GeneralHo铲 pitalofChinesePLA，Be啪ng100853，China R盹西ved：2005一05—30Ac唧ted：2005_07-05(05一ll_4—3608／G) Abstract BACKGRoUND：Sovbeanisonavonehasavarietvofbioactivitiesandits antioxidationbecomesahotspotofresearchinrecentyears．Atpresent，the research0fsoybeanis越lavoneplacesmoreemphasisonanimalexpeTiment andclinicalobsenration．butlacksresearchDncellular1evelofhumanbodv． oBJECrrIVE：To0bservetheillfluenceofsoybeaIlisoflavoneinvascul8r endothe王iaIcellswi￡hoxidativedamage． DESlGN：ContIDlledtrialandobservation． SETrDqG：CentralLaboratow，Institute0fPublicHealth，Tian讧nMedical University． MATERk札S：TheexperimentwascompletedintheCentralLabomtory， InstituteofPublicHealth，TianjinMedica】UniversityfIDmJaIluarytoJuly 2002．Theelpe矗mentalmaterialsincludedvascularendothelialce】lstrain inhumanumbilicatvein，Iowdensitylipoprotein，soybeanisoftavoneandvj． t∞inE．efc． M凰THoDS：Thevascularendothelialcellswerecultured流秽i￡ro．Theex— perimemwasdividedinto6gmups：blankcontmlgroup，o)【idativedamage controlgmup(malondialdehydecontentwasl斗mol／L)，oxidativedaIIlage+ vitaminEcontrolgmuP(vit踟inEwas50¨mol／L)andoxidatived黝age+ soybeallisofla蚰ne】O，50，Joo“m01／Lcont叫group．neendothebdcells， whichwerejojnedwithvit砌inEandsoybeani50navoneofdifferenccon— centmtionsinadVancetobeincubatedfor24hours，wereafkctedbyoxi— dizedlowdensi‘ylipoproteinsandthenculturedcontilluallyfor24hours． AlltheindexesofantioxidationweIedeteHninedinbotllextI矗一cellaJldin． tra—cell． hIA】烈oUTCoM[Eh僵EASURES：Malondialdehydecontent，activityof superoxidedismutaseanddutathioneperoxidase，thereleaseeonditionof Iactatedehydrogenaseandpmductivequant．【yofnitrogenmonoxideinside andoutsidetheendothelialcellsofeachgroup． IUeSULTS：(量)Comparisonofmalondialdehydecontent，theactivityofsupe卜 oxidedismutaseandglutathion8per似idaseinendothelialcells0feach group：Themalondialdehydecontentwashighersignificantlyinoxidative damagecontmlgroupthaninblankcontrolgroup(P<0．01)，buttheactivity ofsuperoxidedismutaseandglutathjon。peroxidasewas10wer蝻gnj行cantly inoxidatived枷agecontrolgroupthatlinbIankcontrol舯up(P书

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